KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KRT75
Full Name:
Keratin, type II cytoskeletal 75
Alias:
Cytokeratin-75; HK6hf; K6HF; KB18; Keratin 75; Keratin-6 hair follicle; Keratin-75; Type II keratin-18; Type II keratin-K6hf
Type:
Cytoskeletal protein
Mass (Da):
59560
Number AA:
551
UniProt ID:
O95678
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045095
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
R
Q
S
S
I
T
F
Q
S
G
Site 2
S6
_
_
M
S
R
Q
S
S
I
T
F
Q
S
G
S
Site 3
T8
M
S
R
Q
S
S
I
T
F
Q
S
G
S
R
R
Site 4
S11
Q
S
S
I
T
F
Q
S
G
S
R
R
G
F
S
Site 5
S13
S
I
T
F
Q
S
G
S
R
R
G
F
S
T
T
Site 6
S18
S
G
S
R
R
G
F
S
T
T
S
A
I
T
P
Site 7
T19
G
S
R
R
G
F
S
T
T
S
A
I
T
P
A
Site 8
T20
S
R
R
G
F
S
T
T
S
A
I
T
P
A
A
Site 9
S21
R
R
G
F
S
T
T
S
A
I
T
P
A
A
G
Site 10
T24
F
S
T
T
S
A
I
T
P
A
A
G
R
S
R
Site 11
S33
A
A
G
R
S
R
F
S
S
V
S
V
A
R
S
Site 12
S34
A
G
R
S
R
F
S
S
V
S
V
A
R
S
A
Site 13
S36
R
S
R
F
S
S
V
S
V
A
R
S
A
A
G
Site 14
S56
R
I
S
S
A
G
A
S
F
G
S
R
S
L
Y
Site 15
S59
S
A
G
A
S
F
G
S
R
S
L
Y
N
L
G
Site 16
S61
G
A
S
F
G
S
R
S
L
Y
N
L
G
G
A
Site 17
Y63
S
F
G
S
R
S
L
Y
N
L
G
G
A
K
R
Site 18
S72
L
G
G
A
K
R
V
S
I
N
G
C
G
S
S
Site 19
S78
V
S
I
N
G
C
G
S
S
C
R
S
G
F
G
Site 20
S79
S
I
N
G
C
G
S
S
C
R
S
G
F
G
G
Site 21
S82
G
C
G
S
S
C
R
S
G
F
G
G
R
A
S
Site 22
S89
S
G
F
G
G
R
A
S
N
R
F
G
V
N
S
Site 23
S96
S
N
R
F
G
V
N
S
G
F
G
Y
G
G
G
Site 24
T132
T
V
N
Q
S
L
L
T
P
L
H
L
Q
I
D
Site 25
T141
L
H
L
Q
I
D
P
T
I
Q
R
V
R
A
E
Site 26
T155
E
E
R
E
Q
I
K
T
L
N
N
K
F
A
S
Site 27
S162
T
L
N
N
K
F
A
S
F
I
D
K
V
R
F
Site 28
T191
L
Q
E
Q
G
S
R
T
V
R
Q
N
L
E
P
Site 29
S202
N
L
E
P
L
F
D
S
Y
T
S
E
L
R
R
Site 30
Y203
L
E
P
L
F
D
S
Y
T
S
E
L
R
R
Q
Site 31
T204
E
P
L
F
D
S
Y
T
S
E
L
R
R
Q
L
Site 32
S213
E
L
R
R
Q
L
E
S
I
T
T
E
R
G
R
Site 33
T216
R
Q
L
E
S
I
T
T
E
R
G
R
L
E
A
Site 34
Y239
V
E
D
F
K
V
R
Y
E
D
E
I
N
K
R
Site 35
Y264
K
K
D
V
D
A
A
Y
M
N
K
V
E
L
E
Site 36
S276
E
L
E
A
K
V
K
S
L
P
E
E
I
N
F
Site 37
S293
S
V
F
D
A
E
L
S
Q
L
Q
T
Q
V
G
Site 38
T297
A
E
L
S
Q
L
Q
T
Q
V
G
D
T
S
V
Site 39
T302
L
Q
T
Q
V
G
D
T
S
V
V
L
S
M
D
Site 40
S303
Q
T
Q
V
G
D
T
S
V
V
L
S
M
D
N
Site 41
S307
G
D
T
S
V
V
L
S
M
D
N
N
R
N
L
Site 42
S318
N
R
N
L
D
L
D
S
I
I
A
E
V
K
A
Site 43
Y327
I
A
E
V
K
A
Q
Y
E
D
I
A
N
R
S
Site 44
S334
Y
E
D
I
A
N
R
S
R
A
E
A
E
S
W
Site 45
S340
R
S
R
A
E
A
E
S
W
Y
Q
T
K
Y
E
Site 46
Y342
R
A
E
A
E
S
W
Y
Q
T
K
Y
E
E
L
Site 47
T344
E
A
E
S
W
Y
Q
T
K
Y
E
E
L
Q
V
Site 48
Y346
E
S
W
Y
Q
T
K
Y
E
E
L
Q
V
T
A
Site 49
T352
K
Y
E
E
L
Q
V
T
A
G
R
H
G
D
D
Site 50
T363
H
G
D
D
L
R
N
T
K
Q
E
I
S
E
M
Site 51
S383
R
L
R
A
E
I
D
S
V
K
K
Q
C
S
S
Site 52
S390
S
V
K
K
Q
C
S
S
L
Q
T
A
I
A
D
Site 53
Y434
M
A
R
L
L
R
E
Y
Q
E
L
M
N
I
K
Site 54
Y451
L
D
V
E
I
A
T
Y
R
K
L
L
E
G
E
Site 55
S463
E
G
E
E
C
R
L
S
G
E
G
V
S
P
V
Site 56
S480
S
V
V
T
S
T
L
S
S
G
Y
G
S
G
S
Site 57
S481
V
V
T
S
T
L
S
S
G
Y
G
S
G
S
S
Site 58
Y483
T
S
T
L
S
S
G
Y
G
S
G
S
S
I
G
Site 59
S485
T
L
S
S
G
Y
G
S
G
S
S
I
G
G
G
Site 60
S487
S
S
G
Y
G
S
G
S
S
I
G
G
G
N
L
Site 61
S488
S
G
Y
G
S
G
S
S
I
G
G
G
N
L
G
Site 62
S500
N
L
G
L
G
G
G
S
G
Y
S
F
T
T
S
Site 63
Y502
G
L
G
G
G
S
G
Y
S
F
T
T
S
G
G
Site 64
S503
L
G
G
G
S
G
Y
S
F
T
T
S
G
G
H
Site 65
T505
G
G
S
G
Y
S
F
T
T
S
G
G
H
S
L
Site 66
S507
S
G
Y
S
F
T
T
S
G
G
H
S
L
G
A
Site 67
T524
G
G
S
G
F
S
A
T
S
N
R
G
L
G
G
Site 68
S525
G
S
G
F
S
A
T
S
N
R
G
L
G
G
S
Site 69
S532
S
N
R
G
L
G
G
S
G
S
S
V
K
F
V
Site 70
S534
R
G
L
G
G
S
G
S
S
V
K
F
V
S
T
Site 71
S535
G
L
G
G
S
G
S
S
V
K
F
V
S
T
T
Site 72
S540
G
S
S
V
K
F
V
S
T
T
S
S
S
Q
K
Site 73
T541
S
S
V
K
F
V
S
T
T
S
S
S
Q
K
S
Site 74
T542
S
V
K
F
V
S
T
T
S
S
S
Q
K
S
Y
Site 75
S543
V
K
F
V
S
T
T
S
S
S
Q
K
S
Y
T
Site 76
S544
K
F
V
S
T
T
S
S
S
Q
K
S
Y
T
H
Site 77
S545
F
V
S
T
T
S
S
S
Q
K
S
Y
T
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation