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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CP
Full Name:
Ceruloplasmin
Alias:
CERU; Ceruloplasmin (ferroxidase); EC 1.16.3.1; Ferroxidase
Type:
Membrane protein, anchored; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase
Mass (Da):
122205
Number AA:
1056
UniProt ID:
P00450
International Prot ID:
IPI00017601
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005507
GO:0004322
PhosphoSite+
KinaseNET
Biological Process:
GO:0006879
GO:0006825
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
W
A
K
E
K
H
Y
Y
I
G
I
I
E
T
T
Site 2
Y35
I
I
E
T
T
W
D
Y
A
S
D
H
G
E
K
Site 3
S37
E
T
T
W
D
Y
A
S
D
H
G
E
K
K
L
Site 4
S46
H
G
E
K
K
L
I
S
V
D
T
E
H
S
N
Site 5
Y55
D
T
E
H
S
N
I
Y
L
Q
N
G
P
D
R
Site 6
Y67
P
D
R
I
G
R
L
Y
K
K
A
L
Y
L
Q
Site 7
Y72
R
L
Y
K
K
A
L
Y
L
Q
Y
T
D
E
T
Site 8
T76
K
A
L
Y
L
Q
Y
T
D
E
T
F
R
T
T
Site 9
T79
Y
L
Q
Y
T
D
E
T
F
R
T
T
I
E
K
Site 10
T82
Y
T
D
E
T
F
R
T
T
I
E
K
P
V
W
Site 11
T83
T
D
E
T
F
R
T
T
I
E
K
P
V
W
L
Site 12
Y106
A
E
T
G
D
K
V
Y
V
H
L
K
N
L
A
Site 13
S114
V
H
L
K
N
L
A
S
R
P
Y
T
F
H
S
Site 14
Y117
K
N
L
A
S
R
P
Y
T
F
H
S
H
G
I
Site 15
T118
N
L
A
S
R
P
Y
T
F
H
S
H
G
I
T
Site 16
T125
T
F
H
S
H
G
I
T
Y
Y
K
E
H
E
G
Site 17
Y127
H
S
H
G
I
T
Y
Y
K
E
H
E
G
A
I
Site 18
Y135
K
E
H
E
G
A
I
Y
P
D
N
T
T
D
F
Site 19
T139
G
A
I
Y
P
D
N
T
T
D
F
Q
R
A
D
Site 20
Y150
Q
R
A
D
D
K
V
Y
P
G
E
Q
Y
T
Y
Site 21
Y157
Y
P
G
E
Q
Y
T
Y
M
L
L
A
T
E
E
Site 22
T162
Y
T
Y
M
L
L
A
T
E
E
Q
S
P
G
E
Site 23
S166
L
L
A
T
E
E
Q
S
P
G
E
G
D
G
N
Site 24
Y179
G
N
C
V
T
R
I
Y
H
S
H
I
D
A
P
Site 25
S204
L
I
I
C
K
K
D
S
L
D
K
E
K
E
K
Site 26
Y231
V
D
E
N
F
S
W
Y
L
E
D
N
I
K
T
Site 27
T238
Y
L
E
D
N
I
K
T
Y
C
S
E
P
E
K
Site 28
Y260
F
Q
E
S
N
R
M
Y
S
V
N
G
Y
T
F
Site 29
S261
Q
E
S
N
R
M
Y
S
V
N
G
Y
T
F
G
Site 30
Y265
R
M
Y
S
V
N
G
Y
T
F
G
S
L
P
G
Site 31
Y284
A
E
D
R
V
K
W
Y
L
F
G
M
G
N
E
Site 32
T313
N
K
N
Y
R
I
D
T
I
N
L
F
P
A
T
Site 33
S360
Q
V
Q
E
C
N
K
S
S
S
K
D
N
I
R
Site 34
S362
Q
E
C
N
K
S
S
S
K
D
N
I
R
G
K
Site 35
Y374
R
G
K
H
V
R
H
Y
Y
I
A
A
E
E
I
Site 36
Y375
G
K
H
V
R
H
Y
Y
I
A
A
E
E
I
I
Site 37
T394
P
S
G
I
D
I
F
T
K
E
N
L
T
A
P
Site 38
T399
I
F
T
K
E
N
L
T
A
P
G
S
D
S
A
Site 39
S403
E
N
L
T
A
P
G
S
D
S
A
V
F
F
E
Site 40
S405
L
T
A
P
G
S
D
S
A
V
F
F
E
Q
G
Site 41
T413
A
V
F
F
E
Q
G
T
T
R
I
G
G
S
Y
Site 42
T414
V
F
F
E
Q
G
T
T
R
I
G
G
S
Y
K
Site 43
S419
G
T
T
R
I
G
G
S
Y
K
K
L
V
Y
R
Site 44
Y420
T
T
R
I
G
G
S
Y
K
K
L
V
Y
R
E
Site 45
Y428
K
K
L
V
Y
R
E
Y
T
D
A
S
F
T
N
Site 46
T429
K
L
V
Y
R
E
Y
T
D
A
S
F
T
N
R
Site 47
S432
Y
R
E
Y
T
D
A
S
F
T
N
R
K
E
R
Site 48
T464
V
G
D
T
I
R
V
T
F
H
N
K
G
A
Y
Site 49
Y471
T
F
H
N
K
G
A
Y
P
L
S
I
E
P
I
Site 50
S474
N
K
G
A
Y
P
L
S
I
E
P
I
G
V
R
Site 51
Y490
N
K
N
N
E
G
T
Y
Y
S
P
N
Y
N
P
Site 52
Y491
K
N
N
E
G
T
Y
Y
S
P
N
Y
N
P
Q
Site 53
S492
N
N
E
G
T
Y
Y
S
P
N
Y
N
P
Q
S
Site 54
Y495
G
T
Y
Y
S
P
N
Y
N
P
Q
S
R
S
V
Site 55
S499
S
P
N
Y
N
P
Q
S
R
S
V
P
P
S
A
Site 56
S501
N
Y
N
P
Q
S
R
S
V
P
P
S
A
S
H
Site 57
S505
Q
S
R
S
V
P
P
S
A
S
H
V
A
P
T
Site 58
S507
R
S
V
P
P
S
A
S
H
V
A
P
T
E
T
Site 59
T514
S
H
V
A
P
T
E
T
F
T
Y
E
W
T
V
Site 60
Y517
A
P
T
E
T
F
T
Y
E
W
T
V
P
K
E
Site 61
T520
E
T
F
T
Y
E
W
T
V
P
K
E
V
G
P
Site 62
Y539
P
V
C
L
A
K
M
Y
Y
S
A
V
D
P
T
Site 63
T546
Y
Y
S
A
V
D
P
T
K
D
I
F
T
G
L
Site 64
T551
D
P
T
K
D
I
F
T
G
L
I
G
P
M
K
Site 65
Y579
K
D
V
D
K
E
F
Y
L
F
P
T
V
F
D
Site 66
T583
K
E
F
Y
L
F
P
T
V
F
D
E
N
E
S
Site 67
T601
E
D
N
I
R
M
F
T
T
A
P
D
Q
V
D
Site 68
Y628
H
S
M
N
G
F
M
Y
G
N
Q
P
G
L
T
Site 69
T635
Y
G
N
Q
P
G
L
T
M
C
K
G
D
S
V
Site 70
Y645
K
G
D
S
V
V
W
Y
L
F
S
A
G
N
E
Site 71
Y659
E
A
D
V
H
G
I
Y
F
S
G
N
T
Y
L
Site 72
Y665
I
Y
F
S
G
N
T
Y
L
W
R
G
E
R
R
Site 73
T674
W
R
G
E
R
R
D
T
A
N
L
F
P
Q
T
Site 74
T684
L
F
P
Q
T
S
L
T
L
H
M
W
P
D
T
Site 75
T691
T
L
H
M
W
P
D
T
E
G
T
F
N
V
E
Site 76
Y705
E
C
L
T
T
D
H
Y
T
G
G
M
K
Q
K
Site 77
Y713
T
G
G
M
K
Q
K
Y
T
V
N
Q
C
R
R
Site 78
S722
V
N
Q
C
R
R
Q
S
E
D
S
T
F
Y
L
Site 79
S725
C
R
R
Q
S
E
D
S
T
F
Y
L
G
E
R
Site 80
T726
R
R
Q
S
E
D
S
T
F
Y
L
G
E
R
T
Site 81
Y728
Q
S
E
D
S
T
F
Y
L
G
E
R
T
Y
Y
Site 82
Y735
Y
L
G
E
R
T
Y
Y
I
A
A
V
E
V
E
Site 83
Y745
A
V
E
V
E
W
D
Y
S
P
Q
R
E
W
E
Site 84
S746
V
E
V
E
W
D
Y
S
P
Q
R
E
W
E
K
Site 85
S764
H
L
Q
E
Q
N
V
S
N
A
F
L
D
K
G
Site 86
Y779
E
F
Y
I
G
S
K
Y
K
K
V
V
Y
R
Q
Site 87
Y784
S
K
Y
K
K
V
V
Y
R
Q
Y
T
D
S
T
Site 88
Y787
K
K
V
V
Y
R
Q
Y
T
D
S
T
F
R
V
Site 89
T788
K
V
V
Y
R
Q
Y
T
D
S
T
F
R
V
P
Site 90
S790
V
Y
R
Q
Y
T
D
S
T
F
R
V
P
V
E
Site 91
T791
Y
R
Q
Y
T
D
S
T
F
R
V
P
V
E
R
Site 92
Y832
K
N
M
A
T
R
P
Y
S
I
H
A
H
G
V
Site 93
S843
A
H
G
V
Q
T
E
S
S
T
V
T
P
T
L
Site 94
S844
H
G
V
Q
T
E
S
S
T
V
T
P
T
L
P
Site 95
T845
G
V
Q
T
E
S
S
T
V
T
P
T
L
P
G
Site 96
T847
Q
T
E
S
S
T
V
T
P
T
L
P
G
E
T
Site 97
T849
E
S
S
T
V
T
P
T
L
P
G
E
T
L
T
Site 98
Y857
L
P
G
E
T
L
T
Y
V
W
K
I
P
E
R
Site 99
T869
P
E
R
S
G
A
G
T
E
D
S
A
C
I
P
Site 100
S872
S
G
A
G
T
E
D
S
A
C
I
P
W
A
Y
Site 101
Y904
L
I
V
C
R
R
P
Y
L
K
V
F
N
P
R
Site 102
Y930
F
D
E
N
E
S
W
Y
L
D
D
N
I
K
T
Site 103
T937
Y
L
D
D
N
I
K
T
Y
S
D
H
P
E
K
Site 104
S939
D
D
N
I
K
T
Y
S
D
H
P
E
K
V
N
Site 105
Y983
V
G
D
E
V
N
W
Y
L
M
G
M
G
N
E
Site 106
T995
G
N
E
I
D
L
H
T
V
H
F
H
G
H
S
Site 107
Y1005
F
H
G
H
S
F
Q
Y
K
H
R
G
V
Y
S
Site 108
Y1011
Q
Y
K
H
R
G
V
Y
S
S
D
V
F
D
I
Site 109
S1013
K
H
R
G
V
Y
S
S
D
V
F
D
I
F
P
Site 110
T1055
A
G
M
E
T
T
Y
T
V
L
Q
N
E
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation