KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TGM6
Full Name:
Protein-glutamine gamma-glutamyltransferase 6
Alias:
DJ734P14.3; EC 2.3.2.13; TGase-3-like; TGM3L; TGY; Transglutaminase 6; Transglutaminase Y; Transglutaminase-3-like
Type:
EC 2.3.2.13; Transferase
Mass (Da):
79312
Number AA:
706
UniProt ID:
O95932
International Prot ID:
IPI00031372
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0005509
GO:0003810
PhosphoSite+
KinaseNET
Biological Process:
GO:0018149
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
A
A
H
H
T
Q
E
Y
P
C
P
E
L
V
V
Site 2
S39
V
R
R
G
Q
S
F
S
L
T
L
E
L
S
R
Site 3
T41
R
G
Q
S
F
S
L
T
L
E
L
S
R
A
L
Site 4
S45
F
S
L
T
L
E
L
S
R
A
L
D
C
E
E
Site 5
S65
M
E
T
G
P
R
A
S
E
A
L
H
T
K
A
Site 6
T70
R
A
S
E
A
L
H
T
K
A
V
F
Q
T
S
Site 7
S77
T
K
A
V
F
Q
T
S
E
L
E
R
G
E
G
Site 8
T86
L
E
R
G
E
G
W
T
A
A
R
E
A
Q
M
Site 9
T96
R
E
A
Q
M
E
K
T
L
T
V
S
L
A
S
Site 10
T98
A
Q
M
E
K
T
L
T
V
S
L
A
S
P
P
Site 11
S100
M
E
K
T
L
T
V
S
L
A
S
P
P
S
A
Site 12
S115
V
I
G
R
Y
L
L
S
I
R
L
S
S
H
R
Site 13
S119
Y
L
L
S
I
R
L
S
S
H
R
K
H
S
N
Site 14
S120
L
L
S
I
R
L
S
S
H
R
K
H
S
N
R
Site 15
S125
L
S
S
H
R
K
H
S
N
R
R
L
G
E
F
Site 16
S149
E
D
D
V
F
L
A
S
E
E
E
R
Q
E
Y
Site 17
Y156
S
E
E
E
R
Q
E
Y
V
L
S
D
S
G
I
Site 18
S159
E
R
Q
E
Y
V
L
S
D
S
G
I
I
F
R
Site 19
S197
C
L
S
I
L
D
R
S
P
G
H
Q
N
N
P
Site 20
Y216
S
C
R
H
N
P
I
Y
V
T
R
V
I
S
A
Site 21
Y242
Q
G
Q
W
Q
G
K
Y
G
G
G
T
S
P
L
Site 22
S247
G
K
Y
G
G
G
T
S
P
L
H
W
R
G
S
Site 23
S254
S
P
L
H
W
R
G
S
V
A
I
L
Q
K
W
Site 24
Y271
G
R
Y
K
P
V
K
Y
G
Q
C
W
V
F
A
Site 25
S296
G
I
A
T
R
V
V
S
N
F
N
S
A
H
D
Site 26
S300
R
V
V
S
N
F
N
S
A
H
D
T
D
Q
N
Site 27
T304
N
F
N
S
A
H
D
T
D
Q
N
L
S
V
D
Site 28
S309
H
D
T
D
Q
N
L
S
V
D
K
Y
V
D
S
Site 29
Y313
Q
N
L
S
V
D
K
Y
V
D
S
F
G
R
T
Site 30
S316
S
V
D
K
Y
V
D
S
F
G
R
T
L
E
D
Site 31
T320
Y
V
D
S
F
G
R
T
L
E
D
L
T
E
D
Site 32
T325
G
R
T
L
E
D
L
T
E
D
S
M
W
N
F
Site 33
Y349
R
Q
D
L
G
P
S
Y
N
G
W
Q
V
L
D
Site 34
T358
G
W
Q
V
L
D
A
T
P
Q
E
E
S
E
G
Site 35
S363
D
A
T
P
Q
E
E
S
E
G
V
F
R
C
G
Site 36
Y414
D
E
S
R
E
R
V
Y
S
N
T
K
K
I
G
Site 37
S415
E
S
R
E
R
V
Y
S
N
T
K
K
I
G
R
Site 38
T417
R
E
R
V
Y
S
N
T
K
K
I
G
R
C
I
Site 39
S425
K
K
I
G
R
C
I
S
T
K
A
V
G
S
D
Site 40
T426
K
I
G
R
C
I
S
T
K
A
V
G
S
D
S
Site 41
S433
T
K
A
V
G
S
D
S
R
V
D
I
T
D
L
Site 42
T438
S
D
S
R
V
D
I
T
D
L
Y
K
Y
P
E
Site 43
Y441
R
V
D
I
T
D
L
Y
K
Y
P
E
G
S
R
Site 44
Y443
D
I
T
D
L
Y
K
Y
P
E
G
S
R
K
E
Site 45
Y454
S
R
K
E
R
Q
V
Y
S
K
A
V
N
R
L
Site 46
S455
R
K
E
R
Q
V
Y
S
K
A
V
N
R
L
F
Site 47
S467
R
L
F
G
V
E
A
S
G
R
R
I
W
I
R
Site 48
T491
D
D
L
L
E
P
A
T
K
P
S
I
A
G
K
Site 49
T566
E
E
K
R
I
P
I
T
I
S
Y
S
K
Y
K
Site 50
S568
K
R
I
P
I
T
I
S
Y
S
K
Y
K
E
D
Site 51
Y569
R
I
P
I
T
I
S
Y
S
K
Y
K
E
D
L
Site 52
Y572
I
T
I
S
Y
S
K
Y
K
E
D
L
T
E
D
Site 53
T577
S
K
Y
K
E
D
L
T
E
D
K
K
I
L
L
Site 54
T659
Q
L
S
I
D
V
P
T
L
E
P
Q
E
R
A
Site 55
S667
L
E
P
Q
E
R
A
S
V
Q
F
D
I
T
P
Site 56
T673
A
S
V
Q
F
D
I
T
P
S
K
S
G
P
R
Site 57
S677
F
D
I
T
P
S
K
S
G
P
R
Q
L
Q
V
Site 58
S688
Q
L
Q
V
D
L
V
S
P
H
F
P
D
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation