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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NDST3
Full Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Alias:
Heparan sulfate N- sulfotransferase 3; Heparan sulfate N-sulfotransferase 3; HSST3; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Type:
Hydrolase; EC 3.-.-.-; EC 2.8.2.8; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.8.2.-; Transferase
Mass (Da):
100902
Number AA:
873
UniProt ID:
O95803
International Prot ID:
IPI00329497
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0015016
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
L
H
R
H
F
Q
R
T
V
I
L
L
A
T
F
Site 2
S44
Y
K
Q
E
N
E
L
S
E
T
A
S
E
V
D
Site 3
T46
Q
E
N
E
L
S
E
T
A
S
E
V
D
C
G
Site 4
S48
N
E
L
S
E
T
A
S
E
V
D
C
G
D
L
Site 5
Y60
G
D
L
Q
H
L
P
Y
Q
L
M
E
V
K
A
Site 6
T79
D
A
S
R
T
D
P
T
V
L
V
F
V
E
S
Site 7
Y106
L
E
S
S
R
F
Q
Y
H
I
E
I
A
P
G
Site 8
Y139
I
Y
E
N
I
L
K
Y
I
N
M
D
S
W
N
Site 9
S144
L
K
Y
I
N
M
D
S
W
N
R
S
L
L
D
Site 10
Y153
N
R
S
L
L
D
K
Y
C
V
E
Y
G
V
G
Site 11
T167
G
V
I
G
F
H
K
T
S
E
K
S
V
Q
S
Site 12
S168
V
I
G
F
H
K
T
S
E
K
S
V
Q
S
F
Site 13
S171
F
H
K
T
S
E
K
S
V
Q
S
F
Q
L
K
Site 14
S174
T
S
E
K
S
V
Q
S
F
Q
L
K
G
F
P
Site 15
Y185
K
G
F
P
F
S
I
Y
G
N
L
A
V
K
D
Site 16
T205
H
S
P
L
I
R
V
T
K
S
S
K
L
E
K
Site 17
S207
P
L
I
R
V
T
K
S
S
K
L
E
K
G
S
Site 18
S208
L
I
R
V
T
K
S
S
K
L
E
K
G
S
L
Site 19
S214
S
S
K
L
E
K
G
S
L
P
G
T
D
W
T
Site 20
T218
E
K
G
S
L
P
G
T
D
W
T
V
F
Q
I
Site 21
T221
S
L
P
G
T
D
W
T
V
F
Q
I
N
H
S
Site 22
Y230
F
Q
I
N
H
S
A
Y
Q
P
V
I
F
A
K
Site 23
T240
V
I
F
A
K
V
K
T
P
E
N
L
S
P
S
Site 24
S245
V
K
T
P
E
N
L
S
P
S
I
S
K
G
A
Site 25
S247
T
P
E
N
L
S
P
S
I
S
K
G
A
F
Y
Site 26
S249
E
N
L
S
P
S
I
S
K
G
A
F
Y
A
T
Site 27
T256
S
K
G
A
F
Y
A
T
I
I
H
D
L
G
L
Site 28
T298
F
L
S
G
K
R
L
T
L
S
L
D
R
Y
I
Site 29
T323
K
E
G
T
R
M
N
T
N
D
V
K
A
L
L
Site 30
T344
R
A
Q
I
T
N
F
T
F
N
L
G
F
S
G
Site 31
Y354
L
G
F
S
G
K
F
Y
H
T
G
T
E
E
E
Site 32
S394
P
H
L
F
H
N
E
S
S
L
V
E
Q
M
I
Site 33
Y418
G
I
P
T
D
M
G
Y
A
V
A
P
H
H
S
Site 34
Y428
A
P
H
H
S
G
V
Y
P
V
H
V
Q
L
Y
Site 35
Y435
Y
P
V
H
V
Q
L
Y
E
A
W
K
K
V
W
Site 36
Y452
K
I
T
S
T
E
E
Y
P
H
L
K
P
A
R
Site 37
Y460
P
H
L
K
P
A
R
Y
R
R
G
F
I
H
K
Site 38
Y486
L
F
T
H
T
I
F
Y
K
E
Y
P
G
G
P
Site 39
Y489
H
T
I
F
Y
K
E
Y
P
G
G
P
K
E
L
Site 40
S499
G
P
K
E
L
D
K
S
I
Q
G
G
E
L
F
Site 41
T519
N
P
I
S
I
F
M
T
H
L
S
N
Y
G
N
Site 42
Y524
F
M
T
H
L
S
N
Y
G
N
D
R
L
G
L
Site 43
Y532
G
N
D
R
L
G
L
Y
T
F
V
N
L
A
N
Site 44
S543
N
L
A
N
F
V
K
S
W
T
N
L
R
L
Q
Site 45
Y561
P
V
Q
L
A
H
K
Y
F
E
L
F
P
D
Q
Site 46
T591
D
I
W
S
K
E
K
T
C
D
R
L
P
K
F
Site 47
S623
V
M
H
P
S
I
L
S
N
S
P
S
P
K
T
Site 48
S625
H
P
S
I
L
S
N
S
P
S
P
K
T
F
E
Site 49
S627
S
I
L
S
N
S
P
S
P
K
T
F
E
E
V
Site 50
T630
S
N
S
P
S
P
K
T
F
E
E
V
Q
F
F
Site 51
T661
P
V
P
S
N
V
T
T
D
F
L
F
E
K
S
Site 52
Y671
L
F
E
K
S
A
N
Y
F
H
S
E
E
A
P
Site 53
S683
E
A
P
K
R
A
A
S
L
V
P
K
A
K
I
Site 54
S698
I
T
I
L
I
D
P
S
D
R
A
Y
S
W
Y
Site 55
Y702
I
D
P
S
D
R
A
Y
S
W
Y
Q
H
Q
R
Site 56
S703
D
P
S
D
R
A
Y
S
W
Y
Q
H
Q
R
S
Site 57
Y705
S
D
R
A
Y
S
W
Y
Q
H
Q
R
S
H
E
Site 58
S726
F
S
F
Y
E
V
I
S
A
G
P
R
A
P
S
Site 59
S733
S
A
G
P
R
A
P
S
E
L
R
A
L
Q
K
Site 60
T778
Q
L
R
T
D
P
A
T
V
M
D
E
V
Q
K
Site 61
Y795
G
V
L
P
H
Y
N
Y
S
E
A
L
T
F
D
Site 62
T800
Y
N
Y
S
E
A
L
T
F
D
S
H
K
G
F
Site 63
T817
Q
L
L
E
E
G
K
T
K
C
L
G
K
S
K
Site 64
S823
K
T
K
C
L
G
K
S
K
G
R
K
Y
P
P
Site 65
Y828
G
K
S
K
G
R
K
Y
P
P
M
D
S
D
S
Site 66
S833
R
K
Y
P
P
M
D
S
D
S
R
T
F
L
S
Site 67
S835
Y
P
P
M
D
S
D
S
R
T
F
L
S
S
Y
Site 68
T837
P
M
D
S
D
S
R
T
F
L
S
S
Y
Y
R
Site 69
S840
S
D
S
R
T
F
L
S
S
Y
Y
R
D
H
N
Site 70
S841
D
S
R
T
F
L
S
S
Y
Y
R
D
H
N
V
Site 71
Y842
S
R
T
F
L
S
S
Y
Y
R
D
H
N
V
E
Site 72
S863
K
L
G
Q
P
L
P
S
W
L
R
Q
E
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation