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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASMTL
Full Name:
N-acetylserotonin O-methyltransferase-like protein
Alias:
acetylserotonin N-methyltransferase-like; acetylserotonin O-methyltransferase-like; ASML; ASMTLX; ASMTLY; N-acetylserotonin O-methyltransferase-like
Type:
Methyltransferase
Mass (Da):
68857
Number AA:
621
UniProt ID:
O95671
International Prot ID:
IPI00479385
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0017096
PhosphoSite+
KinaseNET
Biological Process:
GO:0030187
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
H
K
R
V
V
L
A
S
A
S
P
R
R
Q
E
Site 2
S21
R
V
V
L
A
S
A
S
P
R
R
Q
E
I
L
Site 3
S29
P
R
R
Q
E
I
L
S
N
A
G
L
R
F
E
Site 4
S40
L
R
F
E
V
V
P
S
K
F
K
E
K
L
D
Site 5
S50
K
E
K
L
D
K
A
S
F
A
T
P
Y
G
Y
Site 6
T53
L
D
K
A
S
F
A
T
P
Y
G
Y
A
M
E
Site 7
Y55
K
A
S
F
A
T
P
Y
G
Y
A
M
E
T
A
Site 8
Y57
S
F
A
T
P
Y
G
Y
A
M
E
T
A
K
Q
Site 9
Y74
L
E
V
A
N
R
L
Y
Q
K
D
L
R
A
P
Site 10
Y108
P
V
D
K
Q
D
A
Y
R
M
L
S
R
L
S
Site 11
S112
Q
D
A
Y
R
M
L
S
R
L
S
G
R
E
H
Site 12
S115
Y
R
M
L
S
R
L
S
G
R
E
H
S
V
F
Site 13
T139
S
K
D
H
Q
L
D
T
R
V
S
E
F
Y
E
Site 14
S142
H
Q
L
D
T
R
V
S
E
F
Y
E
E
T
K
Site 15
Y145
D
T
R
V
S
E
F
Y
E
E
T
K
V
K
F
Site 16
Y163
S
E
E
L
L
W
E
Y
V
H
S
G
E
P
M
Site 17
S166
L
L
W
E
Y
V
H
S
G
E
P
M
D
K
A
Site 18
Y212
C
K
Q
L
V
K
L
Y
Y
P
P
R
P
E
D
Site 19
Y213
K
Q
L
V
K
L
Y
Y
P
P
R
P
E
D
L
Site 20
S223
R
P
E
D
L
R
R
S
V
K
H
D
S
I
P
Site 21
S228
R
R
S
V
K
H
D
S
I
P
A
A
D
T
F
Site 22
T234
D
S
I
P
A
A
D
T
F
E
D
L
S
D
V
Site 23
S239
A
D
T
F
E
D
L
S
D
V
E
G
G
G
S
Site 24
S246
S
D
V
E
G
G
G
S
E
P
T
Q
R
D
A
Site 25
T249
E
G
G
G
S
E
P
T
Q
R
D
A
G
S
R
Site 26
S255
P
T
Q
R
D
A
G
S
R
D
E
K
A
E
A
Site 27
T277
A
E
A
E
C
H
R
T
R
E
T
L
P
P
F
Site 28
T280
E
C
H
R
T
R
E
T
L
P
P
F
P
T
R
Site 29
S326
Q
K
A
A
D
I
A
S
K
V
D
A
S
A
C
Site 30
T351
A
M
G
L
L
E
K
T
E
Q
G
Y
S
N
T
Site 31
S356
E
K
T
E
Q
G
Y
S
N
T
E
T
A
N
V
Site 32
T360
Q
G
Y
S
N
T
E
T
A
N
V
Y
L
A
S
Site 33
Y364
N
T
E
T
A
N
V
Y
L
A
S
D
G
E
Y
Site 34
S367
T
A
N
V
Y
L
A
S
D
G
E
Y
S
L
H
Site 35
S372
L
A
S
D
G
E
Y
S
L
H
G
F
I
M
H
Site 36
T399
E
F
A
I
R
E
G
T
N
Q
H
H
R
A
L
Site 37
Y418
E
D
L
F
Q
D
A
Y
Y
Q
S
P
E
T
R
Site 38
Y419
D
L
F
Q
D
A
Y
Y
Q
S
P
E
T
R
L
Site 39
S421
F
Q
D
A
Y
Y
Q
S
P
E
T
R
L
R
F
Site 40
T424
A
Y
Y
Q
S
P
E
T
R
L
R
F
M
R
A
Site 41
Y473
A
R
E
L
A
R
E
Y
P
R
M
Q
V
T
V
Site 42
T479
E
Y
P
R
M
Q
V
T
V
F
D
L
P
D
I
Site 43
S517
F
F
R
D
P
L
P
S
A
E
L
Y
V
L
C
Site 44
S540
D
K
V
H
K
L
L
S
R
V
A
E
S
C
K
Site 45
S573
A
Q
R
A
L
M
Q
S
L
N
M
L
V
Q
T
Site 46
T580
S
L
N
M
L
V
Q
T
E
G
K
E
R
S
L
Site 47
Y590
K
E
R
S
L
G
E
Y
Q
C
L
L
E
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation