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Updated November 2019
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Protein Info
Short Name:
LPHN2
Full Name:
Latrophilin-2
Alias:
Calcium-independent alpha-latrotoxin receptor 2; KIAA0786; Latrophilin 2; Latrophilin homolog 1; LEC1; Lectomedin-1; LPHH1
Type:
Receptor, G protein-coupled
Mass (Da):
163349
Number AA:
1459
UniProt ID:
O95490
International Prot ID:
IPI00410232
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0016524
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
G
L
V
R
R
E
L
S
C
E
G
Y
S
I
D
Site 2
Y45
R
E
L
S
C
E
G
Y
S
I
D
L
R
C
P
Site 3
Y64
I
M
I
E
S
A
N
Y
G
R
T
D
D
K
I
Site 4
Y85
Q
M
E
N
T
D
C
Y
L
P
D
A
F
K
I
Site 5
Y122
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
E
C
Site 6
Y150
I
V
D
S
P
C
I
Y
E
A
E
Q
K
A
G
Site 7
Y171
L
Q
A
A
D
K
I
Y
F
M
P
W
T
P
Y
Site 8
T182
W
T
P
Y
R
T
D
T
L
I
E
Y
A
S
L
Site 9
Y186
R
T
D
T
L
I
E
Y
A
S
L
E
D
F
Q
Site 10
S188
D
T
L
I
E
Y
A
S
L
E
D
F
Q
N
S
Site 11
T198
D
F
Q
N
S
R
Q
T
T
T
Y
K
L
P
N
Site 12
T199
F
Q
N
S
R
Q
T
T
T
Y
K
L
P
N
R
Site 13
Y201
N
S
R
Q
T
T
T
Y
K
L
P
N
R
V
D
Site 14
T210
L
P
N
R
V
D
G
T
G
F
V
V
Y
D
G
Site 15
T236
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
Site 16
S240
D
L
R
T
R
I
K
S
G
E
A
I
I
N
Y
Site 17
Y247
S
G
E
A
I
I
N
Y
A
N
Y
H
D
T
S
Site 18
Y250
A
I
I
N
Y
A
N
Y
H
D
T
S
P
Y
R
Site 19
T262
P
Y
R
W
G
G
K
T
D
I
D
L
A
V
D
Site 20
Y294
V
I
S
Q
L
N
P
Y
T
L
R
F
E
A
T
Site 21
T295
I
S
Q
L
N
P
Y
T
L
R
F
E
A
T
W
Site 22
T304
R
F
E
A
T
W
E
T
V
Y
D
K
R
A
A
Site 23
Y306
E
A
T
W
E
T
V
Y
D
K
R
A
A
S
N
Site 24
S326
G
V
L
Y
V
V
R
S
V
Y
Q
D
N
E
S
Site 25
Y328
L
Y
V
V
R
S
V
Y
Q
D
N
E
S
E
T
Site 26
S333
S
V
Y
Q
D
N
E
S
E
T
G
K
N
S
I
Site 27
Y342
T
G
K
N
S
I
D
Y
I
Y
N
T
R
L
N
Site 28
Y344
K
N
S
I
D
Y
I
Y
N
T
R
L
N
R
G
Site 29
T346
S
I
D
Y
I
Y
N
T
R
L
N
R
G
E
Y
Site 30
Y353
T
R
L
N
R
G
E
Y
V
D
V
P
F
P
N
Site 31
Y364
P
F
P
N
Q
Y
Q
Y
I
A
A
V
D
Y
N
Site 32
Y370
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
Q
L
Site 33
S389
N
N
F
I
L
R
Y
S
L
E
F
G
P
P
D
Site 34
T403
D
P
A
Q
V
P
T
T
A
V
T
I
T
S
S
Site 35
S419
E
L
F
K
T
I
I
S
T
T
S
T
T
S
Q
Site 36
S422
K
T
I
I
S
T
T
S
T
T
S
Q
K
G
P
Site 37
T423
T
I
I
S
T
T
S
T
T
S
Q
K
G
P
M
Site 38
S425
I
S
T
T
S
T
T
S
Q
K
G
P
M
S
T
Site 39
S431
T
S
Q
K
G
P
M
S
T
T
V
A
G
S
Q
Site 40
T432
S
Q
K
G
P
M
S
T
T
V
A
G
S
Q
E
Site 41
T433
Q
K
G
P
M
S
T
T
V
A
G
S
Q
E
G
Site 42
S437
M
S
T
T
V
A
G
S
Q
E
G
S
K
G
T
Site 43
S441
V
A
G
S
Q
E
G
S
K
G
T
K
P
P
P
Site 44
S451
T
K
P
P
P
A
V
S
T
T
K
I
P
P
I
Site 45
S501
K
G
T
R
G
T
A
S
Y
L
C
M
I
S
T
Site 46
T510
L
C
M
I
S
T
G
T
W
N
P
K
G
P
D
Site 47
S541
R
S
G
E
N
A
A
S
L
A
N
E
L
A
K
Site 48
S583
Q
L
Q
E
L
K
P
S
E
K
D
S
A
G
R
Site 49
S587
L
K
P
S
E
K
D
S
A
G
R
S
Y
N
K
Site 50
S591
E
K
D
S
A
G
R
S
Y
N
K
L
Q
K
R
Site 51
Y592
K
D
S
A
G
R
S
Y
N
K
L
Q
K
R
E
Site 52
T601
K
L
Q
K
R
E
K
T
C
R
A
Y
L
K
A
Site 53
Y605
R
E
K
T
C
R
A
Y
L
K
A
I
V
D
T
Site 54
S624
L
R
P
E
A
L
E
S
W
K
H
M
N
S
S
Site 55
T636
N
S
S
E
Q
A
H
T
A
T
M
L
L
D
T
Site 56
S696
G
I
K
G
A
G
S
S
I
Q
L
S
A
N
T
Site 57
S700
A
G
S
S
I
Q
L
S
A
N
T
V
K
Q
N
Site 58
T703
S
I
Q
L
S
A
N
T
V
K
Q
N
S
R
N
Site 59
S728
R
S
L
G
Q
F
L
S
T
E
N
A
T
I
K
Site 60
S745
A
D
F
I
G
R
N
S
T
I
A
V
N
S
H
Site 61
T746
D
F
I
G
R
N
S
T
I
A
V
N
S
H
V
Site 62
S755
A
V
N
S
H
V
I
S
V
S
I
N
K
E
S
Site 63
S757
N
S
H
V
I
S
V
S
I
N
K
E
S
S
R
Site 64
S762
S
V
S
I
N
K
E
S
S
R
V
Y
L
T
D
Site 65
Y766
N
K
E
S
S
R
V
Y
L
T
D
P
V
L
F
Site 66
Y783
P
H
I
D
P
D
N
Y
F
N
A
N
C
S
F
Site 67
T797
F
W
N
Y
S
E
R
T
M
M
G
Y
W
S
T
Site 68
Y801
S
E
R
T
M
M
G
Y
W
S
T
Q
G
C
K
Site 69
S803
R
T
M
M
G
Y
W
S
T
Q
G
C
K
L
V
Site 70
T804
T
M
M
G
Y
W
S
T
Q
G
C
K
L
V
D
Site 71
T812
Q
G
C
K
L
V
D
T
N
K
T
R
T
T
C
Site 72
T817
V
D
T
N
K
T
R
T
T
C
A
C
S
H
L
Site 73
T818
D
T
N
K
T
R
T
T
C
A
C
S
H
L
T
Site 74
T881
G
L
Q
S
D
R
N
T
I
H
K
N
L
C
I
Site 75
S945
M
L
V
E
V
F
E
S
E
Y
S
R
K
K
Y
Site 76
Y947
V
E
V
F
E
S
E
Y
S
R
K
K
Y
Y
Y
Site 77
Y952
S
E
Y
S
R
K
K
Y
Y
Y
V
A
G
Y
L
Site 78
Y953
E
Y
S
R
K
K
Y
Y
Y
V
A
G
Y
L
F
Site 79
Y954
Y
S
R
K
K
Y
Y
Y
V
A
G
Y
L
F
P
Site 80
Y973
G
V
S
A
A
I
D
Y
K
S
Y
G
T
E
K
Site 81
S975
S
A
A
I
D
Y
K
S
Y
G
T
E
K
A
C
Site 82
T1022
K
M
V
K
H
S
N
T
L
K
P
D
S
S
R
Site 83
S1027
S
N
T
L
K
P
D
S
S
R
L
E
N
I
K
Site 84
Y1095
Q
K
K
V
R
K
E
Y
G
K
C
F
R
H
S
Site 85
Y1103
G
K
C
F
R
H
S
Y
C
C
G
G
L
P
T
Site 86
T1110
Y
C
C
G
G
L
P
T
E
S
P
H
S
S
V
Site 87
S1112
C
G
G
L
P
T
E
S
P
H
S
S
V
K
A
Site 88
S1115
L
P
T
E
S
P
H
S
S
V
K
A
S
T
T
Site 89
S1116
P
T
E
S
P
H
S
S
V
K
A
S
T
T
R
Site 90
S1120
P
H
S
S
V
K
A
S
T
T
R
T
S
A
R
Site 91
T1121
H
S
S
V
K
A
S
T
T
R
T
S
A
R
Y
Site 92
T1124
V
K
A
S
T
T
R
T
S
A
R
Y
S
S
G
Site 93
S1125
K
A
S
T
T
R
T
S
A
R
Y
S
S
G
T
Site 94
Y1128
T
T
R
T
S
A
R
Y
S
S
G
T
Q
S
R
Site 95
S1129
T
R
T
S
A
R
Y
S
S
G
T
Q
S
R
I
Site 96
S1130
R
T
S
A
R
Y
S
S
G
T
Q
S
R
I
R
Site 97
T1132
S
A
R
Y
S
S
G
T
Q
S
R
I
R
R
M
Site 98
S1134
R
Y
S
S
G
T
Q
S
R
I
R
R
M
W
N
Site 99
T1143
I
R
R
M
W
N
D
T
V
R
K
Q
S
E
S
Site 100
S1148
N
D
T
V
R
K
Q
S
E
S
S
F
I
S
G
Site 101
S1150
T
V
R
K
Q
S
E
S
S
F
I
S
G
D
I
Site 102
S1151
V
R
K
Q
S
E
S
S
F
I
S
G
D
I
N
Site 103
S1154
Q
S
E
S
S
F
I
S
G
D
I
N
S
T
S
Site 104
S1159
F
I
S
G
D
I
N
S
T
S
T
L
N
Q
G
Site 105
S1161
S
G
D
I
N
S
T
S
T
L
N
Q
G
M
T
Site 106
T1168
S
T
L
N
Q
G
M
T
G
N
Y
L
L
T
N
Site 107
Y1171
N
Q
G
M
T
G
N
Y
L
L
T
N
P
L
L
Site 108
T1183
P
L
L
R
P
H
G
T
N
N
P
Y
N
T
L
Site 109
S1207
P
S
A
P
V
F
N
S
P
G
H
S
L
N
N
Site 110
S1211
V
F
N
S
P
G
H
S
L
N
N
A
R
D
T
Site 111
T1218
S
L
N
N
A
R
D
T
S
A
M
D
T
L
P
Site 112
S1219
L
N
N
A
R
D
T
S
A
M
D
T
L
P
L
Site 113
T1223
R
D
T
S
A
M
D
T
L
P
L
N
G
N
F
Site 114
Y1234
N
G
N
F
N
N
S
Y
S
L
H
K
G
D
Y
Site 115
Y1241
Y
S
L
H
K
G
D
Y
N
D
S
V
Q
V
V
Site 116
S1275
V
H
N
N
L
R
G
S
S
K
T
H
N
L
E
Site 117
S1276
H
N
N
L
R
G
S
S
K
T
H
N
L
E
L
Site 118
T1278
N
L
R
G
S
S
K
T
H
N
L
E
L
T
L
Site 119
S1306
D
A
I
V
A
D
A
S
S
L
M
H
S
D
N
Site 120
S1307
A
I
V
A
D
A
S
S
L
M
H
S
D
N
P
Site 121
S1311
D
A
S
S
L
M
H
S
D
N
P
G
L
E
L
Site 122
S1334
L
I
P
Q
R
T
H
S
L
L
Y
Q
P
Q
K
Site 123
Y1337
Q
R
T
H
S
L
L
Y
Q
P
Q
K
K
V
K
Site 124
S1345
Q
P
Q
K
K
V
K
S
E
G
T
D
S
Y
V
Site 125
S1350
V
K
S
E
G
T
D
S
Y
V
S
Q
L
T
A
Site 126
Y1351
K
S
E
G
T
D
S
Y
V
S
Q
L
T
A
E
Site 127
S1365
E
A
E
D
H
L
Q
S
P
N
R
D
S
L
Y
Site 128
S1370
L
Q
S
P
N
R
D
S
L
Y
T
S
M
P
N
Site 129
Y1372
S
P
N
R
D
S
L
Y
T
S
M
P
N
L
R
Site 130
T1373
P
N
R
D
S
L
Y
T
S
M
P
N
L
R
D
Site 131
S1374
N
R
D
S
L
Y
T
S
M
P
N
L
R
D
S
Site 132
S1381
S
M
P
N
L
R
D
S
P
Y
P
E
S
S
P
Site 133
Y1383
P
N
L
R
D
S
P
Y
P
E
S
S
P
D
M
Site 134
S1386
R
D
S
P
Y
P
E
S
S
P
D
M
E
E
D
Site 135
S1387
D
S
P
Y
P
E
S
S
P
D
M
E
E
D
L
Site 136
S1395
P
D
M
E
E
D
L
S
P
S
R
R
S
E
N
Site 137
S1397
M
E
E
D
L
S
P
S
R
R
S
E
N
E
D
Site 138
S1400
D
L
S
P
S
R
R
S
E
N
E
D
I
Y
Y
Site 139
Y1406
R
S
E
N
E
D
I
Y
Y
K
S
M
P
N
L
Site 140
Y1407
S
E
N
E
D
I
Y
Y
K
S
M
P
N
L
G
Site 141
S1409
N
E
D
I
Y
Y
K
S
M
P
N
L
G
A
G
Site 142
Y1423
G
H
Q
L
Q
M
C
Y
Q
I
S
R
G
N
S
Site 143
S1430
Y
Q
I
S
R
G
N
S
D
G
Y
I
I
P
I
Site 144
Y1433
S
R
G
N
S
D
G
Y
I
I
P
I
N
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation