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Updated November 2019
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Protein Info
Short Name:
SEC24B
Full Name:
Protein transport protein Sec24B
Alias:
MGC48822; SC24B; SEC24; SEC24 family, member B; SEC24-related protein B
Type:
Vesicle protein
Mass (Da):
137418
Number AA:
1268
UniProt ID:
O95487
International Prot ID:
IPI00030851
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030127
GO:0005789
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005215
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006888
GO:0006886
GO:0016044
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
A
P
A
G
S
S
H
P
A
A
S
A
R
Site 2
S13
G
S
S
H
P
A
A
S
A
R
I
P
P
K
F
Site 3
S55
Q
N
Q
M
Q
V
P
S
G
Y
G
L
H
H
Q
Site 4
Y64
Y
G
L
H
H
Q
N
Y
I
A
P
S
G
H
Y
Site 5
S68
H
Q
N
Y
I
A
P
S
G
H
Y
S
Q
G
P
Site 6
Y71
Y
I
A
P
S
G
H
Y
S
Q
G
P
G
K
M
Site 7
S72
I
A
P
S
G
H
Y
S
Q
G
P
G
K
M
T
Site 8
S80
Q
G
P
G
K
M
T
S
L
P
L
D
T
Q
C
Site 9
T85
M
T
S
L
P
L
D
T
Q
C
G
D
Y
Y
S
Site 10
Y90
L
D
T
Q
C
G
D
Y
Y
S
A
L
Y
T
V
Site 11
Y91
D
T
Q
C
G
D
Y
Y
S
A
L
Y
T
V
P
Site 12
Y95
G
D
Y
Y
S
A
L
Y
T
V
P
T
Q
N
V
Site 13
T96
D
Y
Y
S
A
L
Y
T
V
P
T
Q
N
V
T
Site 14
T99
S
A
L
Y
T
V
P
T
Q
N
V
T
P
N
T
Site 15
T103
T
V
P
T
Q
N
V
T
P
N
T
V
N
Q
Q
Site 16
T106
T
Q
N
V
T
P
N
T
V
N
Q
Q
P
G
A
Site 17
Y117
Q
P
G
A
Q
Q
L
Y
S
R
G
P
P
A
P
Site 18
S118
P
G
A
Q
Q
L
Y
S
R
G
P
P
A
P
H
Site 19
S139
G
S
F
Q
G
A
A
S
S
A
S
H
L
H
T
Site 20
S140
S
F
Q
G
A
A
S
S
A
S
H
L
H
T
S
Site 21
S142
Q
G
A
A
S
S
A
S
H
L
H
T
S
A
S
Site 22
T146
S
S
A
S
H
L
H
T
S
A
S
Q
P
Y
S
Site 23
S147
S
A
S
H
L
H
T
S
A
S
Q
P
Y
S
S
Site 24
S149
S
H
L
H
T
S
A
S
Q
P
Y
S
S
F
V
Site 25
S153
T
S
A
S
Q
P
Y
S
S
F
V
N
H
Y
N
Site 26
S154
S
A
S
Q
P
Y
S
S
F
V
N
H
Y
N
S
Site 27
Y159
Y
S
S
F
V
N
H
Y
N
S
P
A
M
Y
S
Site 28
S161
S
F
V
N
H
Y
N
S
P
A
M
Y
S
A
S
Site 29
Y165
H
Y
N
S
P
A
M
Y
S
A
S
S
S
V
A
Site 30
S166
Y
N
S
P
A
M
Y
S
A
S
S
S
V
A
S
Site 31
S168
S
P
A
M
Y
S
A
S
S
S
V
A
S
Q
G
Site 32
S169
P
A
M
Y
S
A
S
S
S
V
A
S
Q
G
F
Site 33
S170
A
M
Y
S
A
S
S
S
V
A
S
Q
G
F
P
Site 34
S173
S
A
S
S
S
V
A
S
Q
G
F
P
S
T
C
Site 35
T179
A
S
Q
G
F
P
S
T
C
G
H
Y
A
M
S
Site 36
T187
C
G
H
Y
A
M
S
T
V
S
N
A
A
Y
P
Site 37
S189
H
Y
A
M
S
T
V
S
N
A
A
Y
P
S
V
Site 38
Y193
S
T
V
S
N
A
A
Y
P
S
V
S
Y
P
S
Site 39
S195
V
S
N
A
A
Y
P
S
V
S
Y
P
S
L
P
Site 40
S197
N
A
A
Y
P
S
V
S
Y
P
S
L
P
A
G
Site 41
Y198
A
A
Y
P
S
V
S
Y
P
S
L
P
A
G
D
Site 42
S200
Y
P
S
V
S
Y
P
S
L
P
A
G
D
T
Y
Site 43
T206
P
S
L
P
A
G
D
T
Y
G
Q
M
F
T
S
Site 44
Y207
S
L
P
A
G
D
T
Y
G
Q
M
F
T
S
Q
Site 45
S213
T
Y
G
Q
M
F
T
S
Q
N
A
P
T
V
R
Site 46
T218
F
T
S
Q
N
A
P
T
V
R
P
V
K
D
N
Site 47
S226
V
R
P
V
K
D
N
S
F
S
G
Q
N
T
A
Site 48
T232
N
S
F
S
G
Q
N
T
A
I
S
H
P
S
P
Site 49
S235
S
G
Q
N
T
A
I
S
H
P
S
P
L
P
P
Site 50
S238
N
T
A
I
S
H
P
S
P
L
P
P
L
P
S
Site 51
S245
S
P
L
P
P
L
P
S
Q
Q
H
H
Q
Q
Q
Site 52
S253
Q
Q
H
H
Q
Q
Q
S
L
S
G
Y
S
T
L
Site 53
S255
H
H
Q
Q
Q
S
L
S
G
Y
S
T
L
T
W
Site 54
Y257
Q
Q
Q
S
L
S
G
Y
S
T
L
T
W
S
S
Site 55
T259
Q
S
L
S
G
Y
S
T
L
T
W
S
S
P
G
Site 56
T261
L
S
G
Y
S
T
L
T
W
S
S
P
G
L
P
Site 57
S263
G
Y
S
T
L
T
W
S
S
P
G
L
P
S
T
Site 58
S264
Y
S
T
L
T
W
S
S
P
G
L
P
S
T
Q
Site 59
S269
W
S
S
P
G
L
P
S
T
Q
D
N
L
I
R
Site 60
T270
S
S
P
G
L
P
S
T
Q
D
N
L
I
R
N
Site 61
T279
D
N
L
I
R
N
H
T
G
S
L
A
V
A
N
Site 62
S281
L
I
R
N
H
T
G
S
L
A
V
A
N
N
N
Site 63
T292
A
N
N
N
P
T
I
T
V
A
D
S
L
S
C
Site 64
S310
Q
N
V
Q
P
P
K
S
S
P
V
V
S
T
V
Site 65
S311
N
V
Q
P
P
K
S
S
P
V
V
S
T
V
L
Site 66
S315
P
K
S
S
P
V
V
S
T
V
L
S
G
S
S
Site 67
T316
K
S
S
P
V
V
S
T
V
L
S
G
S
S
G
Site 68
S321
V
S
T
V
L
S
G
S
S
G
S
S
S
T
R
Site 69
S322
S
T
V
L
S
G
S
S
G
S
S
S
T
R
T
Site 70
S325
L
S
G
S
S
G
S
S
S
T
R
T
P
P
T
Site 71
S326
S
G
S
S
G
S
S
S
T
R
T
P
P
T
A
Site 72
T329
S
G
S
S
S
T
R
T
P
P
T
A
N
H
P
Site 73
T332
S
S
T
R
T
P
P
T
A
N
H
P
V
E
P
Site 74
T341
N
H
P
V
E
P
V
T
S
V
T
Q
P
S
E
Site 75
S342
H
P
V
E
P
V
T
S
V
T
Q
P
S
E
L
Site 76
Y360
K
G
V
Q
Y
G
E
Y
V
N
N
Q
A
S
S
Site 77
S366
E
Y
V
N
N
Q
A
S
S
A
P
T
P
L
S
Site 78
S367
Y
V
N
N
Q
A
S
S
A
P
T
P
L
S
S
Site 79
T370
N
Q
A
S
S
A
P
T
P
L
S
S
T
S
D
Site 80
S373
S
S
A
P
T
P
L
S
S
T
S
D
D
E
E
Site 81
S374
S
A
P
T
P
L
S
S
T
S
D
D
E
E
E
Site 82
S392
D
E
E
A
G
V
D
S
S
S
T
T
S
S
A
Site 83
S393
E
E
A
G
V
D
S
S
S
T
T
S
S
A
S
Site 84
S394
E
A
G
V
D
S
S
S
T
T
S
S
A
S
P
Site 85
T395
A
G
V
D
S
S
S
T
T
S
S
A
S
P
M
Site 86
T396
G
V
D
S
S
S
T
T
S
S
A
S
P
M
P
Site 87
S397
V
D
S
S
S
T
T
S
S
A
S
P
M
P
N
Site 88
S398
D
S
S
S
T
T
S
S
A
S
P
M
P
N
S
Site 89
S400
S
S
T
T
S
S
A
S
P
M
P
N
S
Y
D
Site 90
S405
S
A
S
P
M
P
N
S
Y
D
A
L
E
G
G
Site 91
Y406
A
S
P
M
P
N
S
Y
D
A
L
E
G
G
S
Site 92
S413
Y
D
A
L
E
G
G
S
Y
P
D
M
L
S
S
Site 93
Y414
D
A
L
E
G
G
S
Y
P
D
M
L
S
S
S
Site 94
S419
G
S
Y
P
D
M
L
S
S
S
A
S
S
P
A
Site 95
S420
S
Y
P
D
M
L
S
S
S
A
S
S
P
A
P
Site 96
S421
Y
P
D
M
L
S
S
S
A
S
S
P
A
P
D
Site 97
S423
D
M
L
S
S
S
A
S
S
P
A
P
D
P
A
Site 98
S424
M
L
S
S
S
A
S
S
P
A
P
D
P
A
P
Site 99
S437
A
P
E
P
D
P
A
S
A
P
A
P
A
S
A
Site 100
S453
A
P
V
V
P
Q
P
S
K
M
A
K
P
F
G
Site 101
Y461
K
M
A
K
P
F
G
Y
G
Y
P
T
L
Q
P
Site 102
Y463
A
K
P
F
G
Y
G
Y
P
T
L
Q
P
G
Y
Site 103
T465
P
F
G
Y
G
Y
P
T
L
Q
P
G
Y
Q
N
Site 104
S479
N
A
T
A
P
L
I
S
G
V
Q
P
S
N
P
Site 105
Y488
V
Q
P
S
N
P
V
Y
S
G
F
Q
Q
Y
P
Site 106
Y494
V
Y
S
G
F
Q
Q
Y
P
Q
Q
Y
P
G
V
Site 107
Y498
F
Q
Q
Y
P
Q
Q
Y
P
G
V
N
Q
L
S
Site 108
S505
Y
P
G
V
N
Q
L
S
S
S
I
G
G
L
S
Site 109
S512
S
S
S
I
G
G
L
S
L
Q
S
S
P
Q
P
Site 110
S516
G
G
L
S
L
Q
S
S
P
Q
P
E
S
L
R
Site 111
S521
Q
S
S
P
Q
P
E
S
L
R
P
V
N
L
T
Site 112
T528
S
L
R
P
V
N
L
T
Q
E
R
N
I
L
P
Site 113
T537
E
R
N
I
L
P
M
T
P
V
W
A
P
V
P
Site 114
S556
D
L
K
K
L
N
C
S
P
D
S
F
R
C
T
Site 115
S559
K
L
N
C
S
P
D
S
F
R
C
T
L
T
N
Site 116
T563
S
P
D
S
F
R
C
T
L
T
N
I
P
Q
T
Site 117
T565
D
S
F
R
C
T
L
T
N
I
P
Q
T
Q
A
Site 118
Y611
R
C
R
S
C
R
T
Y
I
N
P
F
V
S
F
Site 119
Y641
D
V
P
E
E
F
M
Y
N
P
L
T
R
S
Y
Site 120
T645
E
F
M
Y
N
P
L
T
R
S
Y
G
E
P
H
Site 121
Y648
Y
N
P
L
T
R
S
Y
G
E
P
H
K
R
P
Site 122
S660
K
R
P
E
V
Q
N
S
T
V
E
F
I
A
S
Site 123
S667
S
T
V
E
F
I
A
S
S
D
Y
M
L
R
P
Site 124
S668
T
V
E
F
I
A
S
S
D
Y
M
L
R
P
P
Site 125
Y670
E
F
I
A
S
S
D
Y
M
L
R
P
P
Q
P
Site 126
T716
K
L
P
G
D
S
R
T
R
I
G
F
M
T
F
Site 127
T722
R
T
R
I
G
F
M
T
F
D
S
T
I
H
F
Site 128
Y730
F
D
S
T
I
H
F
Y
N
L
Q
E
G
L
S
Site 129
S737
Y
N
L
Q
E
G
L
S
Q
P
Q
M
L
I
V
Site 130
Y763
D
S
L
L
V
N
L
Y
E
S
K
E
L
I
K
Site 131
T781
N
A
L
P
N
M
F
T
N
T
R
E
T
H
S
Site 132
T786
M
F
T
N
T
R
E
T
H
S
A
L
G
P
A
Site 133
S802
Q
A
A
F
K
L
M
S
P
T
G
G
R
V
S
Site 134
T804
A
F
K
L
M
S
P
T
G
G
R
V
S
V
F
Site 135
S809
S
P
T
G
G
R
V
S
V
F
Q
T
Q
L
P
Site 136
S817
V
F
Q
T
Q
L
P
S
L
G
A
G
L
L
Q
Site 137
S825
L
G
A
G
L
L
Q
S
R
E
D
P
N
Q
R
Site 138
S834
E
D
P
N
Q
R
S
S
T
K
V
V
Q
H
L
Site 139
T835
D
P
N
Q
R
S
S
T
K
V
V
Q
H
L
G
Site 140
S856
K
K
L
A
L
D
C
S
G
Q
Q
T
A
V
D
Site 141
S876
S
Q
Y
S
D
L
A
S
L
A
C
M
S
K
Y
Site 142
Y883
S
L
A
C
M
S
K
Y
S
A
G
C
I
Y
Y
Site 143
Y889
K
Y
S
A
G
C
I
Y
Y
Y
P
S
F
H
Y
Site 144
Y890
Y
S
A
G
C
I
Y
Y
Y
P
S
F
H
Y
T
Site 145
S901
F
H
Y
T
H
N
P
S
Q
A
E
K
L
Q
K
Site 146
Y913
L
Q
K
D
L
K
R
Y
L
T
R
K
I
G
F
Site 147
T915
K
D
L
K
R
Y
L
T
R
K
I
G
F
E
A
Site 148
S950
V
R
S
T
D
L
L
S
L
A
N
I
N
P
D
Site 149
S974
E
E
S
L
T
D
T
S
L
V
C
F
Q
T
A
Site 150
Y984
C
F
Q
T
A
L
L
Y
T
S
S
K
G
E
R
Site 151
S987
T
A
L
L
Y
T
S
S
K
G
E
R
R
I
R
Site 152
S1030
A
N
M
A
V
D
R
S
V
S
S
S
L
S
D
Site 153
S1032
M
A
V
D
R
S
V
S
S
S
L
S
D
A
R
Site 154
S1034
V
D
R
S
V
S
S
S
L
S
D
A
R
D
A
Site 155
S1036
R
S
V
S
S
S
L
S
D
A
R
D
A
L
V
Site 156
S1055
D
S
L
S
A
Y
G
S
T
V
S
N
L
Q
H
Site 157
T1056
S
L
S
A
Y
G
S
T
V
S
N
L
Q
H
S
Site 158
S1058
S
A
Y
G
S
T
V
S
N
L
Q
H
S
A
L
Site 159
S1063
T
V
S
N
L
Q
H
S
A
L
M
A
P
S
S
Site 160
T1091
Q
K
A
F
R
T
G
T
S
T
R
L
D
D
R
Site 161
S1092
K
A
F
R
T
G
T
S
T
R
L
D
D
R
V
Site 162
T1093
A
F
R
T
G
T
S
T
R
L
D
D
R
V
Y
Site 163
Y1100
T
R
L
D
D
R
V
Y
A
M
C
Q
I
K
S
Site 164
Y1122
K
M
I
H
P
N
L
Y
R
I
D
R
L
T
D
Site 165
T1128
L
Y
R
I
D
R
L
T
D
E
G
A
V
H
V
Site 166
S1149
Q
P
P
L
Q
K
L
S
A
E
K
L
T
R
E
Site 167
T1197
A
S
I
P
Q
K
M
T
H
L
P
E
L
D
T
Site 168
T1204
T
H
L
P
E
L
D
T
L
S
S
E
R
A
R
Site 169
S1206
L
P
E
L
D
T
L
S
S
E
R
A
R
S
F
Site 170
S1207
P
E
L
D
T
L
S
S
E
R
A
R
S
F
I
Site 171
S1212
L
S
S
E
R
A
R
S
F
I
T
W
L
R
D
Site 172
S1224
L
R
D
S
R
P
L
S
P
I
L
H
I
V
K
Site 173
S1234
L
H
I
V
K
D
E
S
P
A
K
A
E
F
F
Site 174
T1249
Q
H
L
I
E
D
R
T
E
A
A
F
S
Y
Y
Site 175
S1254
D
R
T
E
A
A
F
S
Y
Y
E
F
L
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation