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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTRAP
Full Name:
Tyrosyl-DNA phosphodiesterase 2
Alias:
AD022; EAP2; EAPII; ETS1-associated protein 2; ETS1-associated protein II
Type:
Uncharacterized protein
Mass (Da):
40930
Number AA:
362
UniProt ID:
O95551
International Prot ID:
IPI00009913
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
Uniprot
OncoNet
Molecular Function:
GO:0070260
GO:0000287
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
GO:0006302
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y61
M
E
R
A
L
N
S
Y
F
E
P
P
V
E
E
Site 2
T77
A
L
E
R
R
P
E
T
I
S
E
P
K
T
Y
Site 3
S79
E
R
R
P
E
T
I
S
E
P
K
T
Y
V
D
Site 4
T83
E
T
I
S
E
P
K
T
Y
V
D
L
T
N
E
Site 5
Y84
T
I
S
E
P
K
T
Y
V
D
L
T
N
E
E
Site 6
T88
P
K
T
Y
V
D
L
T
N
E
E
T
T
D
S
Site 7
T92
V
D
L
T
N
E
E
T
T
D
S
T
T
S
K
Site 8
S95
T
N
E
E
T
T
D
S
T
T
S
K
I
S
P
Site 9
T96
N
E
E
T
T
D
S
T
T
S
K
I
S
P
S
Site 10
T97
E
E
T
T
D
S
T
T
S
K
I
S
P
S
E
Site 11
S98
E
T
T
D
S
T
T
S
K
I
S
P
S
E
D
Site 12
S101
D
S
T
T
S
K
I
S
P
S
E
D
T
Q
Q
Site 13
T106
K
I
S
P
S
E
D
T
Q
Q
E
N
G
S
M
Site 14
S130
G
L
D
L
N
N
L
S
E
R
A
R
G
V
C
Site 15
S138
E
R
A
R
G
V
C
S
Y
L
A
L
Y
S
P
Site 16
Y139
R
A
R
G
V
C
S
Y
L
A
L
Y
S
P
D
Site 17
Y157
L
Q
E
V
I
P
P
Y
Y
S
Y
L
K
K
R
Site 18
Y158
Q
E
V
I
P
P
Y
Y
S
Y
L
K
K
R
S
Site 19
S159
E
V
I
P
P
Y
Y
S
Y
L
K
K
R
S
S
Site 20
Y160
V
I
P
P
Y
Y
S
Y
L
K
K
R
S
S
N
Site 21
S166
S
Y
L
K
K
R
S
S
N
Y
E
I
I
T
G
Site 22
Y168
L
K
K
R
S
S
N
Y
E
I
I
T
G
H
E
Site 23
T180
G
H
E
E
G
Y
F
T
A
I
M
L
K
K
S
Site 24
S187
T
A
I
M
L
K
K
S
R
V
K
L
K
S
Q
Site 25
S193
K
S
R
V
K
L
K
S
Q
E
I
I
P
F
P
Site 26
S225
N
E
L
C
L
M
T
S
H
L
E
S
T
R
G
Site 27
S229
L
M
T
S
H
L
E
S
T
R
G
H
A
A
E
Site 28
S254
K
M
Q
E
A
P
E
S
A
T
V
I
F
A
G
Site 29
T271
N
L
R
D
R
E
V
T
R
C
G
G
L
P
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation