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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCA1
Full Name:
ATP-binding cassette sub-family A member 1
Alias:
ABC1; ABC-1; ATP-binding cassette 1; ATP-binding cassette transporter 1; ATP-binding cassette, sub-family A (ABC1) member 1; CERP; Cholesterol efflux regulatory protein; HDLDT1; Tangier disease; TGD
Type:
Transport protein, ABC
Mass (Da):
254286
Number AA:
2261
UniProt ID:
O95477
International Prot ID:
IPI00293460
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
GO:0045121
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0008509
PhosphoSite+
KinaseNET
Biological Process:
GO:0032488
GO:0007186
GO:0033344
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
L
L
W
K
N
L
T
F
R
R
R
Q
T
C
Site 2
T22
L
T
F
R
R
R
Q
T
C
Q
L
L
L
E
V
Site 3
S45
I
L
I
S
V
R
L
S
Y
P
P
Y
E
Q
H
Site 4
Y46
L
I
S
V
R
L
S
Y
P
P
Y
E
Q
H
E
Site 5
Y49
V
R
L
S
Y
P
P
Y
E
Q
H
E
C
H
F
Site 6
S63
F
P
N
K
A
M
P
S
A
G
T
L
P
W
V
Site 7
Y84
A
N
N
P
C
F
R
Y
P
T
P
G
E
A
P
Site 8
T86
N
P
C
F
R
Y
P
T
P
G
E
A
P
G
V
Site 9
Y115
D
A
R
R
L
L
L
Y
S
Q
K
D
T
S
M
Site 10
S116
A
R
R
L
L
L
Y
S
Q
K
D
T
S
M
K
Site 11
T120
L
L
Y
S
Q
K
D
T
S
M
K
D
M
R
K
Site 12
T131
D
M
R
K
V
L
R
T
L
Q
Q
I
K
K
S
Site 13
S138
T
L
Q
Q
I
K
K
S
S
S
N
L
K
L
Q
Site 14
T153
D
F
L
V
D
N
E
T
F
S
G
F
L
Y
H
Site 15
Y159
E
T
F
S
G
F
L
Y
H
N
L
S
L
P
K
Site 16
S163
G
F
L
Y
H
N
L
S
L
P
K
S
T
V
D
Site 17
S167
H
N
L
S
L
P
K
S
T
V
D
K
M
L
R
Site 18
T192
Q
G
Y
Q
L
H
L
T
S
L
C
N
G
S
K
Site 19
S193
G
Y
Q
L
H
L
T
S
L
C
N
G
S
K
S
Site 20
S200
S
L
C
N
G
S
K
S
E
E
M
I
Q
L
G
Site 21
S245
P
I
L
R
T
L
N
S
T
S
P
F
P
S
K
Site 22
T246
I
L
R
T
L
N
S
T
S
P
F
P
S
K
E
Site 23
S247
L
R
T
L
N
S
T
S
P
F
P
S
K
E
L
Site 24
S251
N
S
T
S
P
F
P
S
K
E
L
A
E
A
T
Site 25
S274
T
L
A
Q
E
L
F
S
M
R
S
W
S
D
M
Site 26
S277
Q
E
L
F
S
M
R
S
W
S
D
M
R
Q
E
Site 27
T289
R
Q
E
V
M
F
L
T
N
V
N
S
S
S
S
Site 28
S293
M
F
L
T
N
V
N
S
S
S
S
S
T
Q
I
Site 29
S294
F
L
T
N
V
N
S
S
S
S
S
T
Q
I
Y
Site 30
S295
L
T
N
V
N
S
S
S
S
S
T
Q
I
Y
Q
Site 31
S297
N
V
N
S
S
S
S
S
T
Q
I
Y
Q
A
V
Site 32
T298
V
N
S
S
S
S
S
T
Q
I
Y
Q
A
V
S
Site 33
Y301
S
S
S
S
T
Q
I
Y
Q
A
V
S
R
I
V
Site 34
S321
G
G
G
L
K
I
K
S
L
N
W
Y
E
D
N
Site 35
Y325
K
I
K
S
L
N
W
Y
E
D
N
N
Y
K
A
Site 36
Y330
N
W
Y
E
D
N
N
Y
K
A
L
F
G
G
N
Site 37
T345
G
T
E
E
D
A
E
T
F
Y
D
N
S
T
T
Site 38
Y347
E
E
D
A
E
T
F
Y
D
N
S
T
T
P
Y
Site 39
Y354
Y
D
N
S
T
T
P
Y
C
N
D
L
M
K
N
Site 40
S364
D
L
M
K
N
L
E
S
S
P
L
S
R
I
I
Site 41
S365
L
M
K
N
L
E
S
S
P
L
S
R
I
I
W
Site 42
S368
N
L
E
S
S
P
L
S
R
I
I
W
K
A
L
Site 43
T386
L
V
G
K
I
L
Y
T
P
D
T
P
A
T
R
Site 44
T389
K
I
L
Y
T
P
D
T
P
A
T
R
Q
V
M
Site 45
T425
E
L
S
P
K
I
W
T
F
M
E
N
S
Q
E
Site 46
S476
K
H
P
E
D
V
Q
S
S
N
G
S
V
Y
T
Site 47
S480
D
V
Q
S
S
N
G
S
V
Y
T
W
R
E
A
Site 48
Y482
Q
S
S
N
G
S
V
Y
T
W
R
E
A
F
N
Site 49
T483
S
S
N
G
S
V
Y
T
W
R
E
A
F
N
E
Site 50
T515
N
K
L
E
P
I
A
T
E
V
W
L
I
N
K
Site 51
S523
E
V
W
L
I
N
K
S
M
E
L
L
D
E
R
Site 52
Y554
E
L
P
H
H
V
K
Y
K
I
R
M
D
I
D
Site 53
Y573
T
N
K
I
K
D
G
Y
W
D
P
G
P
R
A
Site 54
Y588
D
P
F
E
D
M
R
Y
V
W
G
G
F
A
Y
Site 55
T609
Q
A
I
I
R
V
L
T
G
T
E
K
K
T
G
Site 56
Y618
T
E
K
K
T
G
V
Y
M
Q
Q
M
P
Y
P
Site 57
Y627
Q
Q
M
P
Y
P
C
Y
V
D
D
I
F
L
R
Site 58
T670
K
E
A
R
L
K
E
T
M
R
I
M
G
L
D
Site 59
S812
Q
W
D
N
L
F
E
S
P
V
E
E
D
G
F
Site 60
T822
E
E
D
G
F
N
L
T
T
S
V
S
M
M
L
Site 61
Y850
E
A
V
F
P
G
Q
Y
G
I
P
R
P
W
Y
Site 62
Y857
Y
G
I
P
R
P
W
Y
F
P
C
T
K
S
Y
Site 63
Y864
Y
F
P
C
T
K
S
Y
W
F
G
E
E
S
D
Site 64
S870
S
Y
W
F
G
E
E
S
D
E
K
S
H
P
G
Site 65
S874
G
E
E
S
D
E
K
S
H
P
G
S
N
Q
K
Site 66
S878
D
E
K
S
H
P
G
S
N
Q
K
R
I
S
E
Site 67
S884
G
S
N
Q
K
R
I
S
E
I
C
M
E
E
E
Site 68
T893
I
C
M
E
E
E
P
T
H
L
K
L
G
V
S
Site 69
T940
G
H
N
G
A
G
K
T
T
T
M
S
I
L
T
Site 70
Y958
P
P
T
S
G
T
A
Y
I
L
G
K
D
I
R
Site 71
S966
I
L
G
K
D
I
R
S
E
M
S
T
I
R
Q
Site 72
T970
D
I
R
S
E
M
S
T
I
R
Q
N
L
G
V
Site 73
Y997
V
E
E
H
I
W
F
Y
A
R
L
K
G
L
S
Site 74
S1004
Y
A
R
L
K
G
L
S
E
K
H
V
K
A
E
Site 75
S1023
A
L
D
V
G
L
P
S
S
K
L
K
S
K
T
Site 76
S1024
L
D
V
G
L
P
S
S
K
L
K
S
K
T
S
Site 77
S1028
L
P
S
S
K
L
K
S
K
T
S
Q
L
S
G
Site 78
T1030
S
S
K
L
K
S
K
T
S
Q
L
S
G
G
M
Site 79
S1031
S
K
L
K
S
K
T
S
Q
L
S
G
G
M
Q
Site 80
S1042
G
G
M
Q
R
K
L
S
V
A
L
A
F
V
G
Site 81
Y1066
P
T
A
G
V
D
P
Y
S
R
R
G
I
W
E
Site 82
S1067
T
A
G
V
D
P
Y
S
R
R
G
I
W
E
L
Site 83
T1083
L
K
Y
R
Q
G
R
T
I
I
L
S
T
H
H
Site 84
S1087
Q
G
R
T
I
I
L
S
T
H
H
M
D
E
A
Site 85
Y1127
N
Q
L
G
T
G
Y
Y
L
T
L
V
K
K
D
Site 86
T1129
L
G
T
G
Y
Y
L
T
L
V
K
K
D
V
E
Site 87
S1137
L
V
K
K
D
V
E
S
S
L
S
S
C
R
N
Site 88
S1138
V
K
K
D
V
E
S
S
L
S
S
C
R
N
S
Site 89
S1140
K
D
V
E
S
S
L
S
S
C
R
N
S
S
S
Site 90
S1141
D
V
E
S
S
L
S
S
C
R
N
S
S
S
T
Site 91
S1145
S
L
S
S
C
R
N
S
S
S
T
V
S
Y
L
Site 92
S1146
L
S
S
C
R
N
S
S
S
T
V
S
Y
L
K
Site 93
S1147
S
S
C
R
N
S
S
S
T
V
S
Y
L
K
K
Site 94
T1148
S
C
R
N
S
S
S
T
V
S
Y
L
K
K
E
Site 95
S1150
R
N
S
S
S
T
V
S
Y
L
K
K
E
D
S
Site 96
Y1151
N
S
S
S
T
V
S
Y
L
K
K
E
D
S
V
Site 97
S1157
S
Y
L
K
K
E
D
S
V
S
Q
S
S
S
D
Site 98
S1159
L
K
K
E
D
S
V
S
Q
S
S
S
D
A
G
Site 99
S1161
K
E
D
S
V
S
Q
S
S
S
D
A
G
L
G
Site 100
S1163
D
S
V
S
Q
S
S
S
D
A
G
L
G
S
D
Site 101
S1169
S
S
D
A
G
L
G
S
D
H
E
S
D
T
L
Site 102
S1173
G
L
G
S
D
H
E
S
D
T
L
T
I
D
V
Site 103
T1175
G
S
D
H
E
S
D
T
L
T
I
D
V
S
A
Site 104
T1177
D
H
E
S
D
T
L
T
I
D
V
S
A
I
S
Site 105
S1192
N
L
I
R
K
H
V
S
E
A
R
L
V
E
D
Site 106
Y1206
D
I
G
H
E
L
T
Y
V
L
P
Y
E
A
A
Site 107
S1230
H
E
I
D
D
R
L
S
D
L
G
I
S
S
Y
Site 108
S1236
L
S
D
L
G
I
S
S
Y
G
I
S
E
T
T
Site 109
Y1237
S
D
L
G
I
S
S
Y
G
I
S
E
T
T
L
Site 110
S1240
G
I
S
S
Y
G
I
S
E
T
T
L
E
E
I
Site 111
T1242
S
S
Y
G
I
S
E
T
T
L
E
E
I
F
L
Site 112
T1243
S
Y
G
I
S
E
T
T
L
E
E
I
F
L
K
Site 113
S1255
F
L
K
V
A
E
E
S
G
V
D
A
E
T
S
Site 114
T1261
E
S
G
V
D
A
E
T
S
D
G
T
L
P
A
Site 115
S1262
S
G
V
D
A
E
T
S
D
G
T
L
P
A
R
Site 116
T1265
D
A
E
T
S
D
G
T
L
P
A
R
R
N
R
Site 117
S1280
R
A
F
G
D
K
Q
S
C
L
R
P
F
T
E
Site 118
T1286
Q
S
C
L
R
P
F
T
E
D
D
A
A
D
P
Site 119
S1296
D
A
A
D
P
N
D
S
D
I
D
P
E
S
R
Site 120
S1302
D
S
D
I
D
P
E
S
R
E
T
D
L
L
S
Site 121
T1305
I
D
P
E
S
R
E
T
D
L
L
S
G
M
D
Site 122
S1309
S
R
E
T
D
L
L
S
G
M
D
G
K
G
S
Site 123
S1316
S
G
M
D
G
K
G
S
Y
Q
V
K
G
W
K
Site 124
Y1317
G
M
D
G
K
G
S
Y
Q
V
K
G
W
K
L
Site 125
S1343
R
L
L
I
A
R
R
S
R
K
G
F
F
A
Q
Site 126
Y1374
I
V
P
P
F
G
K
Y
P
S
L
E
L
Q
P
Site 127
S1376
P
P
F
G
K
Y
P
S
L
E
L
Q
P
W
M
Site 128
Y1384
L
E
L
Q
P
W
M
Y
N
E
Q
Y
T
F
V
Site 129
Y1388
P
W
M
Y
N
E
Q
Y
T
F
V
S
N
D
A
Site 130
T1399
S
N
D
A
P
E
D
T
G
T
L
E
L
L
N
Site 131
T1401
D
A
P
E
D
T
G
T
L
E
L
L
N
A
L
Site 132
T1427
E
G
N
P
I
P
D
T
P
C
Q
A
G
E
E
Site 133
T1437
Q
A
G
E
E
E
W
T
T
A
P
V
P
Q
T
Site 134
T1438
A
G
E
E
E
W
T
T
A
P
V
P
Q
T
I
Site 135
S1466
P
S
P
A
C
Q
C
S
S
D
K
I
K
K
M
Site 136
T1501
A
D
I
L
Q
D
L
T
G
R
N
I
S
D
Y
Site 137
S1506
D
L
T
G
R
N
I
S
D
Y
L
V
K
T
Y
Site 138
Y1508
T
G
R
N
I
S
D
Y
L
V
K
T
Y
V
Q
Site 139
S1536
E
F
R
Y
G
G
F
S
L
G
V
S
N
T
Q
Site 140
S1540
G
G
F
S
L
G
V
S
N
T
Q
A
L
P
P
Site 141
T1542
F
S
L
G
V
S
N
T
Q
A
L
P
P
S
Q
Site 142
S1548
N
T
Q
A
L
P
P
S
Q
E
V
N
D
A
T
Site 143
T1555
S
Q
E
V
N
D
A
T
K
Q
M
K
K
H
L
Site 144
S1569
L
K
L
A
K
D
S
S
A
D
R
F
L
N
S
Site 145
S1576
S
A
D
R
F
L
N
S
L
G
R
F
M
T
G
Site 146
T1582
N
S
L
G
R
F
M
T
G
L
D
T
R
N
N
Site 147
S1625
L
Q
K
G
E
N
P
S
H
Y
G
I
T
A
F
Site 148
Y1627
K
G
E
N
P
S
H
Y
G
I
T
A
F
N
H
Site 149
S1644
N
L
T
K
Q
Q
L
S
E
V
A
P
M
T
T
Site 150
S1682
F
L
I
Q
E
R
V
S
K
A
K
H
L
Q
F
Site 151
Y1729
I
C
F
Q
Q
K
S
Y
V
S
S
T
N
L
P
Site 152
S1732
Q
Q
K
S
Y
V
S
S
T
N
L
P
V
L
A
Site 153
S1842
F
G
E
N
R
F
V
S
P
L
S
W
D
L
V
Site 154
S1845
N
R
F
V
S
P
L
S
W
D
L
V
G
R
N
Site 155
S1886
R
P
V
N
A
K
L
S
P
L
N
D
E
D
E
Site 156
S1953
G
V
N
G
A
G
K
S
S
T
F
K
M
L
T
Site 157
T1955
N
G
A
G
K
S
S
T
F
K
M
L
T
G
D
Site 158
T1960
S
S
T
F
K
M
L
T
G
D
T
T
V
T
R
Site 159
T1964
K
M
L
T
G
D
T
T
V
T
R
G
D
A
F
Site 160
Y2037
R
K
L
G
L
V
K
Y
G
E
K
Y
A
G
N
Site 161
Y2041
L
V
K
Y
G
E
K
Y
A
G
N
Y
S
G
G
Site 162
S2054
G
G
N
K
R
K
L
S
T
A
M
A
L
I
G
Site 163
S2096
S
V
V
K
E
G
R
S
V
V
L
T
S
H
S
Site 164
T2100
E
G
R
S
V
V
L
T
S
H
S
M
E
E
C
Site 165
S2101
G
R
S
V
V
L
T
S
H
S
M
E
E
C
E
Site 166
S2127
G
R
F
R
C
L
G
S
V
Q
H
L
K
N
R
Site 167
Y2139
K
N
R
F
G
D
G
Y
T
I
V
V
R
I
A
Site 168
S2166
F
G
L
A
F
P
G
S
V
P
K
E
K
H
R
Site 169
Y2178
K
H
R
N
M
L
Q
Y
Q
L
P
S
S
L
S
Site 170
S2182
M
L
Q
Y
Q
L
P
S
S
L
S
S
L
A
R
Site 171
S2192
S
S
L
A
R
I
F
S
I
L
S
Q
S
K
K
Site 172
S2195
A
R
I
F
S
I
L
S
Q
S
K
K
R
L
H
Site 173
S2197
I
F
S
I
L
S
Q
S
K
K
R
L
H
I
E
Site 174
Y2206
K
R
L
H
I
E
D
Y
S
V
S
Q
T
T
L
Site 175
S2207
R
L
H
I
E
D
Y
S
V
S
Q
T
T
L
D
Site 176
S2209
H
I
E
D
Y
S
V
S
Q
T
T
L
D
Q
V
Site 177
T2211
E
D
Y
S
V
S
Q
T
T
L
D
Q
V
F
V
Site 178
S2225
V
N
F
A
K
D
Q
S
D
D
D
H
L
K
D
Site 179
S2234
D
D
H
L
K
D
L
S
L
H
K
N
Q
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation