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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY5
Full Name:
Adenylate cyclase type 5
Alias:
Adenylyl cyclase 5; ATP pyrophosphate-lyase 5; EC 4.6.1.1
Type:
Membrane, Integral membrane protein
Mass (Da):
138908
Number AA:
1261
UniProt ID:
O95622
International Prot ID:
IPI00339214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004016
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
G
S
K
S
V
S
P
P
G
Y
A
Site 2
S8
M
S
G
S
K
S
V
S
P
P
G
Y
A
A
Q
Site 3
Y12
K
S
V
S
P
P
G
Y
A
A
Q
K
T
A
A
Site 4
T17
P
G
Y
A
A
Q
K
T
A
A
P
A
P
R
G
Site 5
S30
R
G
G
P
E
H
R
S
A
W
G
E
A
D
S
Site 6
S37
S
A
W
G
E
A
D
S
R
A
N
G
Y
P
H
Site 7
Y42
A
D
S
R
A
N
G
Y
P
H
A
P
G
G
S
Site 8
S49
Y
P
H
A
P
G
G
S
A
R
G
S
T
K
K
Site 9
S53
P
G
G
S
A
R
G
S
T
K
K
P
G
G
A
Site 10
T54
G
G
S
A
R
G
S
T
K
K
P
G
G
A
V
Site 11
T62
K
K
P
G
G
A
V
T
P
Q
Q
Q
Q
R
L
Site 12
S71
Q
Q
Q
Q
R
L
A
S
R
W
R
S
D
D
D
Site 13
S75
R
L
A
S
R
W
R
S
D
D
D
D
D
P
P
Site 14
S84
D
D
D
D
P
P
L
S
G
D
D
P
L
A
G
Site 15
S96
L
A
G
G
F
G
F
S
F
R
S
K
S
A
W
Site 16
S99
G
F
G
F
S
F
R
S
K
S
A
W
Q
E
R
Site 17
S101
G
F
S
F
R
S
K
S
A
W
Q
E
R
G
G
Site 18
S115
G
D
D
C
G
R
G
S
R
R
Q
R
R
G
A
Site 19
S124
R
Q
R
R
G
A
A
S
G
G
S
T
R
A
P
Site 20
S127
R
G
A
A
S
G
G
S
T
R
A
P
P
A
G
Site 21
T128
G
A
A
S
G
G
S
T
R
A
P
P
A
G
G
Site 22
T149
A
A
A
S
A
G
G
T
E
V
R
P
R
S
V
Site 23
S155
G
T
E
V
R
P
R
S
V
E
V
G
L
E
E
Site 24
S184
A
V
E
G
G
E
G
S
G
D
G
G
S
S
A
Site 25
S189
E
G
S
G
D
G
G
S
S
A
D
S
G
S
G
Site 26
S190
G
S
G
D
G
G
S
S
A
D
S
G
S
G
A
Site 27
S193
D
G
G
S
S
A
D
S
G
S
G
A
G
P
G
Site 28
S195
G
S
S
A
D
S
G
S
G
A
G
P
G
A
V
Site 29
S218
A
L
L
Q
I
F
R
S
K
K
F
P
S
D
K
Site 30
S223
F
R
S
K
K
F
P
S
D
K
L
E
R
L
Y
Site 31
Y230
S
D
K
L
E
R
L
Y
Q
R
Y
F
F
R
L
Site 32
Y233
L
E
R
L
Y
Q
R
Y
F
F
R
L
N
Q
S
Site 33
S324
L
L
L
P
Q
P
R
S
A
S
E
G
I
W
W
Site 34
S326
L
P
Q
P
R
S
A
S
E
G
I
W
W
T
V
Site 35
T368
H
L
A
I
A
L
R
T
N
A
Q
D
Q
F
L
Site 36
S403
T
H
Y
P
A
E
V
S
Q
R
Q
A
F
Q
E
Site 37
S421
C
I
Q
A
R
L
H
S
Q
R
E
N
Q
Q
Q
Site 38
S434
Q
Q
E
R
L
L
L
S
V
L
P
R
H
V
A
Site 39
S483
E
G
F
T
S
L
A
S
Q
C
T
A
Q
E
L
Site 40
S567
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
Site 41
Y618
L
N
Y
L
N
G
D
Y
E
V
E
P
G
C
G
Site 42
Y631
C
G
G
E
R
N
A
Y
L
K
E
H
S
I
E
Site 43
T646
T
F
L
I
L
R
C
T
Q
K
R
K
E
E
K
Site 44
T664
A
K
M
N
R
Q
R
T
N
S
I
G
H
N
P
Site 45
S666
M
N
R
Q
R
T
N
S
I
G
H
N
P
P
H
Site 46
Y681
W
G
A
E
R
P
F
Y
N
H
L
G
G
N
Q
Site 47
S690
H
L
G
G
N
Q
V
S
K
E
M
K
R
M
G
Site 48
S728
G
R
A
I
D
A
R
S
I
D
R
L
R
S
E
Site 49
S734
R
S
I
D
R
L
R
S
E
H
V
R
K
F
L
Site 50
T743
H
V
R
K
F
L
L
T
F
R
E
P
D
L
E
Site 51
S754
P
D
L
E
K
K
Y
S
K
Q
V
D
D
R
F
Site 52
S818
S
C
V
K
L
F
P
S
P
L
Q
T
L
S
R
Site 53
T822
L
F
P
S
P
L
Q
T
L
S
R
K
I
V
R
Site 54
S824
P
S
P
L
Q
T
L
S
R
K
I
V
R
S
K
Site 55
S830
L
S
R
K
I
V
R
S
K
M
N
S
T
L
V
Site 56
T1011
H
A
Q
Q
V
E
S
T
A
R
L
D
F
L
W
Site 57
Y1035
E
M
E
E
L
Q
A
Y
N
R
R
L
L
H
N
Site 58
Y1063
E
R
R
N
D
E
L
Y
Y
Q
S
C
E
C
V
Site 59
Y1064
R
R
N
D
E
L
Y
Y
Q
S
C
E
C
V
A
Site 60
Y1084
I
A
N
F
S
E
F
Y
V
E
L
E
A
N
N
Site 61
S1112
A
D
F
D
E
I
I
S
E
D
R
F
R
Q
L
Site 62
T1124
R
Q
L
E
K
I
K
T
I
G
S
T
Y
M
A
Site 63
S1133
G
S
T
Y
M
A
A
S
G
L
N
D
S
T
Y
Site 64
S1138
A
A
S
G
L
N
D
S
T
Y
D
K
V
G
K
Site 65
T1139
A
S
G
L
N
D
S
T
Y
D
K
V
G
K
T
Site 66
Y1140
S
G
L
N
D
S
T
Y
D
K
V
G
K
T
H
Site 67
T1146
T
Y
D
K
V
G
K
T
H
I
K
A
L
A
D
Site 68
Y1164
K
L
M
D
Q
M
K
Y
I
N
E
H
S
F
N
Site 69
S1169
M
K
Y
I
N
E
H
S
F
N
N
F
Q
M
K
Site 70
Y1196
I
G
A
R
K
P
Q
Y
D
I
W
G
N
T
V
Site 71
S1207
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
Site 72
S1211
N
V
A
S
R
M
D
S
T
G
V
P
D
R
I
Site 73
T1212
V
A
S
R
M
D
S
T
G
V
P
D
R
I
Q
Site 74
T1222
P
D
R
I
Q
V
T
T
D
M
Y
Q
V
L
A
Site 75
T1251
K
G
K
G
E
M
M
T
Y
F
L
N
G
G
P
Site 76
Y1252
G
K
G
E
M
M
T
Y
F
L
N
G
G
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation