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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SGPL1
Full Name:
Sphingosine-1-phosphate lyase 1
Alias:
Sphingosine-1-phosphate aldolase
Type:
Mass (Da):
63506
Number AA:
568
UniProt ID:
O95470
International Prot ID:
IPI00099463
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005789
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0008117
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006629
GO:0006643
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
E
I
L
E
V
Y
S
T
K
A
K
N
Y
V
N
Site 2
Y29
Y
S
T
K
A
K
N
Y
V
N
G
H
C
T
K
Site 3
Y37
V
N
G
H
C
T
K
Y
E
P
W
Q
L
I
A
Site 4
S65
E
F
V
F
Q
P
E
S
L
W
S
R
F
K
K
Site 5
T95
I
Q
D
K
L
N
K
T
K
D
D
I
S
K
N
Site 6
S100
N
K
T
K
D
D
I
S
K
N
M
S
F
L
K
Site 7
S104
D
D
I
S
K
N
M
S
F
L
K
V
D
K
E
Site 8
Y112
F
L
K
V
D
K
E
Y
V
K
A
L
P
S
Q
Site 9
S118
E
Y
V
K
A
L
P
S
Q
G
L
S
S
S
A
Site 10
S122
A
L
P
S
Q
G
L
S
S
S
A
V
L
E
K
Site 11
S124
P
S
Q
G
L
S
S
S
A
V
L
E
K
L
K
Site 12
S135
E
K
L
K
E
Y
S
S
M
D
A
F
W
Q
E
Site 13
S146
F
W
Q
E
G
R
A
S
G
T
V
Y
S
G
E
Site 14
T148
Q
E
G
R
A
S
G
T
V
Y
S
G
E
E
K
Site 15
S151
R
A
S
G
T
V
Y
S
G
E
E
K
L
T
E
Site 16
T157
Y
S
G
E
E
K
L
T
E
L
L
V
K
A
Y
Site 17
T232
A
F
E
K
G
I
K
T
P
E
I
V
A
P
Q
Site 18
S240
P
E
I
V
A
P
Q
S
A
H
A
A
F
N
K
Site 19
S277
R
A
M
R
R
A
I
S
R
N
T
A
M
L
V
Site 20
T280
R
R
A
I
S
R
N
T
A
M
L
V
C
S
T
Site 21
Y331
V
F
M
E
K
A
G
Y
P
L
E
H
P
F
D
Site 22
S346
F
R
V
K
G
V
T
S
I
S
A
D
T
H
K
Site 23
Y356
A
D
T
H
K
Y
G
Y
A
P
K
G
S
S
L
Site 24
S361
Y
G
Y
A
P
K
G
S
S
L
V
L
Y
S
D
Site 25
S362
G
Y
A
P
K
G
S
S
L
V
L
Y
S
D
K
Site 26
Y366
K
G
S
S
L
V
L
Y
S
D
K
K
Y
R
N
Site 27
S367
G
S
S
L
V
L
Y
S
D
K
K
Y
R
N
Y
Site 28
Y371
V
L
Y
S
D
K
K
Y
R
N
Y
Q
F
F
V
Site 29
Y374
S
D
K
K
Y
R
N
Y
Q
F
F
V
D
T
D
Site 30
Y387
T
D
W
Q
G
G
I
Y
A
S
P
T
I
A
G
Site 31
S389
W
Q
G
G
I
Y
A
S
P
T
I
A
G
S
R
Site 32
T391
G
G
I
Y
A
S
P
T
I
A
G
S
R
P
G
Site 33
S395
A
S
P
T
I
A
G
S
R
P
G
G
I
S
A
Site 34
Y416
M
H
F
G
E
N
G
Y
V
E
A
T
K
Q
I
Site 35
T426
A
T
K
Q
I
I
K
T
A
R
F
L
K
S
E
Site 36
S449
V
F
G
N
P
Q
L
S
V
I
A
L
G
S
R
Site 37
S455
L
S
V
I
A
L
G
S
R
D
F
D
I
Y
R
Site 38
Y461
G
S
R
D
F
D
I
Y
R
L
S
N
L
M
T
Site 39
S464
D
F
D
I
Y
R
L
S
N
L
M
T
A
K
G
Site 40
T468
Y
R
L
S
N
L
M
T
A
K
G
W
N
L
N
Site 41
S507
F
L
K
D
I
R
E
S
V
T
Q
I
M
K
N
Site 42
T509
K
D
I
R
E
S
V
T
Q
I
M
K
N
P
K
Site 43
Y550
S
V
F
L
D
S
L
Y
S
T
D
T
V
T
Q
Site 44
T552
F
L
D
S
L
Y
S
T
D
T
V
T
Q
G
S
Site 45
T554
D
S
L
Y
S
T
D
T
V
T
Q
G
S
Q
M
Site 46
T556
L
Y
S
T
D
T
V
T
Q
G
S
Q
M
N
G
Site 47
S559
T
D
T
V
T
Q
G
S
Q
M
N
G
S
P
K
Site 48
S564
Q
G
S
Q
M
N
G
S
P
K
P
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation