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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPA4L
Full Name:
Heat shock 70 kDa protein 4L
Alias:
APG1; APG-1; Heat shock 70kDa protein 4-like; Heat shock 70-related protein APG-1; Heat shock protein (hsp110 family); HS74L; Osmotic stress protein 94; OSP94
Type:
Chaperone protein
Mass (Da):
94486
Number AA:
839
UniProt ID:
O95757
International Prot ID:
IPI00032892
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0006986
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T35
N
E
Y
S
D
R
C
T
P
A
C
I
S
L
G
Site 2
S40
R
C
T
P
A
C
I
S
L
G
S
R
T
R
A
Site 3
T58
A
A
K
S
Q
I
V
T
N
V
R
N
T
I
H
Site 4
T63
I
V
T
N
V
R
N
T
I
H
G
F
K
K
L
Site 5
S74
F
K
K
L
H
G
R
S
F
D
D
P
I
V
Q
Site 6
T82
F
D
D
P
I
V
Q
T
E
R
I
R
L
P
Y
Site 7
Y89
T
E
R
I
R
L
P
Y
E
L
Q
K
M
P
N
Site 8
Y105
S
A
G
V
K
V
R
Y
L
E
E
E
R
P
F
Site 9
S155
F
T
D
A
E
R
R
S
V
M
A
A
A
Q
V
Site 10
T175
L
R
L
M
N
E
T
T
A
V
A
L
A
Y
G
Site 11
Y181
T
T
A
V
A
L
A
Y
G
I
Y
K
Q
D
L
Site 12
Y184
V
A
L
A
Y
G
I
Y
K
Q
D
L
P
P
L
Site 13
T225
G
K
L
K
V
L
A
T
T
F
D
P
Y
L
G
Site 14
Y230
L
A
T
T
F
D
P
Y
L
G
G
R
N
F
D
Site 15
Y243
F
D
E
A
L
V
D
Y
F
C
D
E
F
K
T
Site 16
Y252
C
D
E
F
K
T
K
Y
K
I
N
V
K
E
N
Site 17
Y267
S
R
A
L
L
R
L
Y
Q
E
C
E
K
L
K
Site 18
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Site 19
S282
K
L
M
S
A
N
A
S
D
L
P
L
N
I
E
Site 20
S336
N
L
Q
R
E
D
I
S
S
I
E
I
V
G
G
Site 21
T365
F
L
K
D
I
S
T
T
L
N
A
D
E
A
V
Site 22
S384
A
L
Q
C
A
I
L
S
P
A
F
K
V
R
E
Site 23
T403
D
L
V
P
Y
S
I
T
L
R
W
K
T
S
F
Site 24
T408
S
I
T
L
R
W
K
T
S
F
E
D
G
S
G
Site 25
S409
I
T
L
R
W
K
T
S
F
E
D
G
S
G
E
Site 26
S414
K
T
S
F
E
D
G
S
G
E
C
E
V
F
C
Site 27
S429
K
N
H
P
A
P
F
S
K
V
I
T
F
H
K
Site 28
T433
A
P
F
S
K
V
I
T
F
H
K
K
E
P
F
Site 29
T447
F
E
L
E
A
F
Y
T
N
L
H
E
V
P
Y
Site 30
Y454
T
N
L
H
E
V
P
Y
P
D
A
R
I
G
S
Site 31
S461
Y
P
D
A
R
I
G
S
F
T
I
Q
N
V
F
Site 32
T463
D
A
R
I
G
S
F
T
I
Q
N
V
F
P
Q
Site 33
S471
I
Q
N
V
F
P
Q
S
D
G
D
S
S
K
V
Site 34
S475
F
P
Q
S
D
G
D
S
S
K
V
K
V
K
V
Site 35
S476
P
Q
S
D
G
D
S
S
K
V
K
V
K
V
R
Site 36
S508
Q
N
L
E
G
D
H
S
D
A
P
M
E
T
E
Site 37
S517
A
P
M
E
T
E
T
S
F
K
N
E
N
K
D
Site 38
T545
Q
K
C
H
A
E
H
T
P
E
E
E
I
D
H
Site 39
T553
P
E
E
E
I
D
H
T
G
A
K
T
K
S
A
Site 40
T557
I
D
H
T
G
A
K
T
K
S
A
V
S
D
K
Site 41
S559
H
T
G
A
K
T
K
S
A
V
S
D
K
Q
D
Site 42
T571
K
Q
D
R
L
N
Q
T
L
K
K
G
K
V
K
Site 43
S579
L
K
K
G
K
V
K
S
I
D
L
P
I
Q
S
Site 44
S587
I
D
L
P
I
Q
S
S
L
C
R
Q
L
G
Q
Site 45
S599
L
G
Q
D
L
L
N
S
Y
I
E
N
E
G
K
Site 46
Y600
G
Q
D
L
L
N
S
Y
I
E
N
E
G
K
M
Site 47
Y627
A
K
N
A
V
E
E
Y
V
Y
D
F
R
D
R
Site 48
Y629
N
A
V
E
E
Y
V
Y
D
F
R
D
R
L
G
Site 49
T637
D
F
R
D
R
L
G
T
V
Y
E
K
F
I
T
Site 50
Y639
R
D
R
L
G
T
V
Y
E
K
F
I
T
P
E
Site 51
T644
T
V
Y
E
K
F
I
T
P
E
D
L
S
K
L
Site 52
T658
L
S
A
V
L
E
D
T
E
N
W
L
Y
E
D
Site 53
Y663
E
D
T
E
N
W
L
Y
E
D
G
E
D
Q
P
Site 54
Y674
E
D
Q
P
K
Q
V
Y
V
D
K
L
Q
E
L
Site 55
Y684
K
L
Q
E
L
K
K
Y
G
Q
P
I
Q
M
K
Site 56
Y692
G
Q
P
I
Q
M
K
Y
M
E
H
E
E
R
P
Site 57
Y726
Y
R
N
K
D
E
R
Y
D
H
L
D
P
T
E
Site 58
T732
R
Y
D
H
L
D
P
T
E
M
E
K
V
E
K
Site 59
S759
M
N
A
Q
N
K
L
S
L
T
Q
D
P
V
V
Site 60
T761
A
Q
N
K
L
S
L
T
Q
D
P
V
V
K
V
Site 61
S775
V
S
E
I
V
A
K
S
K
E
L
D
N
F
C
Site 62
S804
E
D
K
P
K
A
N
S
E
H
N
G
P
M
D
Site 63
S814
N
G
P
M
D
G
Q
S
G
T
E
T
K
S
D
Site 64
T816
P
M
D
G
Q
S
G
T
E
T
K
S
D
S
T
Site 65
T818
D
G
Q
S
G
T
E
T
K
S
D
S
T
K
D
Site 66
S820
Q
S
G
T
E
T
K
S
D
S
T
K
D
S
S
Site 67
S822
G
T
E
T
K
S
D
S
T
K
D
S
S
Q
H
Site 68
T823
T
E
T
K
S
D
S
T
K
D
S
S
Q
H
T
Site 69
S826
K
S
D
S
T
K
D
S
S
Q
H
T
K
S
S
Site 70
S827
S
D
S
T
K
D
S
S
Q
H
T
K
S
S
G
Site 71
T830
T
K
D
S
S
Q
H
T
K
S
S
G
E
M
E
Site 72
S832
D
S
S
Q
H
T
K
S
S
G
E
M
E
V
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation