KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ETHE1
Full Name:
Protein ETHE1, mitochondrial
Alias:
ETHE1, mitochondrial; Ethylmalonic encephalopathy 1; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Hepatoma subtracted one; HSCO; YF13H12
Type:
Mitochondrial; Hydrolase; EC 3.-.-.-
Mass (Da):
27854
Number AA:
254
UniProt ID:
O95571
International Prot ID:
IPI00003766
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016787
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
V
A
R
R
Q
L
S
Q
R
G
G
S
G
A
Site 2
S19
Q
L
S
Q
R
G
G
S
G
A
P
I
L
L
R
Site 3
T37
E
P
V
S
C
T
F
T
Y
L
L
G
D
R
E
Site 4
S45
Y
L
L
G
D
R
E
S
R
E
A
V
L
I
D
Site 5
T86
H
C
H
A
D
H
I
T
G
S
G
L
L
R
S
Site 6
S103
P
G
C
Q
S
V
I
S
R
L
S
G
A
Q
A
Site 7
S106
Q
S
V
I
S
R
L
S
G
A
Q
A
D
L
H
Site 8
S119
L
H
I
E
D
G
D
S
I
R
F
G
R
F
A
Site 9
T129
F
G
R
F
A
L
E
T
R
A
S
P
G
H
T
Site 10
S132
F
A
L
E
T
R
A
S
P
G
H
T
P
G
C
Site 11
T136
T
R
A
S
P
G
H
T
P
G
C
V
T
F
V
Site 12
T141
G
H
T
P
G
C
V
T
F
V
L
N
D
H
S
Site 13
T152
N
D
H
S
M
A
F
T
G
D
A
L
L
I
R
Site 14
Y175
Q
G
C
A
K
T
L
Y
H
S
V
H
E
K
I
Site 15
Y192
L
P
G
D
C
L
I
Y
P
A
H
D
Y
H
G
Site 16
Y197
L
I
Y
P
A
H
D
Y
H
G
F
T
V
S
T
Site 17
T201
A
H
D
Y
H
G
F
T
V
S
T
V
E
E
E
Site 18
S203
D
Y
H
G
F
T
V
S
T
V
E
E
E
R
T
Site 19
T204
Y
H
G
F
T
V
S
T
V
E
E
E
R
T
L
Site 20
T210
S
T
V
E
E
E
R
T
L
N
P
R
L
T
L
Site 21
T216
R
T
L
N
P
R
L
T
L
S
C
E
E
F
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation