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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LDH-A
Full Name:
L-lactate dehydrogenase A chain
Alias:
Lactate dehydrogenase A; LDH muscle subunit; LDHA; LDH-M
Type:
Oxidoreductase; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Apoptosis
Mass (Da):
36689
Number AA:
332
UniProt ID:
P00338
International Prot ID:
IPI00217966
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004459
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019642
GO:0055114
GO:0006090
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
T
L
K
D
Q
L
I
Y
N
L
L
K
E
E
Q
Site 2
T18
N
L
L
K
E
E
Q
T
P
Q
N
K
I
T
V
Site 3
S38
V
G
M
A
C
A
I
S
I
L
M
K
D
L
A
Site 4
S69
M
M
D
L
Q
H
G
S
L
F
L
R
T
P
K
Site 5
T74
H
G
S
L
F
L
R
T
P
K
I
V
S
G
K
Site 6
Y83
K
I
V
S
G
K
D
Y
N
V
T
A
N
S
K
Site 7
Y127
I
I
P
N
V
V
K
Y
S
P
N
C
K
L
L
Site 8
S128
I
P
N
V
V
K
Y
S
P
N
C
K
L
L
I
Site 9
T144
S
N
P
V
D
I
L
T
Y
V
A
W
K
I
S
Site 10
Y145
N
P
V
D
I
L
T
Y
V
A
W
K
I
S
G
Site 11
S161
P
K
N
R
V
I
G
S
G
C
N
L
D
S
A
Site 12
S167
G
S
G
C
N
L
D
S
A
R
F
R
Y
L
M
Site 13
Y172
L
D
S
A
R
F
R
Y
L
M
G
E
R
L
G
Site 14
S196
V
L
G
E
H
G
D
S
S
V
P
V
W
S
G
Site 15
S197
L
G
E
H
G
D
S
S
V
P
V
W
S
G
M
Site 16
S237
V
H
K
Q
V
V
E
S
A
Y
E
V
I
K
L
Site 17
Y239
K
Q
V
V
E
S
A
Y
E
V
I
K
L
K
G
Site 18
T248
V
I
K
L
K
G
Y
T
S
W
A
I
G
L
S
Site 19
S249
I
K
L
K
G
Y
T
S
W
A
I
G
L
S
V
Site 20
T275
R
R
V
H
P
V
S
T
M
I
K
G
L
Y
G
Site 21
Y281
S
T
M
I
K
G
L
Y
G
I
K
D
D
V
F
Site 22
T309
D
L
V
K
V
T
L
T
S
E
E
E
A
R
L
Site 23
S319
E
E
A
R
L
K
K
S
A
D
T
L
W
G
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation