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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAH (Phenylalanine Hydroxylase)
Full Name:
Phenylalanine-4-hydroxylase
Alias:
Phe-4-monooxygenase
Type:
Enzyme
Mass (Da):
51862
Number AA:
452
UniProt ID:
P00439
International Prot ID:
IPI00017579
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016597
GO:0005506
GO:0004505
PhosphoSite+
KinaseNET
Biological Process:
GO:0006559
GO:0042423
GO:0042136
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
T
A
V
L
E
N
P
Site 2
T3
_
_
_
_
_
M
S
T
A
V
L
E
N
P
G
Site 3
S16
P
G
L
G
R
K
L
S
D
F
G
Q
E
T
S
Site 4
Y24
D
F
G
Q
E
T
S
Y
I
E
D
N
C
N
Q
Site 5
T63
E
E
N
D
V
N
L
T
H
I
E
S
R
P
S
Site 6
S70
T
H
I
E
S
R
P
S
R
L
K
K
D
E
Y
Site 7
Y77
S
R
L
K
K
D
E
Y
E
F
F
T
H
L
D
Site 8
S87
F
T
H
L
D
K
R
S
L
P
A
L
T
N
I
Site 9
T117
S
R
D
K
K
K
D
T
V
P
W
F
P
R
T
Site 10
S137
R
F
A
N
Q
I
L
S
Y
G
A
E
L
D
A
Site 11
Y154
P
G
F
K
D
P
V
Y
R
A
R
R
K
Q
F
Site 12
Y166
K
Q
F
A
D
I
A
Y
N
Y
R
H
G
Q
P
Site 13
Y168
F
A
D
I
A
Y
N
Y
R
H
G
Q
P
I
P
Site 14
Y179
Q
P
I
P
R
V
E
Y
M
E
E
E
K
K
T
Site 15
T186
Y
M
E
E
E
K
K
T
W
G
T
V
F
K
T
Site 16
T193
T
W
G
T
V
F
K
T
L
K
S
L
Y
K
T
Site 17
S196
T
V
F
K
T
L
K
S
L
Y
K
T
H
A
C
Site 18
T200
T
L
K
S
L
Y
K
T
H
A
C
Y
E
Y
N
Site 19
Y206
K
T
H
A
C
Y
E
Y
N
H
I
F
P
L
L
Site 20
Y216
I
F
P
L
L
E
K
Y
C
G
F
H
E
D
N
Site 21
S231
I
P
Q
L
E
D
V
S
Q
F
L
Q
T
C
T
Site 22
Y268
R
V
F
H
C
T
Q
Y
I
R
H
G
S
K
P
Site 23
S273
T
Q
Y
I
R
H
G
S
K
P
M
Y
T
P
E
Site 24
Y277
R
H
G
S
K
P
M
Y
T
P
E
P
D
I
C
Site 25
T278
H
G
S
K
P
M
Y
T
P
E
P
D
I
C
H
Site 26
S298
V
P
L
F
S
D
R
S
F
A
Q
F
S
Q
E
Site 27
S303
D
R
S
F
A
Q
F
S
Q
E
I
G
L
A
S
Site 28
S310
S
Q
E
I
G
L
A
S
L
G
A
P
D
E
Y
Site 29
Y317
S
L
G
A
P
D
E
Y
I
E
K
L
A
T
I
Site 30
S339
G
L
C
K
Q
G
D
S
I
K
A
Y
G
A
G
Site 31
Y343
Q
G
D
S
I
K
A
Y
G
A
G
L
L
S
S
Site 32
Y356
S
S
F
G
E
L
Q
Y
C
L
S
E
K
P
K
Site 33
S359
G
E
L
Q
Y
C
L
S
E
K
P
K
L
L
P
Site 34
T372
L
P
L
E
L
E
K
T
A
I
Q
N
Y
T
V
Site 35
T378
K
T
A
I
Q
N
Y
T
V
T
E
F
Q
P
L
Site 36
Y386
V
T
E
F
Q
P
L
Y
Y
V
A
E
S
F
N
Site 37
Y387
T
E
F
Q
P
L
Y
Y
V
A
E
S
F
N
D
Site 38
S391
P
L
Y
Y
V
A
E
S
F
N
D
A
K
E
K
Site 39
T405
K
V
R
N
F
A
A
T
I
P
R
P
F
S
V
Site 40
S411
A
T
I
P
R
P
F
S
V
R
Y
D
P
Y
T
Site 41
Y417
F
S
V
R
Y
D
P
Y
T
Q
R
I
E
V
L
Site 42
T418
S
V
R
Y
D
P
Y
T
Q
R
I
E
V
L
D
Site 43
T427
R
I
E
V
L
D
N
T
Q
Q
L
K
I
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation