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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MT-CO1
Full Name:
Cytochrome c oxidase subunit 1
Alias:
COI; Cytochrome c oxidase I; Cytochrome c oxidase polypeptide I; Mitochondrially encoded cytochrome c oxidase I; MTCO1
Type:
EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Oxidoreductase
Mass (Da):
57041
Number AA:
513
UniProt ID:
P00395
International Prot ID:
IPI00464968
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005743
GO:0070469
Uniprot
OncoNet
Molecular Function:
GO:0005507
GO:0004129
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0009060
GO:0006123
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
A
D
R
W
L
F
S
T
N
H
K
D
I
G
T
Site 2
T17
T
N
H
K
D
I
G
T
L
Y
L
L
F
G
A
Site 3
Y19
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
Site 4
T31
A
W
A
G
V
L
G
T
A
L
S
L
L
I
R
Site 5
S34
G
V
L
G
T
A
L
S
L
L
I
R
A
E
L
Site 6
Y129
A
G
T
G
W
T
V
Y
P
P
L
A
G
N
Y
Site 7
Y136
Y
P
P
L
A
G
N
Y
S
H
P
G
A
S
V
Site 8
S137
P
P
L
A
G
N
Y
S
H
P
G
A
S
V
D
Site 9
S156
S
L
H
L
A
G
V
S
S
I
L
G
A
I
N
Site 10
S157
L
H
L
A
G
V
S
S
I
L
G
A
I
N
F
Site 11
Y179
K
P
P
A
M
T
Q
Y
Q
T
P
L
F
V
W
Site 12
T218
T
D
R
N
L
N
T
T
F
F
D
P
A
G
G
Site 13
T259
G
M
I
S
H
I
V
T
Y
Y
S
G
K
K
E
Site 14
S262
S
H
I
V
T
Y
Y
S
G
K
K
E
P
F
G
Site 15
Y270
G
K
K
E
P
F
G
Y
M
G
M
V
W
A
M
Site 16
T301
T
V
G
M
D
V
D
T
R
A
Y
F
T
S
A
Site 17
Y304
M
D
V
D
T
R
A
Y
F
T
S
A
T
M
I
Site 18
T316
T
M
I
I
A
I
P
T
G
V
K
V
F
S
W
Site 19
T326
K
V
F
S
W
L
A
T
L
H
G
S
N
M
K
Site 20
S330
W
L
A
T
L
H
G
S
N
M
K
W
S
A
A
Site 21
T408
S
G
Y
T
L
D
Q
T
Y
A
K
I
H
F
T
Site 22
Y409
G
Y
T
L
D
Q
T
Y
A
K
I
H
F
T
I
Site 23
S434
P
Q
H
F
L
G
L
S
G
M
P
R
R
Y
S
Site 24
Y440
L
S
G
M
P
R
R
Y
S
D
Y
P
D
A
Y
Site 25
S441
S
G
M
P
R
R
Y
S
D
Y
P
D
A
Y
T
Site 26
Y443
M
P
R
R
Y
S
D
Y
P
D
A
Y
T
T
W
Site 27
Y447
Y
S
D
Y
P
D
A
Y
T
T
W
N
I
L
S
Site 28
T448
S
D
Y
P
D
A
Y
T
T
W
N
I
L
S
S
Site 29
Y496
S
M
N
L
E
W
L
Y
G
C
P
P
P
Y
H
Site 30
Y502
L
Y
G
C
P
P
P
Y
H
T
F
E
E
P
V
Site 31
T504
G
C
P
P
P
Y
H
T
F
E
E
P
V
Y
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation