KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TTLL1
Full Name:
Probable tubulin polyglutamylase TTLL1
Alias:
C22orf7; Catalytic subunit of neural tubulin polyglutamylase; EC 6.-.-.-; PGs3; Tubulin polyglutamylase; Tubulin polyglutamylase complex 3; Tubulin tyrosine ligase-like family, member 1; Tubulin-tyrosine ligase-like 1
Type:
Ligase; EC 6.-.-.-; Microtubule binding protein; Cell cycle regulation
Mass (Da):
48988
Number AA:
423
UniProt ID:
O95922
International Prot ID:
IsoformA - IPI00302599
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0070740
GO:0004835
PhosphoSite+
KinaseNET
Biological Process:
GO:0018095
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
G
K
V
K
W
V
T
D
I
E
K
S
V
L
Site 2
S57
V
E
A
G
Y
R
L
S
D
D
Q
I
V
N
H
Site 3
S93
K
E
L
E
K
E
G
S
P
L
A
E
K
D
E
Site 4
Y104
E
K
D
E
N
G
K
Y
L
Y
L
D
F
V
P
Site 5
Y106
D
E
N
G
K
Y
L
Y
L
D
F
V
P
V
T
Site 6
S130
F
V
E
E
F
R
K
S
P
S
S
T
W
I
M
Site 7
S133
E
F
R
K
S
P
S
S
T
W
I
M
K
P
C
Site 8
T134
F
R
K
S
P
S
S
T
W
I
M
K
P
C
G
Site 9
S155
I
F
L
I
N
K
L
S
Q
I
K
K
W
S
R
Site 10
S161
L
S
Q
I
K
K
W
S
R
D
S
K
T
S
S
Site 11
S164
I
K
K
W
S
R
D
S
K
T
S
S
F
V
S
Site 12
T166
K
W
S
R
D
S
K
T
S
S
F
V
S
Q
S
Site 13
S167
W
S
R
D
S
K
T
S
S
F
V
S
Q
S
N
Site 14
S168
S
R
D
S
K
T
S
S
F
V
S
Q
S
N
K
Site 15
S171
S
K
T
S
S
F
V
S
Q
S
N
K
E
A
Y
Site 16
Y178
S
Q
S
N
K
E
A
Y
V
I
S
L
Y
I
N
Site 17
Y183
E
A
Y
V
I
S
L
Y
I
N
N
P
L
L
I
Site 18
Y200
R
K
F
D
L
R
L
Y
V
L
V
S
T
Y
R
Site 19
Y206
L
Y
V
L
V
S
T
Y
R
P
L
R
C
Y
M
Site 20
Y212
T
Y
R
P
L
R
C
Y
M
Y
K
L
G
F
C
Site 21
Y214
R
P
L
R
C
Y
M
Y
K
L
G
F
C
R
F
Site 22
Y226
C
R
F
C
T
V
K
Y
T
P
S
T
S
E
L
Site 23
T227
R
F
C
T
V
K
Y
T
P
S
T
S
E
L
D
Site 24
S231
V
K
Y
T
P
S
T
S
E
L
D
N
M
F
V
Site 25
Y252
I
Q
K
H
G
E
D
Y
N
H
I
H
G
G
K
Site 26
T261
H
I
H
G
G
K
W
T
V
S
N
L
R
L
Y
Site 27
S263
H
G
G
K
W
T
V
S
N
L
R
L
Y
L
E
Site 28
Y268
T
V
S
N
L
R
L
Y
L
E
S
T
R
G
K
Site 29
S271
N
L
R
L
Y
L
E
S
T
R
G
K
E
V
T
Site 30
T278
S
T
R
G
K
E
V
T
S
K
L
F
D
E
I
Site 31
S332
I
E
V
N
A
S
P
S
L
T
S
S
T
A
N
Site 32
T334
V
N
A
S
P
S
L
T
S
S
T
A
N
D
R
Site 33
S336
A
S
P
S
L
T
S
S
T
A
N
D
R
I
L
Site 34
Y345
A
N
D
R
I
L
K
Y
N
L
I
N
D
T
L
Site 35
T351
K
Y
N
L
I
N
D
T
L
N
I
A
V
P
N
Site 36
S369
P
D
C
K
W
N
K
S
P
P
K
E
V
L
G
Site 37
Y382
L
G
N
Y
E
I
L
Y
D
E
E
L
A
Q
G
Site 38
S403
L
R
S
R
Q
G
Q
S
L
G
P
R
A
G
R
Site 39
S411
L
G
P
R
A
G
R
S
R
D
S
G
R
A
V
Site 40
S414
R
A
G
R
S
R
D
S
G
R
A
V
L
T
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation