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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAPAP3
Full Name:
Disks large-associated protein 3
Alias:
DAP3; DAP-3; Discs, large-associated protein 3; DLGAP3; DLGP3; PSD-95/SAP90-binding protein 3; SAP90/PSD-95-associated protein 3
Type:
Membrane protein, peripheral; Adaptor/scaffold
Mass (Da):
106040
Number AA:
979
UniProt ID:
O95886
International Prot ID:
IPI00219434
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0014069
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
Y
H
G
D
R
G
S
H
P
R
P
A
R
F
Site 2
Y33
G
P
A
A
R
A
P
Y
L
L
G
S
R
E
A
Site 3
S37
R
A
P
Y
L
L
G
S
R
E
A
F
S
T
E
Site 4
T43
G
S
R
E
A
F
S
T
E
P
R
F
C
A
P
Site 5
S58
R
A
G
L
G
H
I
S
P
E
G
P
L
S
L
Site 6
S64
I
S
P
E
G
P
L
S
L
S
E
G
P
S
V
Site 7
S66
P
E
G
P
L
S
L
S
E
G
P
S
V
G
P
Site 8
S70
L
S
L
S
E
G
P
S
V
G
P
E
G
G
P
Site 9
S87
A
G
V
G
G
G
S
S
T
F
P
R
M
Y
P
Site 10
T88
G
V
G
G
G
S
S
T
F
P
R
M
Y
P
G
Site 11
Y93
S
S
T
F
P
R
M
Y
P
G
Q
G
P
F
D
Site 12
T120
G
A
P
R
L
P
P
T
L
L
D
Q
F
E
K
Site 13
Y141
D
G
F
H
T
L
P
Y
Q
R
G
P
A
G
A
Site 14
S164
G
T
A
P
E
P
R
S
E
S
P
S
R
I
R
Site 15
S166
A
P
E
P
R
S
E
S
P
S
R
I
R
H
L
Site 16
S168
E
P
R
S
E
S
P
S
R
I
R
H
L
V
H
Site 17
S176
R
I
R
H
L
V
H
S
V
Q
K
L
F
A
K
Site 18
S184
V
Q
K
L
F
A
K
S
H
S
L
E
A
P
G
Site 19
S186
K
L
F
A
K
S
H
S
L
E
A
P
G
K
R
Site 20
Y195
E
A
P
G
K
R
D
Y
N
G
P
K
A
E
G
Site 21
S206
K
A
E
G
R
G
G
S
G
G
D
S
Y
P
G
Site 22
S210
R
G
G
S
G
G
D
S
Y
P
G
P
G
S
G
Site 23
Y211
G
G
S
G
G
D
S
Y
P
G
P
G
S
G
G
Site 24
S216
D
S
Y
P
G
P
G
S
G
G
P
H
T
S
H
Site 25
S242
Q
S
R
H
G
K
R
S
K
S
K
D
R
K
G
Site 26
S244
R
H
G
K
R
S
K
S
K
D
R
K
G
D
G
Site 27
S257
D
G
R
H
Q
A
K
S
T
G
W
W
S
S
D
Site 28
T258
G
R
H
Q
A
K
S
T
G
W
W
S
S
D
D
Site 29
S263
K
S
T
G
W
W
S
S
D
D
N
L
D
S
D
Site 30
S269
S
S
D
D
N
L
D
S
D
S
G
F
L
A
G
Site 31
S271
D
D
N
L
D
S
D
S
G
F
L
A
G
G
R
Site 32
S295
C
L
E
G
P
D
G
S
Y
R
D
L
S
F
K
Site 33
Y296
L
E
G
P
D
G
S
Y
R
D
L
S
F
K
G
Site 34
S300
D
G
S
Y
R
D
L
S
F
K
G
R
S
G
G
Site 35
S305
D
L
S
F
K
G
R
S
G
G
S
E
G
R
C
Site 36
S308
F
K
G
R
S
G
G
S
E
G
R
C
L
A
C
Site 37
T316
E
G
R
C
L
A
C
T
G
M
S
M
S
L
D
Site 38
S321
A
C
T
G
M
S
M
S
L
D
G
Q
S
V
K
Site 39
S326
S
M
S
L
D
G
Q
S
V
K
R
S
A
W
H
Site 40
T334
V
K
R
S
A
W
H
T
M
M
V
S
Q
G
R
Site 41
S338
A
W
H
T
M
M
V
S
Q
G
R
D
G
Y
P
Site 42
Y344
V
S
Q
G
R
D
G
Y
P
G
A
G
P
G
K
Site 43
T358
K
G
L
L
G
P
E
T
K
A
K
A
R
T
Y
Site 44
Y365
T
K
A
K
A
R
T
Y
H
Y
L
Q
V
P
Q
Site 45
Y367
A
K
A
R
T
Y
H
Y
L
Q
V
P
Q
D
D
Site 46
Y378
P
Q
D
D
W
G
G
Y
P
T
G
G
K
D
G
Site 47
S394
I
P
C
R
R
M
R
S
G
S
Y
I
K
A
M
Site 48
S396
C
R
R
M
R
S
G
S
Y
I
K
A
M
G
D
Site 49
S406
K
A
M
G
D
E
E
S
G
D
S
D
G
S
P
Site 50
S409
G
D
E
E
S
G
D
S
D
G
S
P
K
T
S
Site 51
S412
E
S
G
D
S
D
G
S
P
K
T
S
P
K
A
Site 52
T415
D
S
D
G
S
P
K
T
S
P
K
A
V
A
R
Site 53
S416
S
D
G
S
P
K
T
S
P
K
A
V
A
R
R
Site 54
T425
K
A
V
A
R
R
F
T
T
R
R
S
S
S
V
Site 55
T426
A
V
A
R
R
F
T
T
R
R
S
S
S
V
D
Site 56
S429
R
R
F
T
T
R
R
S
S
S
V
D
Q
A
R
Site 57
S430
R
F
T
T
R
R
S
S
S
V
D
Q
A
R
I
Site 58
S431
F
T
T
R
R
S
S
S
V
D
Q
A
R
I
N
Site 59
S449
P
P
R
I
H
P
R
S
S
I
P
G
Y
S
R
Site 60
S450
P
R
I
H
P
R
S
S
I
P
G
Y
S
R
S
Site 61
Y454
P
R
S
S
I
P
G
Y
S
R
S
L
T
T
G
Site 62
S455
R
S
S
I
P
G
Y
S
R
S
L
T
T
G
Q
Site 63
S457
S
I
P
G
Y
S
R
S
L
T
T
G
Q
L
S
Site 64
T459
P
G
Y
S
R
S
L
T
T
G
Q
L
S
D
E
Site 65
S464
S
L
T
T
G
Q
L
S
D
E
L
N
Q
Q
L
Site 66
S500
P
G
C
F
R
M
R
S
H
S
Y
L
R
A
I
Site 67
S502
C
F
R
M
R
S
H
S
Y
L
R
A
I
Q
A
Site 68
Y503
F
R
M
R
S
H
S
Y
L
R
A
I
Q
A
G
Site 69
S512
R
A
I
Q
A
G
C
S
Q
D
D
D
C
L
P
Site 70
S533
A
V
S
G
R
P
G
S
S
F
N
F
R
K
A
Site 71
S534
V
S
G
R
P
G
S
S
F
N
F
R
K
A
P
Site 72
S548
P
P
P
I
P
P
G
S
Q
A
P
P
R
I
S
Site 73
S555
S
Q
A
P
P
R
I
S
I
T
A
Q
S
S
T
Site 74
T557
A
P
P
R
I
S
I
T
A
Q
S
S
T
D
S
Site 75
S560
R
I
S
I
T
A
Q
S
S
T
D
S
A
H
E
Site 76
S561
I
S
I
T
A
Q
S
S
T
D
S
A
H
E
S
Site 77
T562
S
I
T
A
Q
S
S
T
D
S
A
H
E
S
F
Site 78
S564
T
A
Q
S
S
T
D
S
A
H
E
S
F
T
A
Site 79
S568
S
T
D
S
A
H
E
S
F
T
A
A
E
G
P
Site 80
S580
E
G
P
A
R
R
C
S
S
A
D
G
L
D
G
Site 81
S581
G
P
A
R
R
C
S
S
A
D
G
L
D
G
P
Site 82
S605
A
P
V
P
P
R
A
S
P
K
P
P
T
L
I
Site 83
T610
R
A
S
P
K
P
P
T
L
I
I
K
T
I
P
Site 84
T615
P
P
T
L
I
I
K
T
I
P
G
R
E
E
L
Site 85
S624
P
G
R
E
E
L
R
S
L
A
R
Q
R
K
W
Site 86
S634
R
Q
R
K
W
R
P
S
I
G
V
Q
V
E
T
Site 87
T641
S
I
G
V
Q
V
E
T
I
S
D
S
D
T
E
Site 88
S643
G
V
Q
V
E
T
I
S
D
S
D
T
E
N
R
Site 89
S645
Q
V
E
T
I
S
D
S
D
T
E
N
R
S
R
Site 90
T647
E
T
I
S
D
S
D
T
E
N
R
S
R
R
E
Site 91
S651
D
S
D
T
E
N
R
S
R
R
E
F
H
S
I
Site 92
S657
R
S
R
R
E
F
H
S
I
G
V
Q
V
E
E
Site 93
S674
R
R
A
R
F
K
R
S
N
S
V
T
A
G
V
Site 94
S676
A
R
F
K
R
S
N
S
V
T
A
G
V
Q
A
Site 95
T678
F
K
R
S
N
S
V
T
A
G
V
Q
A
D
L
Site 96
T695
E
G
L
A
G
L
A
T
V
A
T
E
D
K
A
Site 97
T698
A
G
L
A
T
V
A
T
E
D
K
A
L
Q
F
Site 98
S708
K
A
L
Q
F
G
R
S
F
Q
R
H
A
S
E
Site 99
S714
R
S
F
Q
R
H
A
S
E
P
Q
P
G
P
R
Site 100
T724
Q
P
G
P
R
A
P
T
Y
S
V
F
R
T
V
Site 101
Y725
P
G
P
R
A
P
T
Y
S
V
F
R
T
V
H
Site 102
S726
G
P
R
A
P
T
Y
S
V
F
R
T
V
H
T
Site 103
Y743
Q
W
A
Y
R
E
G
Y
P
L
P
Y
E
P
P
Site 104
Y747
R
E
G
Y
P
L
P
Y
E
P
P
A
T
D
G
Site 105
T752
L
P
Y
E
P
P
A
T
D
G
S
P
G
P
A
Site 106
S755
E
P
P
A
T
D
G
S
P
G
P
A
P
A
P
Site 107
T763
P
G
P
A
P
A
P
T
P
G
P
G
A
G
R
Site 108
S773
P
G
A
G
R
R
D
S
W
I
E
R
G
S
R
Site 109
S779
D
S
W
I
E
R
G
S
R
S
L
P
D
S
G
Site 110
S781
W
I
E
R
G
S
R
S
L
P
D
S
G
R
A
Site 111
S785
G
S
R
S
L
P
D
S
G
R
A
S
P
C
P
Site 112
S789
L
P
D
S
G
R
A
S
P
C
P
R
D
G
E
Site 113
Y823
M
E
R
E
A
E
D
Y
E
L
P
E
E
I
L
Site 114
S835
E
I
L
E
K
I
R
S
A
V
G
S
T
Q
L
Site 115
S845
G
S
T
Q
L
L
L
S
Q
K
V
Q
Q
F
F
Site 116
T862
C
Q
Q
S
M
D
P
T
A
F
P
V
P
T
F
Site 117
S932
G
V
P
V
K
E
R
S
L
D
S
V
D
R
Q
Site 118
S935
V
K
E
R
S
L
D
S
V
D
R
Q
R
Q
E
Site 119
S955
L
A
A
K
R
A
A
S
F
R
H
S
S
A
T
Site 120
S959
R
A
A
S
F
R
H
S
S
A
T
E
S
A
D
Site 121
S960
A
A
S
F
R
H
S
S
A
T
E
S
A
D
S
Site 122
T962
S
F
R
H
S
S
A
T
E
S
A
D
S
I
E
Site 123
S964
R
H
S
S
A
T
E
S
A
D
S
I
E
I
Y
Site 124
S967
S
A
T
E
S
A
D
S
I
E
I
Y
I
P
E
Site 125
Y971
S
A
D
S
I
E
I
Y
I
P
E
A
Q
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation