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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ECEL1
Full Name:
Endothelin-converting enzyme-like 1
Alias:
Damage induced neuronal endopeptidase; DINE; EC 3.4.24.-; ECEL; Endothelin converting enzyme-like 1; XCE; Xce protein
Type:
EC 3.4.24.-; Protease
Mass (Da):
87791
Number AA:
775
UniProt ID:
O95672
International Prot ID:
IPI00006735
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
P
Y
S
L
T
A
H
Y
D
E
F
Q
E
V
K
Site 2
Y19
D
E
F
Q
E
V
K
Y
V
S
R
C
G
A
G
Site 3
S21
F
Q
E
V
K
Y
V
S
R
C
G
A
G
G
A
Site 4
S44
F
P
L
G
A
A
R
S
A
T
G
A
R
S
G
Site 5
T46
L
G
A
A
R
S
A
T
G
A
R
S
G
L
P
Site 6
S50
R
S
A
T
G
A
R
S
G
L
P
R
W
N
R
Site 7
S186
K
V
R
A
F
F
R
S
C
L
D
M
R
E
I
Site 8
Y233
W
D
L
N
R
L
L
Y
K
A
Q
G
V
Y
S
Site 9
Y239
L
Y
K
A
Q
G
V
Y
S
A
A
A
L
F
S
Site 10
S250
A
L
F
S
L
T
V
S
L
D
D
R
N
S
S
Site 11
S256
V
S
L
D
D
R
N
S
S
R
Y
V
I
R
I
Site 12
S257
S
L
D
D
R
N
S
S
R
Y
V
I
R
I
D
Site 13
Y259
D
D
R
N
S
S
R
Y
V
I
R
I
D
Q
D
Site 14
T269
R
I
D
Q
D
G
L
T
L
P
E
R
T
L
Y
Site 15
Y276
T
L
P
E
R
T
L
Y
L
A
Q
D
E
D
S
Site 16
S283
Y
L
A
Q
D
E
D
S
E
K
I
L
A
A
Y
Site 17
S326
Q
L
A
N
I
T
V
S
E
H
D
D
L
R
R
Site 18
S336
D
D
L
R
R
D
V
S
S
M
Y
N
K
V
T
Site 19
S337
D
L
R
R
D
V
S
S
M
Y
N
K
V
T
L
Site 20
Y339
R
R
D
V
S
S
M
Y
N
K
V
T
L
G
Q
Site 21
T351
L
G
Q
L
Q
K
I
T
P
H
L
R
W
K
W
Site 22
S369
Q
I
F
Q
E
D
F
S
E
E
E
E
V
V
L
Site 23
S386
T
D
Y
M
Q
Q
V
S
Q
L
I
R
S
T
P
Site 24
T392
V
S
Q
L
I
R
S
T
P
H
R
V
L
H
N
Site 25
S431
L
A
Q
E
M
E
G
S
D
K
P
Q
E
L
A
Site 26
Y479
Q
L
V
E
D
I
K
Y
I
L
G
Q
R
L
E
Site 27
Y505
A
A
R
A
K
L
Q
Y
M
M
V
M
V
G
Y
Site 28
Y512
Y
M
M
V
M
V
G
Y
P
D
F
L
L
K
P
Site 29
Y526
P
D
A
V
D
K
E
Y
E
F
E
V
H
E
K
Site 30
Y535
F
E
V
H
E
K
T
Y
F
K
N
I
L
N
S
Site 31
S550
I
R
F
S
I
Q
L
S
V
K
K
I
R
Q
E
Site 32
S561
I
R
Q
E
V
D
K
S
T
W
L
L
P
P
Q
Site 33
Y573
P
P
Q
A
L
N
A
Y
Y
L
P
N
K
N
Q
Site 34
Y574
P
Q
A
L
N
A
Y
Y
L
P
N
K
N
Q
M
Site 35
Y593
G
I
L
Q
P
T
L
Y
D
P
D
F
P
Q
S
Site 36
S600
Y
D
P
D
F
P
Q
S
L
N
Y
G
G
I
G
Site 37
Y618
G
H
E
L
T
H
G
Y
D
D
W
G
G
Q
Y
Site 38
Y625
Y
D
D
W
G
G
Q
Y
D
R
S
G
N
L
L
Site 39
Y660
L
Y
D
N
F
T
V
Y
N
Q
R
V
N
G
K
Site 40
Y684
M
G
G
L
K
L
A
Y
H
A
Y
Q
K
W
V
Site 41
Y687
L
K
L
A
Y
H
A
Y
Q
K
W
V
R
E
H
Site 42
Y705
H
P
L
P
R
L
K
Y
T
H
D
Q
L
F
F
Site 43
S727
C
I
K
R
R
S
Q
S
I
Y
L
Q
V
L
T
Site 44
Y729
K
R
R
S
Q
S
I
Y
L
Q
V
L
T
D
K
Site 45
T734
S
I
Y
L
Q
V
L
T
D
K
H
A
P
E
H
Site 46
S747
E
H
Y
R
V
L
G
S
V
S
Q
F
E
E
F
Site 47
S749
Y
R
V
L
G
S
V
S
Q
F
E
E
F
G
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation