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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AIFM1
Full Name:
Apoptosis-inducing factor 1, mitochondrial
Alias:
Aif; Apoptosis-inducing factor; Apoptosis-inducing factor, mitochondrion-associated, 1; Programmed cell death protein 8; Programmed cell death protein 8, mitochondrial
Type:
EC 1.-.-.-; Apoptosis; Mitochondrial; Oxidoreductase
Mass (Da):
66901
Number AA:
613
UniProt ID:
O95831
International Prot ID:
IPI00000690
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005758
GO:0005634
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0050660
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0008630
GO:0006309
GO:0045454
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
V
R
T
V
C
V
R
S
P
R
Q
R
N
R
L
Site 2
T51
V
P
L
E
L
Q
M
T
R
Q
M
A
S
S
G
Site 3
S56
Q
M
T
R
Q
M
A
S
S
G
A
S
G
G
K
Site 4
S57
M
T
R
Q
M
A
S
S
G
A
S
G
G
K
I
Site 5
S60
Q
M
A
S
S
G
A
S
G
G
K
I
D
N
S
Site 6
Y85
V
G
A
G
A
Y
A
Y
K
T
M
K
E
D
E
Site 7
T87
A
G
A
Y
A
Y
K
T
M
K
E
D
E
K
R
Site 8
Y95
M
K
E
D
E
K
R
Y
N
E
R
I
S
G
L
Site 9
S100
K
R
Y
N
E
R
I
S
G
L
G
L
T
P
E
Site 10
T105
R
I
S
G
L
G
L
T
P
E
Q
K
Q
K
K
Site 11
S116
K
Q
K
K
A
A
L
S
A
S
E
G
E
E
V
Site 12
S149
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
Site 13
Y170
S
E
D
P
E
L
P
Y
M
R
P
P
L
S
K
Site 14
S176
P
Y
M
R
P
P
L
S
K
E
L
W
F
S
D
Site 15
S182
L
S
K
E
L
W
F
S
D
D
P
N
V
T
K
Site 16
T190
D
D
P
N
V
T
K
T
L
R
F
K
Q
W
N
Site 17
S202
Q
W
N
G
K
E
R
S
I
Y
F
Q
P
P
S
Site 18
Y204
N
G
K
E
R
S
I
Y
F
Q
P
P
S
F
Y
Site 19
S209
S
I
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
Site 20
Y211
Y
F
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
Site 21
S213
Q
P
P
S
F
Y
V
S
A
Q
D
L
P
H
I
Site 22
Y253
N
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
Site 23
S266
A
T
G
G
T
P
R
S
L
S
A
I
D
R
A
Site 24
S268
G
G
T
P
R
S
L
S
A
I
D
R
A
G
A
Site 25
S279
R
A
G
A
E
V
K
S
R
T
T
L
F
R
K
Site 26
T282
A
E
V
K
S
R
T
T
L
F
R
K
I
G
D
Site 27
S292
R
K
I
G
D
F
R
S
L
E
K
I
S
R
E
Site 28
T328
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
Site 29
Y347
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
Site 30
T409
P
N
V
E
L
A
K
T
G
G
L
E
I
D
S
Site 31
S416
T
G
G
L
E
I
D
S
D
F
G
G
F
R
V
Site 32
Y443
A
G
D
A
A
C
F
Y
D
I
K
L
G
R
R
Site 33
S461
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
Site 34
S519
T
A
Q
D
N
P
K
S
A
T
E
Q
S
G
T
Site 35
T526
S
A
T
E
Q
S
G
T
G
I
R
S
E
S
E
Site 36
S530
Q
S
G
T
G
I
R
S
E
S
E
T
E
S
E
Site 37
S532
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
Site 38
T534
G
I
R
S
E
S
E
T
E
S
E
A
S
E
I
Site 39
S536
R
S
E
S
E
T
E
S
E
A
S
E
I
T
I
Site 40
S539
S
E
T
E
S
E
A
S
E
I
T
I
P
P
S
Site 41
T542
E
S
E
A
S
E
I
T
I
P
P
S
T
P
A
Site 42
S546
S
E
I
T
I
P
P
S
T
P
A
V
P
Q
A
Site 43
T547
E
I
T
I
P
P
S
T
P
A
V
P
Q
A
P
Site 44
Y560
A
P
V
Q
G
E
D
Y
G
K
G
V
I
F
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation