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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HERC2
Full Name:
E3 ubiquitin-protein ligase HERC2
Alias:
D15F37S1; HECT domain and RCC1-like domain-containing 2; HECT domain and RCC1-like domain-containing protein 2; Hect domain and RLD 2; Jdf2; P528
Type:
EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase; Ligase
Mass (Da):
527472
Number AA:
4834
UniProt ID:
O95714
International Prot ID:
IPI00005826
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0020037
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0019941
GO:0016567
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
A
Q
A
R
L
D
S
K
W
L
K
T
D
I
Site 2
Y47
V
K
D
G
E
I
V
Y
T
G
T
E
S
T
Q
Site 3
T48
K
D
G
E
I
V
Y
T
G
T
E
S
T
Q
N
Site 4
S65
L
P
P
R
K
D
D
S
V
E
P
S
G
T
K
Site 5
S69
K
D
D
S
V
E
P
S
G
T
K
K
E
D
L
Site 6
T71
D
S
V
E
P
S
G
T
K
K
E
D
L
N
D
Site 7
T87
E
K
K
D
E
E
E
T
P
A
P
I
Y
R
A
Site 8
Y92
E
E
T
P
A
P
I
Y
R
A
K
S
I
L
D
Site 9
S100
R
A
K
S
I
L
D
S
W
V
W
G
K
Q
P
Site 10
S117
N
E
L
K
E
C
L
S
V
L
V
K
E
Q
Q
Site 11
S136
Q
S
A
T
T
T
L
S
A
L
R
L
K
Q
R
Site 12
T157
Y
F
I
A
L
N
R
T
V
F
Q
E
N
V
K
Site 13
S169
N
V
K
V
K
W
K
S
S
G
I
S
L
P
P
Site 14
S173
K
W
K
S
S
G
I
S
L
P
P
V
D
K
K
Site 15
S181
L
P
P
V
D
K
K
S
S
R
P
A
G
K
G
Site 16
S182
P
P
V
D
K
K
S
S
R
P
A
G
K
G
V
Site 17
S214
F
L
R
R
A
W
R
S
G
E
D
A
D
L
C
Site 18
S222
G
E
D
A
D
L
C
S
E
L
L
Q
E
S
L
Site 19
S263
R
A
T
R
F
L
R
S
V
V
T
G
D
V
H
Site 20
T272
V
T
G
D
V
H
G
T
P
A
T
K
G
P
G
Site 21
T275
D
V
H
G
T
P
A
T
K
G
P
G
S
I
P
Site 22
S280
P
A
T
K
G
P
G
S
I
P
L
Q
D
Q
H
Site 23
S319
L
L
L
Q
L
W
D
S
G
A
Q
E
T
D
N
Site 24
T333
N
E
R
S
A
Q
G
T
S
A
P
L
L
P
L
Site 25
S346
P
L
L
Q
R
F
Q
S
I
I
C
R
K
D
A
Site 26
S356
C
R
K
D
A
P
H
S
E
G
D
M
H
L
L
Site 27
S364
E
G
D
M
H
L
L
S
G
P
L
S
P
N
E
Site 28
S368
H
L
L
S
G
P
L
S
P
N
E
S
F
L
R
Site 29
S372
G
P
L
S
P
N
E
S
F
L
R
Y
L
T
L
Site 30
Y376
P
N
E
S
F
L
R
Y
L
T
L
P
Q
D
N
Site 31
T378
E
S
F
L
R
Y
L
T
L
P
Q
D
N
E
L
Site 32
T405
A
H
L
D
R
L
A
T
P
C
M
P
P
L
C
Site 33
S413
P
C
M
P
P
L
C
S
S
P
T
S
H
K
G
Site 34
S414
C
M
P
P
L
C
S
S
P
T
S
H
K
G
S
Site 35
T416
P
P
L
C
S
S
P
T
S
H
K
G
S
L
Q
Site 36
S417
P
L
C
S
S
P
T
S
H
K
G
S
L
Q
E
Site 37
S421
S
P
T
S
H
K
G
S
L
Q
E
V
I
G
W
Site 38
S467
E
K
R
F
L
I
L
S
R
N
G
R
V
Y
T
Site 39
Y473
L
S
R
N
G
R
V
Y
T
Q
A
Y
N
S
D
Site 40
T474
S
R
N
G
R
V
Y
T
Q
A
Y
N
S
D
T
Site 41
Y477
G
R
V
Y
T
Q
A
Y
N
S
D
T
L
A
P
Site 42
T481
T
Q
A
Y
N
S
D
T
L
A
P
Q
L
V
Q
Site 43
S518
A
A
T
G
E
V
Y
S
W
G
C
G
D
G
G
Site 44
T532
G
R
L
G
H
G
D
T
V
P
L
E
E
P
K
Site 45
T567
S
T
Y
S
A
A
I
T
A
E
G
E
L
Y
T
Site 46
Y573
I
T
A
E
G
E
L
Y
T
W
G
R
G
N
Y
Site 47
Y580
Y
T
W
G
R
G
N
Y
G
R
L
G
H
G
S
Site 48
S587
Y
G
R
L
G
H
G
S
S
E
D
E
A
I
P
Site 49
S588
G
R
L
G
H
G
S
S
E
D
E
A
I
P
M
Site 50
T617
C
G
S
G
D
A
Q
T
L
A
V
T
E
N
G
Site 51
Y634
W
S
W
G
D
G
D
Y
G
K
L
G
R
G
G
Site 52
S642
G
K
L
G
R
G
G
S
D
G
C
K
T
P
K
Site 53
T647
G
G
S
D
G
C
K
T
P
K
L
I
E
K
L
Site 54
T673
S
Q
F
S
I
A
L
T
K
D
G
Q
V
Y
S
Site 55
Y679
L
T
K
D
G
Q
V
Y
S
W
G
K
G
D
N
Site 56
S680
T
K
D
G
Q
V
Y
S
W
G
K
G
D
N
Q
Site 57
T693
N
Q
R
L
G
H
G
T
E
E
H
V
R
Y
P
Site 58
Y699
G
T
E
E
H
V
R
Y
P
K
L
L
E
G
L
Site 59
T725
S
T
H
C
L
A
L
T
E
D
S
E
V
H
S
Site 60
S728
C
L
A
L
T
E
D
S
E
V
H
S
W
G
S
Site 61
S732
T
E
D
S
E
V
H
S
W
G
S
N
D
Q
C
Site 62
T744
D
Q
C
Q
H
F
D
T
L
R
V
T
K
P
E
Site 63
T748
H
F
D
T
L
R
V
T
K
P
E
P
A
A
L
Site 64
S777
P
A
Q
S
F
A
W
S
S
C
S
E
W
S
I
Site 65
S778
A
Q
S
F
A
W
S
S
C
S
E
W
S
I
G
Site 66
S780
S
F
A
W
S
S
C
S
E
W
S
I
G
L
R
Site 67
S810
D
L
L
L
R
Q
V
S
E
G
M
D
G
S
A
Site 68
S816
V
S
E
G
M
D
G
S
A
D
W
P
P
P
Q
Site 69
S845
L
Q
L
H
A
A
I
S
H
Q
V
D
P
E
F
Site 70
S924
S
G
N
E
V
N
I
S
P
G
R
R
F
M
I
Site 71
S979
D
E
Q
E
A
N
A
S
T
F
H
R
S
R
T
Site 72
T980
E
Q
E
A
N
A
S
T
F
H
R
S
R
T
P
Site 73
T986
S
T
F
H
R
S
R
T
P
L
D
K
D
L
I
Site 74
S1021
Q
L
L
R
N
I
A
S
Q
T
V
A
R
L
K
Site 75
T1023
L
R
N
I
A
S
Q
T
V
A
R
L
K
D
V
Site 76
S1035
K
D
V
A
R
R
I
S
S
C
L
D
F
E
Q
Site 77
S1036
D
V
A
R
R
I
S
S
C
L
D
F
E
Q
H
Site 78
S1044
C
L
D
F
E
Q
H
S
R
E
R
S
A
S
L
Site 79
S1048
E
Q
H
S
R
E
R
S
A
S
L
D
W
L
L
Site 80
S1050
H
S
R
E
R
S
A
S
L
D
W
L
L
R
F
Site 81
Y1066
R
L
L
I
S
K
L
Y
P
G
E
S
I
G
Q
Site 82
S1070
S
K
L
Y
P
G
E
S
I
G
Q
T
S
D
I
Site 83
T1074
P
G
E
S
I
G
Q
T
S
D
I
S
S
P
E
Site 84
S1075
G
E
S
I
G
Q
T
S
D
I
S
S
P
E
L
Site 85
S1078
I
G
Q
T
S
D
I
S
S
P
E
L
M
G
V
Site 86
S1079
G
Q
T
S
D
I
S
S
P
E
L
M
G
V
G
Site 87
T1240
Y
D
I
K
D
F
Q
T
Q
S
L
T
G
N
S
Site 88
S1242
I
K
D
F
Q
T
Q
S
L
T
G
N
S
I
L
Site 89
T1244
D
F
Q
T
Q
S
L
T
G
N
S
I
L
A
Q
Site 90
T1270
A
A
L
Q
F
E
D
T
R
E
S
M
H
A
F
Site 91
Y1282
H
A
F
C
V
G
Q
Y
L
E
P
D
Q
E
I
Site 92
T1291
E
P
D
Q
E
I
V
T
I
P
D
L
G
S
L
Site 93
S1300
P
D
L
G
S
L
S
S
P
L
I
D
T
E
R
Site 94
S1343
W
L
Q
S
S
I
F
S
G
G
L
Q
T
S
Q
Site 95
Y1353
L
Q
T
S
Q
I
H
Y
R
Y
N
E
E
K
D
Site 96
S1365
E
K
D
E
D
H
C
S
S
P
G
G
T
P
A
Site 97
S1366
K
D
E
D
H
C
S
S
P
G
G
T
P
A
S
Site 98
T1370
H
C
S
S
P
G
G
T
P
A
S
K
S
R
L
Site 99
S1373
S
P
G
G
T
P
A
S
K
S
R
L
C
S
H
Site 100
S1375
G
G
T
P
A
S
K
S
R
L
C
S
H
R
R
Site 101
S1379
A
S
K
S
R
L
C
S
H
R
R
A
L
G
D
Site 102
S1388
R
R
A
L
G
D
H
S
Q
A
F
L
Q
A
I
Site 103
T1472
I
E
Q
V
K
H
R
T
L
P
K
S
V
V
D
Site 104
S1476
K
H
R
T
L
P
K
S
V
V
D
V
C
R
V
Site 105
T1494
A
K
C
S
L
I
K
T
H
Q
E
Q
G
R
S
Site 106
Y1502
H
Q
E
Q
G
R
S
Y
K
E
V
C
A
P
V
Site 107
S1538
M
S
K
F
K
L
L
S
S
L
P
R
W
R
R
Site 108
S1539
S
K
F
K
L
L
S
S
L
P
R
W
R
R
I
Site 109
S1565
R
V
P
K
K
P
E
S
M
D
D
E
E
K
I
Site 110
S1577
E
K
I
G
N
E
E
S
D
L
E
E
A
C
I
Site 111
S1588
E
A
C
I
L
P
H
S
P
I
N
V
D
K
R
Site 112
S1601
K
R
P
I
A
I
K
S
P
K
D
K
W
Q
P
Site 113
S1611
D
K
W
Q
P
L
L
S
T
V
T
G
V
H
K
Site 114
T1612
K
W
Q
P
L
L
S
T
V
T
G
V
H
K
Y
Site 115
Y1630
K
Q
N
V
Q
G
L
Y
P
Q
S
P
L
L
S
Site 116
T1711
I
D
I
G
E
P
L
T
D
C
L
K
D
V
D
Site 117
S1773
T
I
T
N
E
N
P
S
G
P
S
L
G
T
I
Site 118
S1791
R
F
L
L
V
M
L
S
M
L
T
L
Q
H
G
Site 119
T1814
N
S
G
M
L
A
L
T
Q
T
A
L
R
L
I
Site 120
S1824
A
L
R
L
I
G
P
S
C
D
N
V
E
E
D
Site 121
T1842
S
A
Q
G
A
S
A
T
V
L
E
E
T
R
K
Site 122
T1851
L
E
E
T
R
K
E
T
A
P
V
Q
L
P
V
Site 123
S1915
W
D
T
G
S
T
N
S
Y
R
M
G
K
E
G
Site 124
Y1916
D
T
G
S
T
N
S
Y
R
M
G
K
E
G
K
Site 125
Y1924
R
M
G
K
E
G
K
Y
D
L
K
L
A
E
L
Site 126
S1938
L
P
A
A
A
Q
P
S
A
E
D
S
D
T
E
Site 127
S1942
A
Q
P
S
A
E
D
S
D
T
E
D
D
S
E
Site 128
T1944
P
S
A
E
D
S
D
T
E
D
D
S
E
A
E
Site 129
S1948
D
S
D
T
E
D
D
S
E
A
E
Q
T
E
R
Site 130
T1953
D
D
S
E
A
E
Q
T
E
R
N
I
H
P
T
Site 131
T1960
T
E
R
N
I
H
P
T
A
M
M
F
T
S
T
Site 132
S1987
V
H
A
E
I
M
Q
S
E
A
T
K
T
L
C
Site 133
S2003
L
L
R
M
L
V
E
S
G
T
T
D
K
T
S
Site 134
T2005
R
M
L
V
E
S
G
T
T
D
K
T
S
S
P
Site 135
T2006
M
L
V
E
S
G
T
T
D
K
T
S
S
P
N
Site 136
T2009
E
S
G
T
T
D
K
T
S
S
P
N
R
L
V
Site 137
S2010
S
G
T
T
D
K
T
S
S
P
N
R
L
V
Y
Site 138
S2011
G
T
T
D
K
T
S
S
P
N
R
L
V
Y
R
Site 139
Y2017
S
S
P
N
R
L
V
Y
R
E
Q
H
R
S
W
Site 140
T2087
V
L
P
S
W
D
K
T
E
R
A
R
D
M
K
Site 141
S2121
D
V
P
L
L
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I
N
Site 293
T3803
L
G
E
N
D
G
E
T
R
A
L
S
F
T
G
Site 294
S3807
D
G
E
T
R
A
L
S
F
T
G
S
A
L
A
Site 295
Y3830
A
L
Q
R
Q
F
E
Y
E
D
P
I
V
R
G
Site 296
T3945
N
R
R
P
D
D
W
T
L
S
A
G
G
S
G
Site 297
S3947
R
P
D
D
W
T
L
S
A
G
G
S
G
T
I
Site 298
S3951
W
T
L
S
A
G
G
S
G
T
I
Y
G
W
G
Site 299
T3953
L
S
A
G
G
S
G
T
I
Y
G
W
G
H
N
Site 300
Y3955
A
G
G
S
G
T
I
Y
G
W
G
H
N
H
R
Site 301
Y4007
V
T
A
D
G
K
L
Y
A
T
G
Y
G
A
G
Site 302
Y4011
G
K
L
Y
A
T
G
Y
G
A
G
G
R
L
G
Site 303
T4022
G
R
L
G
I
G
G
T
E
S
V
S
T
P
T
Site 304
S4026
I
G
G
T
E
S
V
S
T
P
T
L
L
E
S
Site 305
T4027
G
G
T
E
S
V
S
T
P
T
L
L
E
S
I
Site 306
S4055
G
K
H
C
L
A
L
S
S
E
G
E
V
Y
S
Site 307
S4056
K
H
C
L
A
L
S
S
E
G
E
V
Y
S
W
Site 308
Y4061
L
S
S
E
G
E
V
Y
S
W
G
E
A
E
D
Site 309
S4062
S
S
E
G
E
V
Y
S
W
G
E
A
E
D
G
Site 310
S4077
K
L
G
H
G
N
R
S
P
C
D
R
P
R
V
Site 311
S4087
D
R
P
R
V
I
E
S
L
R
G
I
E
V
V
Site 312
Y4113
V
T
A
A
G
D
L
Y
T
W
G
K
G
R
Y
Site 313
T4114
T
A
A
G
D
L
Y
T
W
G
K
G
R
Y
G
Site 314
Y4120
Y
T
W
G
K
G
R
Y
G
R
L
G
H
S
D
Site 315
S4126
R
Y
G
R
L
G
H
S
D
S
E
D
Q
L
K
Site 316
S4128
G
R
L
G
H
S
D
S
E
D
Q
L
K
P
K
Site 317
T4157
C
G
S
G
D
A
Q
T
L
C
L
T
D
D
D
Site 318
S4182
G
K
L
G
R
G
G
S
D
G
C
K
V
P
M
Site 319
Y4219
L
T
K
S
G
A
V
Y
T
W
G
K
G
D
Y
Site 320
Y4226
Y
T
W
G
K
G
D
Y
H
R
L
G
H
G
S
Site 321
S4233
Y
H
R
L
G
H
G
S
D
D
H
V
R
R
P
Site 322
T4285
E
G
Q
L
G
D
G
T
T
N
A
I
Q
R
P
Site 323
T4286
G
Q
L
G
D
G
T
T
N
A
I
Q
R
P
R
Site 324
S4317
S
A
H
T
L
A
W
S
T
S
K
P
A
S
A
Site 325
S4319
H
T
L
A
W
S
T
S
K
P
A
S
A
G
K
Site 326
S4323
W
S
T
S
K
P
A
S
A
G
K
L
P
A
Q
Site 327
S4372
P
M
F
D
L
E
G
S
L
D
E
T
G
L
G
Site 328
T4376
L
E
G
S
L
D
E
T
G
L
G
P
S
V
G
Site 329
S4381
D
E
T
G
L
G
P
S
V
G
F
D
T
L
R
Site 330
S4430
I
Q
V
K
R
S
R
S
K
G
G
L
A
G
P
Site 331
T4440
G
L
A
G
P
D
G
T
K
S
V
F
G
Q
M
Site 332
S4442
A
G
P
D
G
T
K
S
V
F
G
Q
M
C
A
Site 333
S4474
K
V
K
F
V
G
E
S
V
D
D
C
G
G
G
Site 334
S4483
D
D
C
G
G
G
Y
S
E
S
I
A
E
I
C
Site 335
S4485
C
G
G
G
Y
S
E
S
I
A
E
I
C
E
E
Site 336
T4504
L
T
P
L
L
I
V
T
P
N
G
R
D
E
S
Site 337
S4511
T
P
N
G
R
D
E
S
G
A
N
R
D
C
Y
Site 338
Y4518
S
G
A
N
R
D
C
Y
L
L
S
P
A
A
R
Site 339
S4521
N
R
D
C
Y
L
L
S
P
A
A
R
A
P
V
Site 340
Y4585
D
F
I
P
G
L
M
Y
I
R
D
N
E
A
T
Site 341
T4592
Y
I
R
D
N
E
A
T
S
E
E
F
E
A
M
Site 342
S4593
I
R
D
N
E
A
T
S
E
E
F
E
A
M
S
Site 343
S4600
S
E
E
F
E
A
M
S
L
P
F
T
V
P
S
Site 344
T4604
E
A
M
S
L
P
F
T
V
P
S
A
S
G
Q
Site 345
S4607
S
L
P
F
T
V
P
S
A
S
G
Q
D
I
Q
Site 346
S4609
P
F
T
V
P
S
A
S
G
Q
D
I
Q
L
S
Site 347
S4616
S
G
Q
D
I
Q
L
S
S
K
H
T
H
I
T
Site 348
Y4630
T
L
D
N
R
A
E
Y
V
R
L
A
I
N
Y
Site 349
S4687
I
P
L
H
L
L
K
S
V
A
T
Y
K
G
I
Site 350
T4690
H
L
L
K
S
V
A
T
Y
K
G
I
E
P
S
Site 351
S4697
T
Y
K
G
I
E
P
S
A
S
L
I
Q
W
F
Site 352
S4699
K
G
I
E
P
S
A
S
L
I
Q
W
F
W
E
Site 353
S4710
W
F
W
E
V
M
E
S
F
S
N
T
E
R
S
Site 354
T4714
V
M
E
S
F
S
N
T
E
R
S
L
F
L
R
Site 355
S4717
S
F
S
N
T
E
R
S
L
F
L
R
F
V
W
Site 356
T4732
G
R
T
R
L
P
R
T
I
A
D
F
R
G
R
Site 357
Y4749
V
I
Q
V
L
D
K
Y
N
P
P
D
H
F
L
Site 358
S4772
L
L
K
L
P
R
Y
S
C
K
Q
V
L
E
E
Site 359
Y4783
V
L
E
E
K
L
K
Y
A
I
H
F
C
K
S
Site 360
Y4796
K
S
I
D
T
D
D
Y
A
R
I
A
L
T
G
Site 361
T4802
D
Y
A
R
I
A
L
T
G
E
P
A
A
D
D
Site 362
S4810
G
E
P
A
A
D
D
S
S
D
D
S
D
N
E
Site 363
S4811
E
P
A
A
D
D
S
S
D
D
S
D
N
E
D
Site 364
S4814
A
D
D
S
S
D
D
S
D
N
E
D
V
D
S
Site 365
S4821
S
D
N
E
D
V
D
S
F
A
S
D
S
T
Q
Site 366
S4824
E
D
V
D
S
F
A
S
D
S
T
Q
D
Y
L
Site 367
S4826
V
D
S
F
A
S
D
S
T
Q
D
Y
L
T
G
Site 368
T4827
D
S
F
A
S
D
S
T
Q
D
Y
L
T
G
H
Site 369
Y4830
A
S
D
S
T
Q
D
Y
L
T
G
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation