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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FMNL
Full Name:
Formin-like protein 1
Alias:
C17orf1; CLL-associated antigen KW-13; Leukocyte formin; MGC133052; MGC1894; MGC21878
Type:
Regulatory protein
Mass (Da):
121828
Number AA:
1100
UniProt ID:
O95466
International Prot ID:
IPI00025202
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0017048
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
G
N
A
A
G
S
A
E
Q
P
A
G
P
Site 2
S57
P
D
K
V
Q
L
L
S
Q
Y
D
N
E
K
K
Site 3
Y59
K
V
Q
L
L
S
Q
Y
D
N
E
K
K
W
E
Site 4
S89
A
Y
I
Q
K
L
K
S
Y
V
D
T
G
G
V
Site 5
Y90
Y
I
Q
K
L
K
S
Y
V
D
T
G
G
V
S
Site 6
T93
K
L
K
S
Y
V
D
T
G
G
V
S
R
K
V
Site 7
S106
K
V
A
A
D
W
M
S
N
L
G
F
K
R
R
Site 8
S117
F
K
R
R
V
Q
E
S
T
Q
V
L
R
E
L
Site 9
T118
K
R
R
V
Q
E
S
T
Q
V
L
R
E
L
E
Site 10
S127
V
L
R
E
L
E
T
S
L
R
T
N
H
I
G
Site 11
T162
A
F
A
Q
C
S
V
T
Y
D
M
E
S
T
D
Site 12
S173
E
S
T
D
N
G
A
S
N
S
E
K
N
K
P
Site 13
S175
T
D
N
G
A
S
N
S
E
K
N
K
P
L
E
Site 14
S184
K
N
K
P
L
E
Q
S
V
E
D
L
S
K
G
Site 15
S189
E
Q
S
V
E
D
L
S
K
G
P
P
S
S
V
Site 16
S194
D
L
S
K
G
P
P
S
S
V
P
K
S
R
H
Site 17
S195
L
S
K
G
P
P
S
S
V
P
K
S
R
H
L
Site 18
S199
P
P
S
S
V
P
K
S
R
H
L
T
I
K
L
Site 19
T203
V
P
K
S
R
H
L
T
I
K
L
T
P
A
H
Site 20
T207
R
H
L
T
I
K
L
T
P
A
H
S
R
K
A
Site 21
S211
I
K
L
T
P
A
H
S
R
K
A
L
R
N
S
Site 22
S218
S
R
K
A
L
R
N
S
R
I
V
S
Q
K
D
Site 23
S222
L
R
N
S
R
I
V
S
Q
K
D
D
V
H
V
Site 24
S260
C
V
N
E
I
A
L
S
L
N
N
K
N
P
R
Site 25
Y312
R
F
E
K
L
M
E
Y
F
R
N
E
D
S
N
Site 26
Y358
T
H
L
G
L
D
L
Y
L
E
R
L
R
L
T
Site 27
T365
Y
L
E
R
L
R
L
T
E
S
D
K
L
Q
V
Site 28
S367
E
R
L
R
L
T
E
S
D
K
L
Q
V
Q
I
Site 29
T393
A
L
L
E
D
T
E
T
K
N
A
V
L
E
H
Site 30
S434
A
E
L
E
K
Q
L
S
Q
A
R
K
E
L
E
Site 31
T442
Q
A
R
K
E
L
E
T
L
R
E
R
F
S
E
Site 32
S448
E
T
L
R
E
R
F
S
E
S
T
A
M
G
P
Site 33
S450
L
R
E
R
F
S
E
S
T
A
M
G
P
S
R
Site 34
T451
R
E
R
F
S
E
S
T
A
M
G
P
S
R
R
Site 35
S456
E
S
T
A
M
G
P
S
R
R
P
P
E
P
E
Site 36
S474
P
A
A
P
T
R
P
S
A
L
E
L
K
V
E
Site 37
S512
P
V
A
V
A
T
P
S
G
G
D
A
P
T
P
Site 38
T518
P
S
G
G
D
A
P
T
P
G
V
P
T
G
S
Site 39
T523
A
P
T
P
G
V
P
T
G
S
P
S
P
D
L
Site 40
S525
T
P
G
V
P
T
G
S
P
S
P
D
L
A
P
Site 41
S527
G
V
P
T
G
S
P
S
P
D
L
A
P
A
A
Site 42
S553
P
P
L
P
G
L
P
S
P
Q
E
A
P
P
S
Site 43
S560
S
P
Q
E
A
P
P
S
A
P
P
Q
A
P
P
Site 44
S571
Q
A
P
P
L
P
G
S
P
E
P
P
P
A
P
Site 45
T597
P
P
P
P
P
P
G
T
D
G
P
V
P
P
P
Site 46
S624
D
A
L
G
R
R
D
S
E
L
G
P
G
V
K
Site 47
T658
K
P
S
Q
I
T
G
T
V
F
T
E
L
N
D
Site 48
S675
V
L
Q
E
L
D
M
S
D
F
E
E
Q
F
K
Site 49
T683
D
F
E
E
Q
F
K
T
K
S
Q
G
P
S
L
Site 50
S685
E
E
Q
F
K
T
K
S
Q
G
P
S
L
D
L
Site 51
S689
K
T
K
S
Q
G
P
S
L
D
L
S
A
L
K
Site 52
S693
Q
G
P
S
L
D
L
S
A
L
K
S
K
A
A
Site 53
S697
L
D
L
S
A
L
K
S
K
A
A
Q
K
A
P
Site 54
T721
R
A
K
N
L
A
I
T
L
R
K
G
N
L
G
Site 55
Y760
M
R
F
L
P
T
E
Y
E
R
S
L
I
T
R
Site 56
S763
L
P
T
E
Y
E
R
S
L
I
T
R
F
E
R
Site 57
S779
Q
R
P
M
E
E
L
S
E
E
D
R
F
M
L
Site 58
T799
P
R
L
P
E
R
M
T
T
L
T
F
L
G
N
Site 59
T800
R
L
P
E
R
M
T
T
L
T
F
L
G
N
F
Site 60
T802
P
E
R
M
T
T
L
T
F
L
G
N
F
P
D
Site 61
S830
A
A
S
M
S
I
K
S
S
D
K
L
R
Q
I
Site 62
S831
A
S
M
S
I
K
S
S
D
K
L
R
Q
I
L
Site 63
Y847
I
V
L
A
F
G
N
Y
M
N
S
S
K
R
G
Site 64
S850
A
F
G
N
Y
M
N
S
S
K
R
G
A
A
Y
Site 65
Y857
S
S
K
R
G
A
A
Y
G
F
R
L
Q
S
L
Site 66
S872
D
A
L
L
E
M
K
S
T
D
R
K
Q
T
L
Site 67
T873
A
L
L
E
M
K
S
T
D
R
K
Q
T
L
L
Site 68
T878
K
S
T
D
R
K
Q
T
L
L
H
Y
L
V
K
Site 69
Y891
V
K
V
I
A
E
K
Y
P
Q
L
T
G
F
H
Site 70
S899
P
Q
L
T
G
F
H
S
D
L
H
F
L
D
K
Site 71
S911
L
D
K
A
G
S
V
S
L
D
S
V
L
A
D
Site 72
T929
L
Q
R
G
L
E
L
T
Q
R
E
F
V
R
Q
Site 73
S950
K
E
F
L
R
A
N
S
P
T
M
D
K
L
L
Site 74
T952
F
L
R
A
N
S
P
T
M
D
K
L
L
A
D
Site 75
S960
M
D
K
L
L
A
D
S
K
T
A
Q
E
A
F
Site 76
T962
K
L
L
A
D
S
K
T
A
Q
E
A
F
E
S
Site 77
S969
T
A
Q
E
A
F
E
S
V
V
E
Y
F
G
E
Site 78
Y973
A
F
E
S
V
V
E
Y
F
G
E
N
P
K
T
Site 79
T980
Y
F
G
E
N
P
K
T
T
S
P
G
L
F
F
Site 80
S982
G
E
N
P
K
T
T
S
P
G
L
F
F
S
L
Site 81
Y997
F
S
R
F
I
K
A
Y
K
K
A
E
Q
E
V
Site 82
T1020
A
Q
E
A
G
A
D
T
P
G
K
G
E
P
P
Site 83
S1031
G
E
P
P
A
P
K
S
P
P
K
A
R
R
P
Site 84
S1044
R
P
Q
M
D
L
I
S
E
L
K
R
R
Q
Q
Site 85
Y1057
Q
Q
K
E
P
L
I
Y
E
S
D
R
D
G
A
Site 86
S1059
K
E
P
L
I
Y
E
S
D
R
D
G
A
I
E
Site 87
T1078
V
I
K
T
V
P
F
T
A
R
T
G
K
R
T
Site 88
T1085
T
A
R
T
G
K
R
T
S
R
L
L
C
E
A
Site 89
S1086
A
R
T
G
K
R
T
S
R
L
L
C
E
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation