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Updated November 2019
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Protein Info
Short Name:
NFAT2
Full Name:
Nuclear factor of activated T-cells, cytoplasmic 1
Alias:
NFAC1; NFAT transcription complex cytosolic component; NFAT transcription complex cytosolic component;NF-ATc1;NF-ATc;NFATc; NFATC; NF-ATc; NFATC1; NF-ATc1; NFC1; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Type:
Transcription protein
Mass (Da):
101243
Number AA:
943
UniProt ID:
O95644
International Prot ID:
IPI00032069
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005528
GO:0005515
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006355
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
T
S
F
P
V
P
S
K
F
P
L
G
P
A
Site 2
T26
A
V
F
G
R
G
E
T
L
G
P
A
P
R
A
Site 3
S39
R
A
G
G
T
M
K
S
A
E
E
E
H
Y
G
Site 4
Y45
K
S
A
E
E
E
H
Y
G
Y
A
S
S
N
V
Site 5
Y47
A
E
E
E
H
Y
G
Y
A
S
S
N
V
S
P
Site 6
S49
E
E
H
Y
G
Y
A
S
S
N
V
S
P
A
L
Site 7
S50
E
H
Y
G
Y
A
S
S
N
V
S
P
A
L
P
Site 8
S53
G
Y
A
S
S
N
V
S
P
A
L
P
L
P
T
Site 9
T64
P
L
P
T
A
H
S
T
L
P
A
P
C
H
N
Site 10
T74
A
P
C
H
N
L
Q
T
S
T
P
G
I
I
P
Site 11
S75
P
C
H
N
L
Q
T
S
T
P
G
I
I
P
P
Site 12
T76
C
H
N
L
Q
T
S
T
P
G
I
I
P
P
A
Site 13
Y100
L
D
G
G
P
A
G
Y
F
L
S
S
G
H
T
Site 14
S103
G
P
A
G
Y
F
L
S
S
G
H
T
R
P
D
Site 15
S104
P
A
G
Y
F
L
S
S
G
H
T
R
P
D
G
Site 16
T107
Y
F
L
S
S
G
H
T
R
P
D
G
A
P
A
Site 17
S117
D
G
A
P
A
L
E
S
P
R
I
E
I
T
S
Site 18
T123
E
S
P
R
I
E
I
T
S
C
L
G
L
Y
H
Site 19
S124
S
P
R
I
E
I
T
S
C
L
G
L
Y
H
N
Site 20
Y129
I
T
S
C
L
G
L
Y
H
N
N
N
Q
F
F
Site 21
S147
E
V
E
D
V
L
P
S
S
K
R
S
P
S
T
Site 22
S148
V
E
D
V
L
P
S
S
K
R
S
P
S
T
A
Site 23
S151
V
L
P
S
S
K
R
S
P
S
T
A
T
L
S
Site 24
S153
P
S
S
K
R
S
P
S
T
A
T
L
S
L
P
Site 25
T154
S
S
K
R
S
P
S
T
A
T
L
S
L
P
S
Site 26
S158
S
P
S
T
A
T
L
S
L
P
S
L
E
A
Y
Site 27
Y165
S
L
P
S
L
E
A
Y
R
D
P
S
C
L
S
Site 28
S169
L
E
A
Y
R
D
P
S
C
L
S
P
A
S
S
Site 29
S172
Y
R
D
P
S
C
L
S
P
A
S
S
L
S
S
Site 30
S175
P
S
C
L
S
P
A
S
S
L
S
S
R
S
C
Site 31
S176
S
C
L
S
P
A
S
S
L
S
S
R
S
C
N
Site 32
S178
L
S
P
A
S
S
L
S
S
R
S
C
N
S
E
Site 33
S179
S
P
A
S
S
L
S
S
R
S
C
N
S
E
A
Site 34
S181
A
S
S
L
S
S
R
S
C
N
S
E
A
S
S
Site 35
S184
L
S
S
R
S
C
N
S
E
A
S
S
Y
E
S
Site 36
S187
R
S
C
N
S
E
A
S
S
Y
E
S
N
Y
S
Site 37
S188
S
C
N
S
E
A
S
S
Y
E
S
N
Y
S
Y
Site 38
Y189
C
N
S
E
A
S
S
Y
E
S
N
Y
S
Y
P
Site 39
S191
S
E
A
S
S
Y
E
S
N
Y
S
Y
P
Y
A
Site 40
Y193
A
S
S
Y
E
S
N
Y
S
Y
P
Y
A
S
P
Site 41
S194
S
S
Y
E
S
N
Y
S
Y
P
Y
A
S
P
Q
Site 42
Y195
S
Y
E
S
N
Y
S
Y
P
Y
A
S
P
Q
T
Site 43
Y197
E
S
N
Y
S
Y
P
Y
A
S
P
Q
T
S
P
Site 44
S199
N
Y
S
Y
P
Y
A
S
P
Q
T
S
P
W
Q
Site 45
S203
P
Y
A
S
P
Q
T
S
P
W
Q
S
P
C
V
Site 46
S207
P
Q
T
S
P
W
Q
S
P
C
V
S
P
K
T
Site 47
S211
P
W
Q
S
P
C
V
S
P
K
T
T
D
P
E
Site 48
T214
S
P
C
V
S
P
K
T
T
D
P
E
E
G
F
Site 49
T215
P
C
V
S
P
K
T
T
D
P
E
E
G
F
P
Site 50
T229
P
R
G
L
G
A
C
T
L
L
G
S
P
R
H
Site 51
S233
G
A
C
T
L
L
G
S
P
R
H
S
P
S
T
Site 52
S237
L
L
G
S
P
R
H
S
P
S
T
S
P
R
A
Site 53
S239
G
S
P
R
H
S
P
S
T
S
P
R
A
S
V
Site 54
T240
S
P
R
H
S
P
S
T
S
P
R
A
S
V
T
Site 55
S241
P
R
H
S
P
S
T
S
P
R
A
S
V
T
E
Site 56
S245
P
S
T
S
P
R
A
S
V
T
E
E
S
W
L
Site 57
T247
T
S
P
R
A
S
V
T
E
E
S
W
L
G
A
Site 58
S256
E
S
W
L
G
A
R
S
S
R
P
A
S
P
C
Site 59
S257
S
W
L
G
A
R
S
S
R
P
A
S
P
C
N
Site 60
S261
A
R
S
S
R
P
A
S
P
C
N
K
R
K
Y
Site 61
Y268
S
P
C
N
K
R
K
Y
S
L
N
G
R
Q
P
Site 62
S269
P
C
N
K
R
K
Y
S
L
N
G
R
Q
P
P
Site 63
Y277
L
N
G
R
Q
P
P
Y
S
P
H
H
S
P
T
Site 64
S278
N
G
R
Q
P
P
Y
S
P
H
H
S
P
T
P
Site 65
S282
P
P
Y
S
P
H
H
S
P
T
P
S
P
H
G
Site 66
T284
Y
S
P
H
H
S
P
T
P
S
P
H
G
S
P
Site 67
S286
P
H
H
S
P
T
P
S
P
H
G
S
P
R
V
Site 68
S290
P
T
P
S
P
H
G
S
P
R
V
S
V
T
D
Site 69
S294
P
H
G
S
P
R
V
S
V
T
D
D
S
W
L
Site 70
T296
G
S
P
R
V
S
V
T
D
D
S
W
L
G
N
Site 71
S299
R
V
S
V
T
D
D
S
W
L
G
N
T
T
Q
Site 72
T305
D
S
W
L
G
N
T
T
Q
Y
T
S
S
A
I
Site 73
S323
I
N
A
L
T
T
D
S
S
L
D
L
G
D
G
Site 74
S324
N
A
L
T
T
D
S
S
L
D
L
G
D
G
V
Site 75
S335
G
D
G
V
P
V
K
S
R
K
T
T
L
E
Q
Site 76
T338
V
P
V
K
S
R
K
T
T
L
E
Q
P
P
S
Site 77
T339
P
V
K
S
R
K
T
T
L
E
Q
P
P
S
V
Site 78
S345
T
T
L
E
Q
P
P
S
V
A
L
K
V
E
P
Site 79
S359
P
V
G
E
D
L
G
S
P
P
P
P
A
D
F
Site 80
Y371
A
D
F
A
P
E
D
Y
S
S
F
Q
H
I
R
Site 81
S372
D
F
A
P
E
D
Y
S
S
F
Q
H
I
R
K
Site 82
S373
F
A
P
E
D
Y
S
S
F
Q
H
I
R
K
G
Site 83
Y386
K
G
G
F
C
D
Q
Y
L
A
V
P
Q
H
P
Site 84
Y394
L
A
V
P
Q
H
P
Y
Q
W
A
K
P
K
P
Site 85
S403
W
A
K
P
K
P
L
S
P
T
S
Y
M
S
P
Site 86
T405
K
P
K
P
L
S
P
T
S
Y
M
S
P
T
L
Site 87
S406
P
K
P
L
S
P
T
S
Y
M
S
P
T
L
P
Site 88
Y407
K
P
L
S
P
T
S
Y
M
S
P
T
L
P
A
Site 89
S409
L
S
P
T
S
Y
M
S
P
T
L
P
A
L
D
Site 90
T411
P
T
S
Y
M
S
P
T
L
P
A
L
D
W
Q
Site 91
S421
A
L
D
W
Q
L
P
S
H
S
G
P
Y
E
L
Site 92
S423
D
W
Q
L
P
S
H
S
G
P
Y
E
L
R
I
Site 93
Y426
L
P
S
H
S
G
P
Y
E
L
R
I
E
V
Q
Site 94
Y442
K
S
H
H
R
A
H
Y
E
T
E
G
S
R
G
Site 95
T444
H
H
R
A
H
Y
E
T
E
G
S
R
G
A
V
Site 96
Y466
P
I
V
Q
L
H
G
Y
L
E
N
E
P
L
M
Site 97
Y492
L
L
R
P
H
A
F
Y
Q
V
H
R
I
T
G
Site 98
T498
F
Y
Q
V
H
R
I
T
G
K
T
V
S
T
T
Site 99
T501
V
H
R
I
T
G
K
T
V
S
T
T
S
H
E
Site 100
S503
R
I
T
G
K
T
V
S
T
T
S
H
E
A
I
Site 101
T504
I
T
G
K
T
V
S
T
T
S
H
E
A
I
L
Site 102
S506
G
K
T
V
S
T
T
S
H
E
A
I
L
S
N
Site 103
S512
T
S
H
E
A
I
L
S
N
T
K
V
L
E
I
Site 104
S526
I
P
L
L
P
E
N
S
M
R
A
V
I
D
C
Site 105
S542
G
I
L
K
L
R
N
S
D
I
E
L
R
K
G
Site 106
T558
T
D
I
G
R
K
N
T
R
V
R
L
V
F
R
Site 107
S572
R
V
H
V
P
Q
P
S
G
R
T
L
S
L
Q
Site 108
S577
Q
P
S
G
R
T
L
S
L
Q
V
A
S
N
P
Site 109
S582
T
L
S
L
Q
V
A
S
N
P
I
E
C
S
Q
Site 110
S588
A
S
N
P
I
E
C
S
Q
R
S
A
Q
E
L
Site 111
S591
P
I
E
C
S
Q
R
S
A
Q
E
L
P
L
V
Site 112
S602
L
P
L
V
E
K
Q
S
T
D
S
Y
P
V
V
Site 113
T603
P
L
V
E
K
Q
S
T
D
S
Y
P
V
V
G
Site 114
S605
V
E
K
Q
S
T
D
S
Y
P
V
V
G
G
K
Site 115
Y606
E
K
Q
S
T
D
S
Y
P
V
V
G
G
K
K
Site 116
S617
G
G
K
K
M
V
L
S
G
H
N
F
L
Q
D
Site 117
S625
G
H
N
F
L
Q
D
S
K
V
I
F
V
E
K
Site 118
T646
V
W
E
M
E
A
K
T
D
R
D
L
C
K
P
Site 119
S655
R
D
L
C
K
P
N
S
L
V
V
E
I
P
P
Site 120
T669
P
F
R
N
Q
R
I
T
S
P
V
H
V
S
F
Site 121
S670
F
R
N
Q
R
I
T
S
P
V
H
V
S
F
Y
Site 122
Y677
S
P
V
H
V
S
F
Y
V
C
N
G
K
R
K
Site 123
S686
C
N
G
K
R
K
R
S
Q
Y
Q
R
F
T
Y
Site 124
Y688
G
K
R
K
R
S
Q
Y
Q
R
F
T
Y
L
P
Site 125
T692
R
S
Q
Y
Q
R
F
T
Y
L
P
A
N
V
P
Site 126
Y693
S
Q
Y
Q
R
F
T
Y
L
P
A
N
V
P
I
Site 127
T706
P
I
I
K
T
E
P
T
D
D
Y
E
P
A
P
Site 128
Y709
K
T
E
P
T
D
D
Y
E
P
A
P
T
C
G
Site 129
T714
D
D
Y
E
P
A
P
T
C
G
P
V
S
Q
G
Site 130
S723
G
P
V
S
Q
G
L
S
P
L
P
R
P
Y
Y
Site 131
Y729
L
S
P
L
P
R
P
Y
Y
S
Q
Q
L
A
M
Site 132
Y730
S
P
L
P
R
P
Y
Y
S
Q
Q
L
A
M
P
Site 133
S731
P
L
P
R
P
Y
Y
S
Q
Q
L
A
M
P
P
Site 134
T756
P
P
C
P
Q
R
S
T
L
M
P
A
A
P
G
Site 135
S765
M
P
A
A
P
G
V
S
P
K
L
H
D
L
S
Site 136
S772
S
P
K
L
H
D
L
S
P
A
A
Y
T
K
G
Site 137
Y776
H
D
L
S
P
A
A
Y
T
K
G
V
A
S
P
Site 138
S782
A
Y
T
K
G
V
A
S
P
G
H
C
H
L
G
Site 139
T809
D
V
P
R
P
V
A
T
H
P
G
S
P
G
Q
Site 140
S813
P
V
A
T
H
P
G
S
P
G
Q
P
P
P
A
Site 141
S827
A
L
L
P
Q
Q
V
S
A
P
P
S
S
S
C
Site 142
S831
Q
Q
V
S
A
P
P
S
S
S
C
P
P
G
L
Site 143
S832
Q
V
S
A
P
P
S
S
S
C
P
P
G
L
E
Site 144
S833
V
S
A
P
P
S
S
S
C
P
P
G
L
E
H
Site 145
S841
C
P
P
G
L
E
H
S
L
C
P
S
S
P
S
Site 146
S845
L
E
H
S
L
C
P
S
S
P
S
P
P
L
P
Site 147
S846
E
H
S
L
C
P
S
S
P
S
P
P
L
P
P
Site 148
S848
S
L
C
P
S
S
P
S
P
P
L
P
P
A
T
Site 149
T855
S
P
P
L
P
P
A
T
Q
E
P
T
C
L
Q
Site 150
S865
P
T
C
L
Q
P
C
S
P
A
C
P
P
A
T
Site 151
T872
S
P
A
C
P
P
A
T
G
R
P
Q
H
L
P
Site 152
S880
G
R
P
Q
H
L
P
S
T
V
R
R
D
E
S
Site 153
T881
R
P
Q
H
L
P
S
T
V
R
R
D
E
S
P
Site 154
S887
S
T
V
R
R
D
E
S
P
T
A
G
P
R
L
Site 155
T889
V
R
R
D
E
S
P
T
A
G
P
R
L
L
P
Site 156
S903
P
E
V
H
E
D
G
S
P
N
L
A
P
I
P
Site 157
T912
N
L
A
P
I
P
V
T
V
K
R
E
P
E
E
Site 158
Y924
P
E
E
L
D
Q
L
Y
L
D
D
V
N
E
I
Site 159
S937
E
I
I
R
N
D
L
S
S
T
S
T
H
S
_
Site 160
S938
I
I
R
N
D
L
S
S
T
S
T
H
S
_
_
Site 161
T939
I
R
N
D
L
S
S
T
S
T
H
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation