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Updated November 2019
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Protein Info
Short Name:
WIZ
Full Name:
Protein Wiz
Alias:
Widely-interspaced zinc finger-containing protein; Zinc finger protein 803
Type:
Mass (Da):
178674
Number AA:
1651
UniProt ID:
O95785
International Prot ID:
IPI00792809
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0008270
GO:0008270
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
G
S
L
A
G
S
L
A
A
P
D
R
P
Site 2
S46
G
E
G
G
I
F
R
S
T
R
Y
L
P
V
T
Site 3
T47
E
G
G
I
F
R
S
T
R
Y
L
P
V
T
K
Site 4
Y49
G
I
F
R
S
T
R
Y
L
P
V
T
K
E
G
Site 5
T53
S
T
R
Y
L
P
V
T
K
E
G
P
R
D
I
Site 6
S68
L
D
G
R
G
G
I
S
G
T
P
D
G
R
G
Site 7
T70
G
R
G
G
I
S
G
T
P
D
G
R
G
P
W
Site 8
S91
E
A
G
E
G
I
L
S
E
R
R
F
E
D
S
Site 9
S98
S
E
R
R
F
E
D
S
V
I
V
R
T
M
K
Site 10
S113
P
H
A
E
L
E
G
S
R
R
F
L
H
H
R
Site 11
S147
Q
D
E
D
E
Q
G
S
P
Q
D
A
G
L
H
Site 12
S202
L
E
G
L
A
Q
P
S
E
W
G
L
P
T
S
Site 13
S209
S
E
W
G
L
P
T
S
A
S
E
V
A
T
Q
Site 14
S211
W
G
L
P
T
S
A
S
E
V
A
T
Q
T
W
Site 15
T215
T
S
A
S
E
V
A
T
Q
T
W
T
V
N
S
Site 16
T219
E
V
A
T
Q
T
W
T
V
N
S
E
A
S
V
Site 17
Y241
P
P
I
R
T
G
P
Y
L
C
E
L
L
E
E
Site 18
S255
E
V
A
E
G
V
A
S
P
D
E
D
E
D
E
Site 19
Y275
P
C
I
E
C
S
I
Y
F
K
Q
K
E
H
L
Site 20
S287
E
H
L
L
E
H
M
S
Q
H
R
R
A
P
G
Site 21
Y368
G
T
N
S
S
R
A
Y
V
Q
H
A
K
L
H
Site 22
T384
R
E
P
P
G
Q
T
T
K
E
P
F
G
G
S
Site 23
S392
K
E
P
F
G
G
S
S
G
A
G
S
P
S
P
Site 24
S396
G
G
S
S
G
A
G
S
P
S
P
E
A
S
A
Site 25
S398
S
S
G
A
G
S
P
S
P
E
A
S
A
L
L
Site 26
S402
G
S
P
S
P
E
A
S
A
L
L
Y
Q
P
Y
Site 27
S429
G
F
P
A
P
S
E
S
L
L
R
E
H
V
R
Site 28
S457
A
Y
E
E
D
P
A
S
Q
P
G
T
S
Q
D
Site 29
T461
D
P
A
S
Q
P
G
T
S
Q
D
A
H
A
C
Site 30
S462
P
A
S
Q
P
G
T
S
Q
D
A
H
A
C
F
Site 31
Y476
F
P
D
T
A
V
D
Y
F
G
K
A
E
P
S
Site 32
S483
Y
F
G
K
A
E
P
S
L
A
P
M
W
R
E
Site 33
S498
N
P
A
G
Y
D
P
S
L
A
F
G
P
G
C
Site 34
S509
G
P
G
C
Q
Q
L
S
I
R
D
F
P
L
S
Site 35
S516
S
I
R
D
F
P
L
S
K
P
L
L
H
G
T
Site 36
T523
S
K
P
L
L
H
G
T
G
Q
R
P
L
G
R
Site 37
T536
G
R
L
A
F
P
S
T
L
A
S
T
P
Y
S
Site 38
Y542
S
T
L
A
S
T
P
Y
S
L
Q
L
G
R
N
Site 39
S543
T
L
A
S
T
P
Y
S
L
Q
L
G
R
N
K
Site 40
S551
L
Q
L
G
R
N
K
S
T
V
H
P
Q
G
L
Site 41
T552
Q
L
G
R
N
K
S
T
V
H
P
Q
G
L
G
Site 42
S566
G
E
R
R
R
P
W
S
E
E
E
E
E
E
E
Site 43
S582
E
E
D
V
V
L
T
S
E
M
D
F
S
P
E
Site 44
S587
L
T
S
E
M
D
F
S
P
E
N
G
V
F
S
Site 45
S594
S
P
E
N
G
V
F
S
P
L
A
T
P
S
L
Site 46
Y731
L
N
R
V
G
V
S
Y
N
V
R
H
F
I
S
Site 47
S750
K
A
I
E
R
R
F
S
F
Q
K
K
K
K
K
Site 48
T765
V
A
N
F
D
P
G
T
F
S
L
M
R
C
D
Site 49
T780
F
C
G
A
G
F
D
T
R
A
G
L
S
S
H
Site 50
S786
D
T
R
A
G
L
S
S
H
A
R
A
H
L
R
Site 51
S805
T
N
W
E
L
T
V
S
P
I
N
I
L
Q
E
Site 52
S824
S
A
A
E
Q
P
P
S
P
L
G
R
E
P
G
Site 53
S836
E
P
G
G
P
P
G
S
F
L
T
S
R
R
P
Site 54
T839
G
P
P
G
S
F
L
T
S
R
R
P
R
L
P
Site 55
S840
P
P
G
S
F
L
T
S
R
R
P
R
L
P
L
Site 56
T848
R
R
P
R
L
P
L
T
V
P
F
P
P
T
W
Site 57
T854
L
T
V
P
F
P
P
T
W
A
E
D
P
G
P
Site 58
Y863
A
E
D
P
G
P
A
Y
G
D
A
Q
S
L
T
Site 59
S868
P
A
Y
G
D
A
Q
S
L
T
T
C
E
V
C
Site 60
S886
F
E
T
R
K
G
L
S
S
H
A
R
S
H
L
Site 61
S887
E
T
R
K
G
L
S
S
H
A
R
S
H
L
R
Site 62
S891
G
L
S
S
H
A
R
S
H
L
R
Q
L
G
V
Site 63
S901
R
Q
L
G
V
A
E
S
E
S
S
G
A
P
I
Site 64
Y912
G
A
P
I
D
L
L
Y
E
L
V
K
Q
K
G
Site 65
S935
P
P
G
L
A
K
K
S
S
S
L
K
E
V
V
Site 66
S936
P
G
L
A
K
K
S
S
S
L
K
E
V
V
A
Site 67
S937
G
L
A
K
K
S
S
S
L
K
E
V
V
A
G
Site 68
S968
A
V
N
K
A
I
K
S
P
P
G
F
S
A
K
Site 69
S973
I
K
S
P
P
G
F
S
A
K
G
L
G
H
P
Site 70
S982
K
G
L
G
H
P
P
S
S
P
L
L
K
K
T
Site 71
S983
G
L
G
H
P
P
S
S
P
L
L
K
K
T
P
Site 72
T989
S
S
P
L
L
K
K
T
P
L
A
L
A
G
S
Site 73
S996
T
P
L
A
L
A
G
S
P
T
P
K
N
P
E
Site 74
T998
L
A
L
A
G
S
P
T
P
K
N
P
E
D
K
Site 75
S1006
P
K
N
P
E
D
K
S
P
Q
L
S
L
S
P
Site 76
S1010
E
D
K
S
P
Q
L
S
L
S
P
R
P
A
S
Site 77
S1012
K
S
P
Q
L
S
L
S
P
R
P
A
S
P
K
Site 78
S1017
S
L
S
P
R
P
A
S
P
K
A
Q
W
P
Q
Site 79
S1025
P
K
A
Q
W
P
Q
S
E
D
E
G
P
L
N
Site 80
T1034
D
E
G
P
L
N
L
T
S
G
P
E
P
A
R
Site 81
S1035
E
G
P
L
N
L
T
S
G
P
E
P
A
R
D
Site 82
S1059
F
E
N
R
K
G
L
S
S
H
A
R
S
H
L
Site 83
S1060
E
N
R
K
G
L
S
S
H
A
R
S
H
L
R
Site 84
S1064
G
L
S
S
H
A
R
S
H
L
R
Q
M
G
V
Site 85
Y1075
Q
M
G
V
T
E
W
Y
V
N
G
S
P
I
D
Site 86
S1079
T
E
W
Y
V
N
G
S
P
I
D
T
L
R
E
Site 87
T1083
V
N
G
S
P
I
D
T
L
R
E
I
L
K
R
Site 88
T1092
R
E
I
L
K
R
R
T
Q
S
R
P
G
G
P
Site 89
S1094
I
L
K
R
R
T
Q
S
R
P
G
G
P
P
N
Site 90
S1106
P
P
N
P
P
G
P
S
P
K
A
L
A
K
M
Site 91
S1121
M
G
G
A
G
P
G
S
S
L
E
A
R
S
P
Site 92
S1122
G
G
A
G
P
G
S
S
L
E
A
R
S
P
S
Site 93
S1127
G
S
S
L
E
A
R
S
P
S
D
L
H
I
S
Site 94
S1129
S
L
E
A
R
S
P
S
D
L
H
I
S
P
L
Site 95
S1134
S
P
S
D
L
H
I
S
P
L
A
K
K
L
P
Site 96
S1146
K
L
P
P
P
P
G
S
P
L
G
H
S
P
T
Site 97
S1151
P
G
S
P
L
G
H
S
P
T
A
S
P
P
P
Site 98
T1153
S
P
L
G
H
S
P
T
A
S
P
P
P
T
A
Site 99
S1155
L
G
H
S
P
T
A
S
P
P
P
T
A
R
K
Site 100
T1159
P
T
A
S
P
P
P
T
A
R
K
M
F
P
G
Site 101
S1171
F
P
G
L
A
A
P
S
L
P
K
K
L
K
P
Site 102
S1201
L
H
G
E
L
H
P
S
E
G
P
W
G
A
P
Site 103
T1213
G
A
P
R
E
D
M
T
P
L
N
L
S
S
R
Site 104
S1218
D
M
T
P
L
N
L
S
S
R
A
E
P
V
R
Site 105
T1256
H
L
R
Q
M
G
V
T
E
W
S
V
N
G
S
Site 106
S1259
Q
M
G
V
T
E
W
S
V
N
G
S
P
I
D
Site 107
S1263
T
E
W
S
V
N
G
S
P
I
D
T
L
R
E
Site 108
T1267
V
N
G
S
P
I
D
T
L
R
E
I
L
K
K
Site 109
S1276
R
E
I
L
K
K
K
S
K
P
C
L
I
K
K
Site 110
T1301
L
A
E
D
G
P
P
T
V
A
P
G
P
V
Q
Site 111
S1309
V
A
P
G
P
V
Q
S
P
L
P
L
S
P
L
Site 112
S1314
V
Q
S
P
L
P
L
S
P
L
A
G
R
P
G
Site 113
T1337
V
P
R
E
L
S
L
T
P
I
T
G
A
K
P
Site 114
S1345
P
I
T
G
A
K
P
S
A
T
G
Y
L
G
S
Site 115
Y1349
A
K
P
S
A
T
G
Y
L
G
S
V
A
A
K
Site 116
S1352
S
A
T
G
Y
L
G
S
V
A
A
K
R
P
L
Site 117
T1377
K
A
K
T
Y
I
Q
T
E
L
P
F
K
A
K
Site 118
T1385
E
L
P
F
K
A
K
T
L
H
E
K
T
S
H
Site 119
T1390
A
K
T
L
H
E
K
T
S
H
S
S
T
E
A
Site 120
S1391
K
T
L
H
E
K
T
S
H
S
S
T
E
A
C
Site 121
T1395
E
K
T
S
H
S
S
T
E
A
C
C
E
L
C
Site 122
S1414
E
N
R
K
A
L
A
S
H
A
R
A
H
L
R
Site 123
S1433
T
E
W
C
V
N
G
S
P
I
E
T
L
S
E
Site 124
T1437
V
N
G
S
P
I
E
T
L
S
E
W
I
K
H
Site 125
S1439
G
S
P
I
E
T
L
S
E
W
I
K
H
R
P
Site 126
S1454
Q
K
V
G
A
Y
R
S
Y
I
Q
G
G
R
P
Site 127
Y1455
K
V
G
A
Y
R
S
Y
I
Q
G
G
R
P
F
Site 128
T1463
I
Q
G
G
R
P
F
T
K
K
F
R
S
A
G
Site 129
S1468
P
F
T
K
K
F
R
S
A
G
H
G
R
D
S
Site 130
S1475
S
A
G
H
G
R
D
S
D
K
R
P
S
L
G
Site 131
S1480
R
D
S
D
K
R
P
S
L
G
L
A
P
G
G
Site 132
S1517
G
E
R
P
L
A
A
S
P
P
G
T
V
K
A
Site 133
T1521
L
A
A
S
P
P
G
T
V
K
A
E
E
H
Q
Site 134
S1546
Q
A
R
P
P
D
A
S
A
A
R
G
G
E
D
Site 135
T1554
A
A
R
G
G
E
D
T
N
D
L
Q
Q
K
L
Site 136
S1576
P
R
V
R
P
V
P
S
L
V
P
R
P
P
Q
Site 137
S1585
V
P
R
P
P
Q
T
S
L
V
K
F
V
G
N
Site 138
Y1594
V
K
F
V
G
N
I
Y
T
L
K
C
R
F
C
Site 139
S1610
V
E
F
Q
G
P
L
S
I
Q
E
E
W
V
R
Site 140
S1629
H
I
L
E
M
N
F
S
K
A
D
P
P
P
E
Site 141
S1638
A
D
P
P
P
E
E
S
Q
A
P
Q
A
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
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2019 Kinexus Bioinformatics Corporation