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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSR1
Full Name:
Serine/threonine-protein kinase OSR1
Alias:
EC 2.7.11.1; OXSR1
Type:
Protein-serine kinase, STE group, STE20 family, FRAY subfamily
Mass (Da):
58022
Number AA:
527
UniProt ID:
O95747
International Prot ID:
IPI00152145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007243
GO:0006979
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase OSR1 T185 phosphosite-specific antibody AB-PK738#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK738#SLC12A2 (198-217) KinSub - SLC12A2-derived peptide substrate; CATCHtide protein kinase substrate peptide - Powder PE-01ADS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADS95#Serine/threonine-protein kinase OSR1 (V182-G188, human) pT185 phosphopeptide - Powder PE-04AOG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOG99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
S
S
A
L
P
W
S
I
N
R
D
D
Y
E
Site 2
Y17
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
Site 3
Y35
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
Site 4
T55
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
Site 5
S56
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
Site 6
Y78
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
Site 7
Y79
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
Site 8
S115
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
Site 9
Y136
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
Site 10
S168
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
Site 11
T173
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
Site 12
T185
T
R
N
K
V
R
K
T
F
V
G
T
P
C
W
Serine/threonine-protein kinase OSR1 T185 phosphosite-specific antibody AB-PK738#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK738#Serine/threonine-protein kinase OSR1 (V182-G188, human) pT185 phosphopeptide - Powder PE-04AOG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOG99
Site 13
T189
V
R
K
T
F
V
G
T
P
C
W
M
A
P
E
Site 14
Y204
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
Site 15
Y230
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
Site 16
T239
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
Site 17
S246
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
Site 18
Y260
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
Site 19
S263
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
Site 20
S269
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
Site 21
T281
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
Site 22
T304
K
E
F
L
Q
E
K
T
L
Q
R
A
P
T
I
Site 23
T310
K
T
L
Q
R
A
P
T
I
S
E
R
A
K
K
Site 24
S312
L
Q
R
A
P
T
I
S
E
R
A
K
K
V
R
Site 25
S324
K
V
R
R
V
P
G
S
S
G
R
L
H
K
T
Site 26
S325
V
R
R
V
P
G
S
S
G
R
L
H
K
T
E
Site 27
T331
S
S
G
R
L
H
K
T
E
D
G
G
W
E
W
Site 28
S339
E
D
G
G
W
E
W
S
D
D
E
F
D
E
E
Site 29
S347
D
D
E
F
D
E
E
S
E
E
G
K
A
A
I
Site 30
S355
E
E
G
K
A
A
I
S
Q
L
R
S
P
R
V
Site 31
S359
A
A
I
S
Q
L
R
S
P
R
V
K
E
S
I
Site 32
S365
R
S
P
R
V
K
E
S
I
S
N
S
E
L
F
Site 33
S367
P
R
V
K
E
S
I
S
N
S
E
L
F
P
T
Site 34
S369
V
K
E
S
I
S
N
S
E
L
F
P
T
T
D
Site 35
T374
S
N
S
E
L
F
P
T
T
D
P
V
G
T
L
Site 36
S407
A
T
Q
P
T
Q
V
S
L
P
P
T
A
E
P
Site 37
T411
T
Q
V
S
L
P
P
T
A
E
P
A
K
T
A
Site 38
T417
P
T
A
E
P
A
K
T
A
Q
A
L
S
S
G
Site 39
S422
A
K
T
A
Q
A
L
S
S
G
S
G
S
Q
E
Site 40
S423
K
T
A
Q
A
L
S
S
G
S
G
S
Q
E
T
Site 41
S425
A
Q
A
L
S
S
G
S
G
S
Q
E
T
K
I
Site 42
S427
A
L
S
S
G
S
G
S
Q
E
T
K
I
P
I
Site 43
T430
S
G
S
G
S
Q
E
T
K
I
P
I
S
L
V
Site 44
S435
Q
E
T
K
I
P
I
S
L
V
L
R
L
R
N
Site 45
S443
L
V
L
R
L
R
N
S
K
K
E
L
N
D
I
Site 46
T455
N
D
I
R
F
E
F
T
P
G
R
D
T
A
E
Site 47
T460
E
F
T
P
G
R
D
T
A
E
G
V
S
Q
E
Site 48
S465
R
D
T
A
E
G
V
S
Q
E
L
I
S
A
G
Site 49
S495
K
I
V
E
E
P
Q
S
N
R
S
V
T
F
K
Site 50
S498
E
E
P
Q
S
N
R
S
V
T
F
K
L
A
S
Site 51
T500
P
Q
S
N
R
S
V
T
F
K
L
A
S
G
V
Site 52
S510
L
A
S
G
V
E
G
S
D
I
P
D
D
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation