PhosphoNET

           
Protein Info 
   
Short Name:  LATS1
Full Name:  Serine/threonine-protein kinase LATS1
Alias:  EC 2.7.11.1; Large tumor suppressor 1; LATS, large tumor suppressor, 1; WARTS
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family
Mass (Da):  126870
Number AA:  1130
UniProt ID:  O95835
International Prot ID:  IPI00005858
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005813  GO:0000922   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0000287  GO:0019901 PhosphoSite+ KinaseNET
Biological Process:  GO:0000086  GO:0051301  GO:0009755 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T17YRQMRPKTFPASNYT
Site 2S21RPKTFPASNYTVSSR
Site 3Y23KTFPASNYTVSSRQM
Site 4T24TFPASNYTVSSRQML
Site 5S26PASNYTVSSRQMLQE
Site 6S27ASNYTVSSRQMLQEI
Site 7S37MLQEIRESLRNLSKP
Site 8S42RESLRNLSKPSDAAK
Site 9T59HNMSKMSTEDPRQVR
Site 10S84ALQEIRNSLLPFANE
Site 11T92LLPFANETNSSRSTS
Site 12S94PFANETNSSRSTSEV
Site 13S95FANETNSSRSTSEVN
Site 14T98ETNSSRSTSEVNPQM
Site 15S99TNSSRSTSEVNPQML
Site 16T126VIQALQKTNNRSIEA
Site 17Y143EFISKMSYQDPRREQ
Site 18S162AARPINASMKPGNVQ
Site 19S171KPGNVQQSVNRKQSW
Site 20S177QSVNRKQSWKGSKES
Site 21S181RKQSWKGSKESLVPQ
Site 22S184SWKGSKESLVPQRHG
Site 23S197HGPPLGESVAYHSES
Site 24Y200PLGESVAYHSESPNS
Site 25S202GESVAYHSESPNSQT
Site 26S204SVAYHSESPNSQTDV
Site 27S207YHSESPNSQTDVGRP
Site 28T209SESPNSQTDVGRPLS
Site 29S216TDVGRPLSGSGISAF
Site 30S229AFVQAHPSNGQRVNP
Site 31S244PPPPQVRSVTPPPPP
Site 32T246PPQVRSVTPPPPPRG
Site 33T255PPPPRGQTPPPRGTT
Site 34T261QTPPPRGTTPPPPSW
Site 35T262TPPPRGTTPPPPSWE
Site 36S267GTTPPPPSWEPNSQT
Site 37S272PPSWEPNSQTKRYSG
Site 38T274SWEPNSQTKRYSGNM
Site 39Y277PNSQTKRYSGNMEYV
Site 40S278NSQTKRYSGNMEYVI
Site 41Y283RYSGNMEYVISRISP
Site 42S286GNMEYVISRISPVPP
Site 43Y300PGAWQEGYPPPPLNT
Site 44S308PPPPLNTSPMNPPNQ
Site 45S321NQGQRGISSVPVGRQ
Site 46S322QGQRGISSVPVGRQP
Site 47S334RQPIIMQSSSKFNFP
Site 48S336PIIMQSSSKFNFPSG
Site 49S342SSKFNFPSGRPGMQN
Site 50T367QNVVPAGTVNRQPPP
Site 51Y376NRQPPPPYPLTAANG
Site 52T379PPPPYPLTAANGQSP
Site 53S385LTAANGQSPSALQTG
Site 54S387AANGQSPSALQTGGS
Site 55T391QSPSALQTGGSAAPS
Site 56S394SALQTGGSAAPSSYT
Site 57S398TGGSAAPSSYTNGSI
Site 58S399GGSAAPSSYTNGSIP
Site 59Y400GSAAPSSYTNGSIPQ
Site 60S404PSSYTNGSIPQSMMV
Site 61S408TNGSIPQSMMVPNRN
Site 62Y422NSHNMELYNISVPGL
Site 63T431ISVPGLQTNWPQSSS
Site 64S436LQTNWPQSSSAPAQS
Site 65S437QTNWPQSSSAPAQSS
Site 66S438TNWPQSSSAPAQSSP
Site 67S443SSSAPAQSSPSSGHE
Site 68S444SSAPAQSSPSSGHEI
Site 69S447PAQSSPSSGHEIPTW
Site 70T453SSGHEIPTWQPNIPV
Site 71S462QPNIPVRSNSFNNPL
Site 72S464NIPVRSNSFNNPLGN
Site 73S474NPLGNRASHSANSQP
Site 74S476LGNRASHSANSQPSA
Site 75S479RASHSANSQPSATTV
Site 76T490ATTVTAITPAPIQQP
Site 77S500PIQQPVKSMRVLKPE
Site 78S518ALAPTHPSWIPQPIQ
Site 79T526WIPQPIQTVQPSPFP
Site 80S530PIQTVQPSPFPEGTA
Site 81T536PSPFPEGTASNVTVM
Site 82S538PFPEGTASNVTVMPP
Site 83Y552PVAEAPNYQGPPPPY
Site 84Y559YQGPPPPYPKHLLHQ
Site 85S569HLLHQNPSVPPYESI
Site 86Y573QNPSVPPYESISKPS
Site 87S575PSVPPYESISKPSKE
Site 88S577VPPYESISKPSKEDQ
Site 89S586PSKEDQPSLPKEDES
Site 90S593SLPKEDESEKSYENV
Site 91S596KEDESEKSYENVDSG
Site 92Y597EDESEKSYENVDSGD
Site 93S602KSYENVDSGDKEKKQ
Site 94T611DKEKKQITTSPITVR
Site 95T612KEKKQITTSPITVRK
Site 96S613EKKQITTSPITVRKN
Site 97T616QITTSPITVRKNKKD
Site 98S629KDEERRESRIQSYSP
Site 99S633RRESRIQSYSPQAFK
Site 100S635ESRIQSYSPQAFKFF
Site 101S653HVENVLKSHQQRLHR
Site 102S674EMMRVGLSQDAQDQM
Site 103Y692LCQKESNYIRLKRAK
Site 104S703KRAKMDKSMFVKIKT
Site 105Y731KVDTKALYATKTLRK
Site 106T735KALYATKTLRKKDVL
Site 107Y769NEWVVRLYYSFQDKD
Site 108Y770EWVVRLYYSFQDKDN
Site 109Y779FQDKDNLYFVMDYIP
Site 110T845RDGHIKLTDFGLCTG
Site 111Y861RWTHDSKYYQSGDHP
Site 112S864HDSKYYQSGDHPRQD
Site 113S872GDHPRQDSMDFSNEW
Site 114S876RQDSMDFSNEWGDPS
Site 115S883SNEWGDPSSCRCGDR
Site 116S884NEWGDPSSCRCGDRL
Site 117S909HQRCLAHSLVGTPNY
Site 118Y927EVLLRTGYTQLCDWW
Site 119T954QPPFLAQTPLETQMK
Site 120T967MKVINWQTSLHIPPQ
Site 121S978IPPQAKLSPEASDLI
Site 122T1012KAHPFFKTIDFSSDL
Site 123S1016FFKTIDFSSDLRQQS
Site 124S1017FKTIDFSSDLRQQSA
Site 125S1023SSDLRQQSASYIPKI
Site 126S1025DLRQQSASYIPKITH
Site 127T1036KITHPTDTSNFDPVD
Site 128S1049VDPDKLWSDDNEEEN
Site 129T1060EEENVNDTLNGWYKN
Site 130Y1076KHPEHAFYEFTFRRF
Site 131T1079EHAFYEFTFRRFFDD
Site 132Y1089RFFDDNGYPYNYPKP
Site 133Y1091FDDNGYPYNYPKPIE
Site 134Y1093DNGYPYNYPKPIEYE
Site 135Y1099NYPKPIEYEYINSQG
Site 136Y1101PKPIEYEYINSQGSE
Site 137S1104IEYEYINSQGSEQQS
Site 138S1111SQGSEQQSDEDDQNT
Site 139T1118SDEDDQNTGSEIKNR
Site 140S1120EDDQNTGSEIKNRDL
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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