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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP2A1
Full Name:
AP-2 complex subunit alpha-1
Alias:
100 kDa coated vesicle protein A; Adapter-related protein complex 2 alpha 1 subunit; Adapter-related protein complex 2 alpha-1 subunit; Adaptin, alpha; Adaptor protein complex AP-2 alpha-1 subunit; Adaptor-related protein complex 2, alpha 1 subunit; ADTAA; Alpha-adaptin A; CLAPA1; Clathrin assembly protein complex 2 alpha-A large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
Type:
Adaptor/scaffold; Vesicle protein
Mass (Da):
107546
Number AA:
977
UniProt ID:
O95782
International Prot ID:
IPI00304577
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030122
GO:0030130
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006895
GO:0006897
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
Site 2
Y53
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
Site 3
Y58
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
Site 4
Y88
N
L
L
S
S
N
K
Y
T
E
K
Q
I
G
Y
Site 5
T89
L
L
S
S
N
K
Y
T
E
K
Q
I
G
Y
L
Site 6
S160
R
I
L
V
A
G
D
S
M
D
S
V
K
Q
S
Site 7
S163
V
A
G
D
S
M
D
S
V
K
Q
S
A
A
L
Site 8
S167
S
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
Site 9
T224
K
N
P
D
D
F
K
T
C
V
S
L
A
V
S
Site 10
S234
S
L
A
V
S
R
L
S
R
I
V
S
S
A
S
Site 11
S238
S
R
L
S
R
I
V
S
S
A
S
T
D
L
Q
Site 12
T242
R
I
V
S
S
A
S
T
D
L
Q
D
Y
T
Y
Site 13
Y247
A
S
T
D
L
Q
D
Y
T
Y
Y
F
V
P
A
Site 14
T248
S
T
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
Site 15
Y249
T
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
Site 16
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Site 17
Y268
L
L
R
L
L
Q
C
Y
P
P
P
E
D
A
A
Site 18
T286
R
L
V
E
C
L
E
T
V
L
N
K
A
Q
E
Site 19
S297
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
Site 20
S322
S
L
I
I
H
Y
D
S
E
P
N
L
L
V
R
Site 21
T343
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
Site 22
Y347
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
Site 23
S358
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
Site 24
S362
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
Site 25
T368
F
S
H
E
A
V
K
T
H
I
D
T
V
I
N
Site 26
T372
A
V
K
T
H
I
D
T
V
I
N
A
L
K
T
Site 27
T379
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Site 28
S384
L
K
T
E
R
D
V
S
V
R
Q
R
A
A
D
Site 29
Y394
Q
R
A
A
D
L
L
Y
A
M
C
D
R
S
N
Site 30
Y412
I
V
S
E
M
L
R
Y
L
E
T
A
D
Y
A
Site 31
Y418
R
Y
L
E
T
A
D
Y
A
I
R
E
E
I
V
Site 32
Y439
A
E
K
Y
A
V
D
Y
S
W
Y
V
D
T
I
Site 33
S517
L
I
A
G
D
P
R
S
S
P
P
V
Q
F
S
Site 34
S518
I
A
G
D
P
R
S
S
P
P
V
Q
F
S
L
Site 35
S524
S
S
P
P
V
Q
F
S
L
L
H
S
K
F
H
Site 36
S567
Q
G
V
L
R
A
G
S
Q
L
R
N
A
D
V
Site 37
S610
P
P
F
P
E
R
E
S
S
I
L
A
K
L
K
Site 38
S611
P
F
P
E
R
E
S
S
I
L
A
K
L
K
R
Site 39
S626
K
K
G
P
G
A
G
S
A
L
D
D
G
R
R
Site 40
S636
D
D
G
R
R
D
P
S
S
N
D
I
N
G
G
Site 41
S637
D
G
R
R
D
P
S
S
N
D
I
N
G
G
M
Site 42
T647
I
N
G
G
M
E
P
T
P
S
T
V
S
T
P
Site 43
S649
G
G
M
E
P
T
P
S
T
V
S
T
P
S
P
Site 44
T650
G
M
E
P
T
P
S
T
V
S
T
P
S
P
S
Site 45
S652
E
P
T
P
S
T
V
S
T
P
S
P
S
A
D
Site 46
T653
P
T
P
S
T
V
S
T
P
S
P
S
A
D
L
Site 47
S655
P
S
T
V
S
T
P
S
P
S
A
D
L
L
G
Site 48
S657
T
V
S
T
P
S
P
S
A
D
L
L
G
L
R
Site 49
S694
D
G
P
A
A
Q
P
S
L
G
P
T
P
E
E
Site 50
T698
A
Q
P
S
L
G
P
T
P
E
E
A
F
L
S
Site 51
S705
T
P
E
E
A
F
L
S
E
L
E
P
P
A
P
Site 52
S714
L
E
P
P
A
P
E
S
P
M
A
L
L
A
D
Site 53
S767
L
L
Q
I
G
V
K
S
E
F
R
Q
N
L
G
Site 54
Y777
R
Q
N
L
G
R
M
Y
L
F
Y
G
N
K
T
Site 55
Y780
L
G
R
M
Y
L
F
Y
G
N
K
T
S
V
Q
Site 56
S792
S
V
Q
F
Q
N
F
S
P
T
V
V
H
P
G
Site 57
T794
Q
F
Q
N
F
S
P
T
V
V
H
P
G
D
L
Site 58
T836
E
C
L
R
D
F
L
T
P
P
L
L
S
V
R
Site 59
S883
F
Q
R
W
K
Q
L
S
L
P
Q
Q
E
A
Q
Site 60
T957
Q
A
Q
M
Y
R
L
T
L
R
T
S
K
E
P
Site 61
T960
M
Y
R
L
T
L
R
T
S
K
E
P
V
S
R
Site 62
S961
Y
R
L
T
L
R
T
S
K
E
P
V
S
R
H
Site 63
S966
R
T
S
K
E
P
V
S
R
H
L
C
E
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation