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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOT4
Full Name:
CCR4-NOT transcription complex subunit 4
Alias:
CCR4-associated factor 4; CCR4-NOT transcription 4; CCR4-NOT transcription complex, subunit 4; CLONE243; CNO4; CNOT4; E3 ubiquitin protein ligase CNOT4; negative regulator of transcription 4; NOT4H; transcriptional repressor NOT4Hp
Type:
EC 6.3.2.-; Ubiquitin conjugating system; Ligase
Mass (Da):
63510
Number AA:
575
UniProt ID:
O95628
International Prot ID:
IPI00410681
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0016874
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
R
S
P
D
A
K
E
Site 2
Y60
C
P
A
C
R
K
P
Y
P
E
D
P
A
V
Y
Site 3
S71
P
A
V
Y
K
P
L
S
Q
E
E
L
Q
R
I
Site 4
S94
N
E
R
K
Q
K
I
S
E
N
R
K
H
L
A
Site 5
S102
E
N
R
K
H
L
A
S
V
R
V
V
Q
K
N
Site 6
Y131
E
V
L
K
R
P
E
Y
F
G
K
F
G
K
I
Site 7
S146
H
K
V
V
I
N
N
S
T
S
Y
A
G
S
Q
Site 8
S148
V
V
I
N
N
S
T
S
Y
A
G
S
Q
G
P
Site 9
Y149
V
I
N
N
S
T
S
Y
A
G
S
Q
G
P
S
Site 10
S152
N
S
T
S
Y
A
G
S
Q
G
P
S
A
S
A
Site 11
S156
Y
A
G
S
Q
G
P
S
A
S
A
Y
V
T
Y
Site 12
S158
G
S
Q
G
P
S
A
S
A
Y
V
T
Y
I
R
Site 13
Y160
Q
G
P
S
A
S
A
Y
V
T
Y
I
R
S
E
Site 14
T162
P
S
A
S
A
Y
V
T
Y
I
R
S
E
D
A
Site 15
Y163
S
A
S
A
Y
V
T
Y
I
R
S
E
D
A
L
Site 16
S189
D
G
R
T
L
K
A
S
L
G
T
T
K
Y
C
Site 17
Y195
A
S
L
G
T
T
K
Y
C
S
Y
F
L
K
N
Site 18
Y212
C
P
K
P
D
C
M
Y
L
H
E
L
G
D
E
Site 19
S222
E
L
G
D
E
A
A
S
F
T
K
E
E
M
Q
Site 20
Y245
Q
K
L
L
Q
E
L
Y
K
L
N
P
N
F
L
Site 21
S255
N
P
N
F
L
Q
L
S
T
G
S
V
D
K
N
Site 22
T267
D
K
N
K
N
K
V
T
P
L
Q
R
Y
D
T
Site 23
Y272
K
V
T
P
L
Q
R
Y
D
T
P
I
D
K
P
Site 24
T274
T
P
L
Q
R
Y
D
T
P
I
D
K
P
S
D
Site 25
S280
D
T
P
I
D
K
P
S
D
S
L
S
I
G
N
Site 26
S282
P
I
D
K
P
S
D
S
L
S
I
G
N
G
D
Site 27
S284
D
K
P
S
D
S
L
S
I
G
N
G
D
N
S
Site 28
S291
S
I
G
N
G
D
N
S
Q
Q
I
S
N
S
D
Site 29
S295
G
D
N
S
Q
Q
I
S
N
S
D
T
P
S
P
Site 30
S297
N
S
Q
Q
I
S
N
S
D
T
P
S
P
P
P
Site 31
T299
Q
Q
I
S
N
S
D
T
P
S
P
P
P
G
L
Site 32
S301
I
S
N
S
D
T
P
S
P
P
P
G
L
S
K
Site 33
S307
P
S
P
P
P
G
L
S
K
S
N
P
V
I
P
Site 34
S309
P
P
P
G
L
S
K
S
N
P
V
I
P
I
S
Site 35
S316
S
N
P
V
I
P
I
S
S
S
N
H
S
A
R
Site 36
S317
N
P
V
I
P
I
S
S
S
N
H
S
A
R
S
Site 37
S318
P
V
I
P
I
S
S
S
N
H
S
A
R
S
P
Site 38
S321
P
I
S
S
S
N
H
S
A
R
S
P
F
E
G
Site 39
S324
S
S
N
H
S
A
R
S
P
F
E
G
A
V
T
Site 40
T331
S
P
F
E
G
A
V
T
E
S
Q
S
L
F
S
Site 41
S333
F
E
G
A
V
T
E
S
Q
S
L
F
S
D
N
Site 42
S335
G
A
V
T
E
S
Q
S
L
F
S
D
N
F
R
Site 43
S349
R
H
P
N
P
I
P
S
G
L
P
P
F
P
S
Site 44
S356
S
G
L
P
P
F
P
S
S
P
Q
T
S
S
D
Site 45
S357
G
L
P
P
F
P
S
S
P
Q
T
S
S
D
W
Site 46
T360
P
F
P
S
S
P
Q
T
S
S
D
W
P
T
A
Site 47
S361
F
P
S
S
P
Q
T
S
S
D
W
P
T
A
P
Site 48
S362
P
S
S
P
Q
T
S
S
D
W
P
T
A
P
E
Site 49
T366
Q
T
S
S
D
W
P
T
A
P
E
P
Q
S
L
Site 50
S372
P
T
A
P
E
P
Q
S
L
F
T
S
E
T
I
Site 51
S376
E
P
Q
S
L
F
T
S
E
T
I
P
V
S
S
Site 52
T378
Q
S
L
F
T
S
E
T
I
P
V
S
S
S
T
Site 53
S382
T
S
E
T
I
P
V
S
S
S
T
D
W
Q
A
Site 54
S384
E
T
I
P
V
S
S
S
T
D
W
Q
A
A
F
Site 55
S396
A
A
F
G
F
G
S
S
K
Q
P
E
D
D
L
Site 56
S424
D
L
I
E
K
E
L
S
V
Q
D
Q
P
S
L
Site 57
S430
L
S
V
Q
D
Q
P
S
L
S
P
T
S
L
Q
Site 58
S432
V
Q
D
Q
P
S
L
S
P
T
S
L
Q
N
S
Site 59
T434
D
Q
P
S
L
S
P
T
S
L
Q
N
S
S
S
Site 60
S435
Q
P
S
L
S
P
T
S
L
Q
N
S
S
S
H
Site 61
S439
S
P
T
S
L
Q
N
S
S
S
H
T
T
T
A
Site 62
S441
T
S
L
Q
N
S
S
S
H
T
T
T
A
K
G
Site 63
T443
L
Q
N
S
S
S
H
T
T
T
A
K
G
P
G
Site 64
T444
Q
N
S
S
S
H
T
T
T
A
K
G
P
G
S
Site 65
T445
N
S
S
S
H
T
T
T
A
K
G
P
G
S
G
Site 66
S451
T
T
A
K
G
P
G
S
G
F
L
H
P
A
A
Site 67
T460
F
L
H
P
A
A
A
T
N
A
N
S
L
N
S
Site 68
S467
T
N
A
N
S
L
N
S
T
F
S
V
L
P
Q
Site 69
T468
N
A
N
S
L
N
S
T
F
S
V
L
P
Q
R
Site 70
S470
N
S
L
N
S
T
F
S
V
L
P
Q
R
F
P
Site 71
Y486
F
Q
Q
H
R
A
V
Y
N
S
F
S
F
P
G
Site 72
S488
Q
H
R
A
V
Y
N
S
F
S
F
P
G
Q
A
Site 73
S490
R
A
V
Y
N
S
F
S
F
P
G
Q
A
A
R
Site 74
Y498
F
P
G
Q
A
A
R
Y
P
W
M
A
F
P
R
Site 75
T514
S
I
M
H
L
N
H
T
A
N
P
T
S
N
S
Site 76
S519
N
H
T
A
N
P
T
S
N
S
N
F
L
D
L
Site 77
S550
G
E
E
E
V
K
V
S
T
M
P
L
S
T
S
Site 78
T551
E
E
E
V
K
V
S
T
M
P
L
S
T
S
S
Site 79
S555
K
V
S
T
M
P
L
S
T
S
S
H
S
L
Q
Site 80
T556
V
S
T
M
P
L
S
T
S
S
H
S
L
Q
Q
Site 81
S557
S
T
M
P
L
S
T
S
S
H
S
L
Q
Q
G
Site 82
S558
T
M
P
L
S
T
S
S
H
S
L
Q
Q
G
Q
Site 83
S560
P
L
S
T
S
S
H
S
L
Q
Q
G
Q
Q
P
Site 84
S569
Q
Q
G
Q
Q
P
T
S
L
H
T
T
V
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation