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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EOMES
Full Name:
Eomesodermin homolog
Alias:
TBR2
Type:
Nucleus
Mass (Da):
72594
Number AA:
686
UniProt ID:
O95936
International Prot ID:
IPI00296036
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0002302
GO:0007420
GO:0060706
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
N
L
P
G
A
H
F
Y
P
L
E
S
A
R
G
Site 2
S24
A
H
F
Y
P
L
E
S
A
R
G
G
S
G
G
Site 3
S29
L
E
S
A
R
G
G
S
G
G
S
A
G
H
L
Site 4
S32
A
R
G
G
S
G
G
S
A
G
H
L
P
S
A
Site 5
S38
G
S
A
G
H
L
P
S
A
A
P
S
P
Q
K
Site 6
S42
H
L
P
S
A
A
P
S
P
Q
K
L
D
L
D
Site 7
S52
K
L
D
L
D
K
A
S
K
K
F
S
G
S
L
Site 8
S56
D
K
A
S
K
K
F
S
G
S
L
S
C
E
A
Site 9
S58
A
S
K
K
F
S
G
S
L
S
C
E
A
V
S
Site 10
S60
K
K
F
S
G
S
L
S
C
E
A
V
S
G
E
Site 11
S81
G
A
P
A
A
M
L
S
D
T
D
A
G
D
A
Site 12
S107
P
P
D
G
R
K
G
S
P
C
G
E
E
E
L
Site 13
Y134
A
A
A
A
T
A
R
Y
S
M
D
S
L
S
S
Site 14
S135
A
A
A
T
A
R
Y
S
M
D
S
L
S
S
E
Site 15
S138
T
A
R
Y
S
M
D
S
L
S
S
E
R
Y
Y
Site 16
S140
R
Y
S
M
D
S
L
S
S
E
R
Y
Y
L
Q
Site 17
S141
Y
S
M
D
S
L
S
S
E
R
Y
Y
L
Q
S
Site 18
Y144
D
S
L
S
S
E
R
Y
Y
L
Q
S
P
G
P
Site 19
Y145
S
L
S
S
E
R
Y
Y
L
Q
S
P
G
P
Q
Site 20
S148
S
E
R
Y
Y
L
Q
S
P
G
P
Q
G
S
E
Site 21
S154
Q
S
P
G
P
Q
G
S
E
L
A
A
P
C
S
Site 22
Y177
G
A
P
H
G
P
V
Y
P
A
P
N
G
A
R
Site 23
Y185
P
A
P
N
G
A
R
Y
P
Y
G
S
M
L
P
Site 24
Y187
P
N
G
A
R
Y
P
Y
G
S
M
L
P
P
G
Site 25
S189
G
A
R
Y
P
Y
G
S
M
L
P
P
G
G
F
Site 26
S216
G
P
G
A
G
A
G
S
G
A
G
G
S
S
G
Site 27
S221
A
G
S
G
A
G
G
S
S
G
G
G
G
G
P
Site 28
S222
G
S
G
A
G
G
S
S
G
G
G
G
G
P
G
Site 29
T230
G
G
G
G
G
P
G
T
Y
Q
Y
S
Q
G
A
Site 30
Y231
G
G
G
G
P
G
T
Y
Q
Y
S
Q
G
A
P
Site 31
Y233
G
G
P
G
T
Y
Q
Y
S
Q
G
A
P
L
Y
Site 32
S234
G
P
G
T
Y
Q
Y
S
Q
G
A
P
L
Y
G
Site 33
Y240
Y
S
Q
G
A
P
L
Y
G
P
Y
P
G
A
A
Site 34
Y270
S
G
F
R
A
H
V
Y
L
C
N
R
P
L
W
Site 35
T285
L
K
F
H
R
H
Q
T
E
M
I
I
T
K
Q
Site 36
Y350
N
M
Q
G
N
K
M
Y
V
H
P
E
S
P
N
Site 37
T358
V
H
P
E
S
P
N
T
G
S
H
W
M
R
Q
Site 38
T375
S
F
G
K
L
K
L
T
N
N
K
G
A
N
N
Site 39
T385
K
G
A
N
N
N
N
T
Q
M
I
V
L
Q
S
Site 40
Y396
V
L
Q
S
L
H
K
Y
Q
P
R
L
H
I
V
Site 41
T419
D
L
N
E
P
S
K
T
Q
T
F
T
F
S
E
Site 42
T421
N
E
P
S
K
T
Q
T
F
T
F
S
E
T
Q
Site 43
T423
P
S
K
T
Q
T
F
T
F
S
E
T
Q
F
I
Site 44
S425
K
T
Q
T
F
T
F
S
E
T
Q
F
I
A
V
Site 45
T441
A
Y
Q
N
T
D
I
T
Q
L
K
I
D
H
N
Site 46
Y458
A
K
G
F
R
D
N
Y
D
S
S
H
Q
I
V
Site 47
S460
G
F
R
D
N
Y
D
S
S
H
Q
I
V
P
G
Site 48
S461
F
R
D
N
Y
D
S
S
H
Q
I
V
P
G
G
Site 49
Y470
Q
I
V
P
G
G
R
Y
G
V
Q
S
F
F
P
Site 50
S474
G
G
R
Y
G
V
Q
S
F
F
P
E
P
F
V
Site 51
Y489
N
T
L
P
Q
A
R
Y
Y
N
G
E
R
T
V
Site 52
Y490
T
L
P
Q
A
R
Y
Y
N
G
E
R
T
V
P
Site 53
T495
R
Y
Y
N
G
E
R
T
V
P
Q
T
N
G
L
Site 54
T499
G
E
R
T
V
P
Q
T
N
G
L
L
S
P
Q
Site 55
S504
P
Q
T
N
G
L
L
S
P
Q
Q
S
E
E
V
Site 56
S508
G
L
L
S
P
Q
Q
S
E
E
V
A
N
P
P
Site 57
T521
P
P
Q
R
W
L
V
T
P
V
Q
Q
P
G
T
Site 58
S534
G
T
N
K
L
D
I
S
S
Y
E
S
E
Y
T
Site 59
S535
T
N
K
L
D
I
S
S
Y
E
S
E
Y
T
S
Site 60
Y536
N
K
L
D
I
S
S
Y
E
S
E
Y
T
S
S
Site 61
S538
L
D
I
S
S
Y
E
S
E
Y
T
S
S
T
L
Site 62
Y540
I
S
S
Y
E
S
E
Y
T
S
S
T
L
L
P
Site 63
T541
S
S
Y
E
S
E
Y
T
S
S
T
L
L
P
Y
Site 64
S542
S
Y
E
S
E
Y
T
S
S
T
L
L
P
Y
G
Site 65
S543
Y
E
S
E
Y
T
S
S
T
L
L
P
Y
G
I
Site 66
T544
E
S
E
Y
T
S
S
T
L
L
P
Y
G
I
K
Site 67
S552
L
L
P
Y
G
I
K
S
L
P
L
Q
T
S
H
Site 68
S558
K
S
L
P
L
Q
T
S
H
A
L
G
Y
Y
P
Site 69
Y564
T
S
H
A
L
G
Y
Y
P
D
P
T
F
P
A
Site 70
S580
A
G
W
G
G
R
G
S
Y
Q
R
K
M
A
A
Site 71
Y581
G
W
G
G
R
G
S
Y
Q
R
K
M
A
A
G
Site 72
T592
M
A
A
G
L
P
W
T
S
R
T
S
P
T
V
Site 73
S593
A
A
G
L
P
W
T
S
R
T
S
P
T
V
F
Site 74
S596
L
P
W
T
S
R
T
S
P
T
V
F
S
E
D
Site 75
S601
R
T
S
P
T
V
F
S
E
D
Q
L
S
K
E
Site 76
S606
V
F
S
E
D
Q
L
S
K
E
K
V
K
E
E
Site 77
S616
K
V
K
E
E
I
G
S
S
W
I
E
T
P
P
Site 78
S617
V
K
E
E
I
G
S
S
W
I
E
T
P
P
S
Site 79
T621
I
G
S
S
W
I
E
T
P
P
S
I
K
S
L
Site 80
S624
S
W
I
E
T
P
P
S
I
K
S
L
D
S
N
Site 81
S627
E
T
P
P
S
I
K
S
L
D
S
N
D
S
G
Site 82
S630
P
S
I
K
S
L
D
S
N
D
S
G
V
Y
T
Site 83
S633
K
S
L
D
S
N
D
S
G
V
Y
T
S
A
C
Site 84
T637
S
N
D
S
G
V
Y
T
S
A
C
K
R
R
R
Site 85
S638
N
D
S
G
V
Y
T
S
A
C
K
R
R
R
L
Site 86
S646
A
C
K
R
R
R
L
S
P
S
N
S
S
N
E
Site 87
S648
K
R
R
R
L
S
P
S
N
S
S
N
E
N
S
Site 88
S650
R
R
L
S
P
S
N
S
S
N
E
N
S
P
S
Site 89
S651
R
L
S
P
S
N
S
S
N
E
N
S
P
S
I
Site 90
S655
S
N
S
S
N
E
N
S
P
S
I
K
C
E
D
Site 91
S657
S
S
N
E
N
S
P
S
I
K
C
E
D
I
N
Site 92
S673
E
E
Y
S
K
D
T
S
K
G
M
G
G
Y
Y
Site 93
Y680
S
K
G
M
G
G
Y
Y
A
F
Y
T
T
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation