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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR1A
Full Name:
DNA-directed RNA polymerase I subunit RPA1
Alias:
DNA-directed RNA polymerase I subunit A; EC 2.7.7.6; RPA1
Type:
Transcription initiation complex
Mass (Da):
194811
Number AA:
1720
UniProt ID:
O95602
International Prot ID:
IPI00031960
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005736
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
W
R
R
L
Q
G
I
S
F
G
M
Y
S
A
E
Site 2
Y20
Q
G
I
S
F
G
M
Y
S
A
E
E
L
K
K
Site 3
S29
A
E
E
L
K
K
L
S
V
K
S
I
T
N
P
Site 4
S32
L
K
K
L
S
V
K
S
I
T
N
P
R
Y
L
Site 5
Y38
K
S
I
T
N
P
R
Y
L
D
S
L
G
N
P
Site 6
S41
T
N
P
R
Y
L
D
S
L
G
N
P
S
A
N
Site 7
Y51
N
P
S
A
N
G
L
Y
D
L
A
L
G
P
A
Site 8
T66
D
S
K
E
V
C
S
T
C
V
Q
D
F
S
N
Site 9
S153
L
E
E
N
P
D
P
S
A
S
E
I
R
E
E
Site 10
S155
E
N
P
D
P
S
A
S
E
I
R
E
E
L
E
Site 11
Y164
I
R
E
E
L
E
Q
Y
T
T
E
I
V
Q
N
Site 12
T166
E
E
L
E
Q
Y
T
T
E
I
V
Q
N
N
L
Site 13
S176
V
Q
N
N
L
L
G
S
Q
G
A
H
V
K
N
Site 14
T210
K
R
C
P
H
C
K
T
G
R
S
V
V
R
K
Site 15
S213
P
H
C
K
T
G
R
S
V
V
R
K
E
H
N
Site 16
S221
V
V
R
K
E
H
N
S
K
L
T
I
T
F
P
Site 17
T226
H
N
S
K
L
T
I
T
F
P
A
M
V
H
R
Site 18
S240
R
T
A
G
Q
K
D
S
E
P
L
G
I
E
E
Site 19
Y255
A
Q
I
G
K
R
G
Y
L
T
P
T
S
A
R
Site 20
T257
I
G
K
R
G
Y
L
T
P
T
S
A
R
E
H
Site 21
T259
K
R
G
Y
L
T
P
T
S
A
R
E
H
L
S
Site 22
S260
R
G
Y
L
T
P
T
S
A
R
E
H
L
S
A
Site 23
S266
T
S
A
R
E
H
L
S
A
L
W
K
N
E
G
Site 24
Y278
N
E
G
F
F
L
N
Y
L
F
S
G
M
D
D
Site 25
S307
D
F
L
V
V
P
P
S
R
Y
R
P
V
S
R
Site 26
Y309
L
V
V
P
P
S
R
Y
R
P
V
S
R
L
G
Site 27
S313
P
S
R
Y
R
P
V
S
R
L
G
D
Q
M
F
Site 28
T357
K
L
P
E
E
V
A
T
P
T
T
D
E
E
K
Site 29
T360
E
E
V
A
T
P
T
T
D
E
E
K
D
S
L
Site 30
S366
T
T
D
E
E
K
D
S
L
I
A
I
D
R
S
Site 31
S382
L
S
T
L
P
G
Q
S
L
I
D
K
L
Y
N
Site 32
Y388
Q
S
L
I
D
K
L
Y
N
I
W
I
R
L
Q
Site 33
Y414
D
K
L
M
M
D
K
Y
P
G
I
R
Q
I
L
Site 34
Y468
V
F
A
T
K
L
T
Y
P
Q
P
V
T
P
W
Site 35
T473
L
T
Y
P
Q
P
V
T
P
W
N
V
Q
E
L
Site 36
S508
D
G
S
R
T
A
L
S
A
V
D
M
T
Q
R
Site 37
T513
A
L
S
A
V
D
M
T
Q
R
E
A
V
A
K
Site 38
T527
K
Q
L
L
T
P
A
T
G
A
P
K
P
Q
G
Site 39
T555
L
L
L
N
R
Q
P
T
L
H
R
P
S
I
Q
Site 40
S560
Q
P
T
L
H
R
P
S
I
Q
A
H
R
A
R
Site 41
Y579
E
K
V
L
R
L
H
Y
A
N
C
K
A
Y
N
Site 42
Y585
H
Y
A
N
C
K
A
Y
N
A
D
F
D
G
D
Site 43
S601
M
N
A
H
F
P
Q
S
E
L
G
R
A
E
A
Site 44
Y609
E
L
G
R
A
E
A
Y
V
L
A
C
T
D
Q
Site 45
Y618
L
A
C
T
D
Q
Q
Y
L
V
P
K
D
G
Q
Site 46
Y653
C
F
F
T
R
E
H
Y
M
E
L
V
Y
R
G
Site 47
T662
E
L
V
Y
R
G
L
T
D
K
V
G
R
V
K
Site 48
S706
D
H
I
P
L
N
L
S
G
K
A
K
I
T
G
Site 49
T720
G
K
A
W
V
K
E
T
P
R
S
V
P
G
F
Site 50
S723
W
V
K
E
T
P
R
S
V
P
G
F
N
P
D
Site 51
S731
V
P
G
F
N
P
D
S
M
C
E
S
Q
V
I
Site 52
S735
N
P
D
S
M
C
E
S
Q
V
I
I
R
E
G
Site 53
Y754
G
V
L
D
K
A
H
Y
G
S
S
A
Y
G
L
Site 54
Y769
V
H
C
C
Y
E
I
Y
G
G
E
T
S
G
K
Site 55
S819
R
Q
R
I
I
E
E
S
T
H
C
G
P
Q
A
Site 56
Y839
N
L
P
E
A
A
S
Y
D
E
V
R
G
K
W
Site 57
Y872
F
K
E
E
V
N
H
Y
S
N
E
I
N
K
A
Site 58
S873
K
E
E
V
N
H
Y
S
N
E
I
N
K
A
C
Site 59
S931
R
R
P
P
L
M
A
S
G
K
S
L
P
C
F
Site 60
S934
P
L
M
A
S
G
K
S
L
P
C
F
E
P
Y
Site 61
Y941
S
L
P
C
F
E
P
Y
E
F
T
P
R
A
G
Site 62
T944
C
F
E
P
Y
E
F
T
P
R
A
G
G
F
V
Site 63
T978
G
R
E
G
L
V
D
T
A
V
K
T
S
R
S
Site 64
Y987
V
K
T
S
R
S
G
Y
L
Q
R
C
I
I
K
Site 65
T1006
L
V
V
Q
Y
D
L
T
V
R
D
S
D
G
S
Site 66
S1010
Y
D
L
T
V
R
D
S
D
G
S
V
V
Q
F
Site 67
S1013
T
V
R
D
S
D
G
S
V
V
Q
F
L
Y
G
Site 68
T1029
D
G
L
D
I
P
K
T
Q
F
L
Q
P
K
Q
Site 69
S1042
K
Q
F
P
F
L
A
S
N
Y
E
V
I
M
K
Site 70
S1058
Q
H
L
H
E
V
L
S
R
A
D
P
K
K
A
Site 71
T1082
W
Q
S
K
H
P
N
T
L
L
R
R
G
A
F
Site 72
S1091
L
R
R
G
A
F
L
S
Y
S
Q
K
I
Q
E
Site 73
Y1092
R
R
G
A
F
L
S
Y
S
Q
K
I
Q
E
A
Site 74
S1093
R
G
A
F
L
S
Y
S
Q
K
I
Q
E
A
V
Site 75
S1107
V
K
A
L
K
L
E
S
E
N
R
N
G
R
S
Site 76
S1114
S
E
N
R
N
G
R
S
P
G
T
Q
E
M
L
Site 77
T1117
R
N
G
R
S
P
G
T
Q
E
M
L
R
M
W
Site 78
Y1125
Q
E
M
L
R
M
W
Y
E
L
D
E
E
S
R
Site 79
S1131
W
Y
E
L
D
E
E
S
R
R
K
Y
Q
K
K
Site 80
Y1135
D
E
E
S
R
R
K
Y
Q
K
K
A
A
A
C
Site 81
S1146
A
A
A
C
P
D
P
S
L
S
V
W
R
P
D
Site 82
S1148
A
C
P
D
P
S
L
S
V
W
R
P
D
I
Y
Site 83
Y1155
S
V
W
R
P
D
I
Y
F
A
S
V
S
E
T
Site 84
S1158
R
P
D
I
Y
F
A
S
V
S
E
T
F
E
T
Site 85
S1160
D
I
Y
F
A
S
V
S
E
T
F
E
T
K
V
Site 86
T1162
Y
F
A
S
V
S
E
T
F
E
T
K
V
D
D
Site 87
T1165
S
V
S
E
T
F
E
T
K
V
D
D
Y
S
Q
Site 88
Y1170
F
E
T
K
V
D
D
Y
S
Q
E
W
A
A
Q
Site 89
S1171
E
T
K
V
D
D
Y
S
Q
E
W
A
A
Q
T
Site 90
S1181
W
A
A
Q
T
E
K
S
Y
E
K
S
E
L
S
Site 91
S1185
T
E
K
S
Y
E
K
S
E
L
S
L
D
R
L
Site 92
S1188
S
Y
E
K
S
E
L
S
L
D
R
L
R
T
L
Site 93
T1194
L
S
L
D
R
L
R
T
L
L
Q
L
K
W
Q
Site 94
S1203
L
Q
L
K
W
Q
R
S
L
C
E
P
G
E
A
Site 95
T1227
G
E
P
S
T
Q
M
T
L
N
T
F
H
F
A
Site 96
T1230
S
T
Q
M
T
L
N
T
F
H
F
A
G
R
G
Site 97
T1242
G
R
G
E
M
N
V
T
L
G
I
P
R
L
R
Site 98
S1280
K
A
L
K
R
V
K
S
L
K
K
Q
L
T
R
Site 99
T1286
K
S
L
K
K
Q
L
T
R
V
C
L
G
E
V
Site 100
Y1315
K
Q
N
K
F
Q
V
Y
Q
L
R
F
Q
F
L
Site 101
Y1327
Q
F
L
P
H
A
Y
Y
Q
Q
E
K
C
L
R
Site 102
S1353
F
F
K
L
L
M
E
S
I
K
K
K
N
N
K
Site 103
S1362
K
K
K
N
N
K
A
S
A
F
R
N
V
N
T
Site 104
T1373
N
V
N
T
R
R
A
T
Q
R
D
L
D
N
A
Site 105
S1386
N
A
G
E
L
G
R
S
R
G
E
Q
E
G
D
Site 106
S1413
E
E
G
D
A
D
A
S
D
A
K
R
K
E
K
Site 107
Y1427
K
Q
E
E
E
V
D
Y
E
S
E
E
E
E
E
Site 108
S1429
E
E
E
V
D
Y
E
S
E
E
E
E
E
R
E
Site 109
T1459
H
R
E
G
A
R
K
T
Q
E
Q
D
E
E
V
Site 110
S1475
L
G
T
E
E
D
P
S
L
P
A
L
L
T
Q
Site 111
T1481
P
S
L
P
A
L
L
T
Q
P
R
K
P
T
H
Site 112
T1487
L
T
Q
P
R
K
P
T
H
S
Q
E
P
Q
G
Site 113
S1489
Q
P
R
K
P
T
H
S
Q
E
P
Q
G
P
E
Site 114
Y1515
I
H
P
F
I
D
D
Y
Q
Y
D
T
E
E
S
Site 115
Y1517
P
F
I
D
D
Y
Q
Y
D
T
E
E
S
L
W
Site 116
S1546
D
M
S
S
L
V
V
S
L
A
H
G
A
V
I
Site 117
Y1554
L
A
H
G
A
V
I
Y
A
T
K
G
I
T
R
Site 118
T1580
E
K
E
L
V
L
N
T
E
G
I
N
L
P
E
Site 119
Y1591
N
L
P
E
L
F
K
Y
A
E
V
L
D
L
R
Site 120
S1602
L
D
L
R
R
L
Y
S
N
D
I
H
A
I
A
Site 121
S1664
L
N
R
F
G
I
R
S
N
S
S
P
L
Q
Q
Site 122
S1666
R
F
G
I
R
S
N
S
S
P
L
Q
Q
M
T
Site 123
S1667
F
G
I
R
S
N
S
S
P
L
Q
Q
M
T
F
Site 124
T1673
S
S
P
L
Q
Q
M
T
F
E
T
S
F
Q
F
Site 125
S1695
G
S
H
D
E
L
R
S
P
S
A
C
L
V
V
Site 126
S1697
H
D
E
L
R
S
P
S
A
C
L
V
V
G
K
Site 127
T1710
G
K
V
V
R
G
G
T
G
L
F
E
L
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation