KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ACSL3
Full Name:
Long-chain-fatty-acid--CoA ligase 3
Alias:
ACS3; Acyl-CoA synthetase long-chain family member 3; FACL3; LACS 3; LACS3; LCF3; Long-chain acyl-CoA synthetase 3; PRO2194
Type:
EC 6.2.1.3; Lipid Metabolism - fatty acid; Ligase
Mass (Da):
80420
Number AA:
720
UniProt ID:
O95573
International Prot ID:
IPI00031397
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004321
GO:0004467
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
N
H
V
S
S
K
P
S
T
M
K
L
K
H
T
Site 2
T11
H
V
S
S
K
P
S
T
M
K
L
K
H
T
I
Site 3
S45
Y
I
P
F
Y
F
F
S
E
S
R
Q
E
K
S
Site 4
S47
P
F
Y
F
F
S
E
S
R
Q
E
K
S
N
R
Site 5
S52
S
E
S
R
Q
E
K
S
N
R
I
K
A
K
P
Site 6
S62
I
K
A
K
P
V
N
S
K
P
D
S
A
Y
R
Site 7
S66
P
V
N
S
K
P
D
S
A
Y
R
S
V
N
S
Site 8
Y68
N
S
K
P
D
S
A
Y
R
S
V
N
S
L
D
Site 9
S70
K
P
D
S
A
Y
R
S
V
N
S
L
D
G
L
Site 10
S73
S
A
Y
R
S
V
N
S
L
D
G
L
A
S
V
Site 11
T107
K
N
K
R
L
L
G
T
R
E
V
L
N
E
E
Site 12
Y132
K
K
V
I
L
G
Q
Y
N
W
L
S
Y
E
D
Site 13
Y137
G
Q
Y
N
W
L
S
Y
E
D
V
F
V
R
A
Site 14
T208
A
L
N
E
T
E
V
T
N
I
I
T
S
K
E
Site 15
S226
T
K
L
K
D
I
V
S
L
V
P
R
L
R
H
Site 16
T236
P
R
L
R
H
I
I
T
V
D
G
K
P
P
T
Site 17
T243
T
V
D
G
K
P
P
T
W
S
E
F
P
K
G
Site 18
S245
D
G
K
P
P
T
W
S
E
F
P
K
G
I
I
Site 19
S267
E
A
L
G
A
K
A
S
M
E
N
Q
P
H
S
Site 20
S274
S
M
E
N
Q
P
H
S
K
P
L
P
S
D
I
Site 21
Y351
S
H
G
C
R
I
G
Y
S
S
P
Q
T
L
A
Site 22
S352
H
G
C
R
I
G
Y
S
S
P
Q
T
L
A
D
Site 23
S353
G
C
R
I
G
Y
S
S
P
Q
T
L
A
D
Q
Site 24
T356
I
G
Y
S
S
P
Q
T
L
A
D
Q
S
S
K
Site 25
S362
Q
T
L
A
D
Q
S
S
K
I
K
K
G
S
K
Site 26
T372
K
K
G
S
K
G
D
T
S
M
L
K
P
T
L
Site 27
S373
K
G
S
K
G
D
T
S
M
L
K
P
T
L
M
Site 28
Y391
P
E
I
M
D
R
I
Y
K
N
V
M
N
K
V
Site 29
S399
K
N
V
M
N
K
V
S
E
M
S
S
F
Q
R
Site 30
S403
N
K
V
S
E
M
S
S
F
Q
R
N
L
F
I
Site 31
Y413
R
N
L
F
I
L
A
Y
N
Y
K
M
E
Q
I
Site 32
T426
Q
I
S
K
G
R
N
T
P
L
C
D
S
F
V
Site 33
S431
R
N
T
P
L
C
D
S
F
V
F
R
K
V
R
Site 34
T478
V
G
Q
G
Y
G
L
T
E
S
A
G
A
G
T
Site 35
S480
Q
G
Y
G
L
T
E
S
A
G
A
G
T
I
S
Site 36
S487
S
A
G
A
G
T
I
S
E
V
W
D
Y
N
T
Site 37
Y492
T
I
S
E
V
W
D
Y
N
T
G
R
V
G
A
Site 38
T494
S
E
V
W
D
Y
N
T
G
R
V
G
A
P
L
Site 39
Y516
K
N
W
E
E
G
G
Y
F
N
T
D
K
P
H
Site 40
T519
E
E
G
G
Y
F
N
T
D
K
P
H
P
R
G
Site 41
Y591
V
K
L
Q
A
G
E
Y
V
S
L
G
K
V
E
Site 42
S593
L
Q
A
G
E
Y
V
S
L
G
K
V
E
A
A
Site 43
Y613
L
V
D
N
I
C
A
Y
A
N
S
Y
H
S
Y
Site 44
S670
S
E
A
A
I
S
A
S
L
E
K
F
E
I
P
Site 45
S683
I
P
V
K
I
R
L
S
P
E
P
W
T
P
E
Site 46
T688
R
L
S
P
E
P
W
T
P
E
T
G
L
V
T
Site 47
T691
P
E
P
W
T
P
E
T
G
L
V
T
D
A
F
Site 48
T707
L
K
R
K
E
L
K
T
H
Y
Q
A
D
I
E
Site 49
Y709
R
K
E
L
K
T
H
Y
Q
A
D
I
E
R
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation