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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GOT2
Full Name:
Aspartate aminotransferase, mitochondrial
Alias:
AATM; Aspartate aminotransferase 2; Aspartate aminotransferase, mitochondrial; Glutamate oxaloacetate transaminase 2; Glutamic-oxaloacetic transaminase 2, mitochondrial; KAT4; KATIV; Kynurenine aminotransferase IV; MitAAT; Transaminase A
Type:
Amino Acid Metabolism - arginine and proline; Transferase; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.1
Mass (Da):
47476
Number AA:
430
UniProt ID:
P00505
International Prot ID:
IPI00018206
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004069
GO:0030170
PhosphoSite+
KinaseNET
Biological Process:
GO:0006533
GO:0015908
GO:0045471
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
A
A
A
S
A
R
A
S
S
W
W
T
H
V
E
Site 2
S31
A
A
S
A
R
A
S
S
W
W
T
H
V
E
M
Site 3
T34
A
R
A
S
S
W
W
T
H
V
E
M
G
P
P
Site 4
T55
T
E
A
F
K
R
D
T
N
S
K
K
M
N
L
Site 5
S57
A
F
K
R
D
T
N
S
K
K
M
N
L
G
V
Site 6
Y67
M
N
L
G
V
G
A
Y
R
D
D
N
G
K
P
Site 7
Y75
R
D
D
N
G
K
P
Y
V
L
P
S
V
R
K
Site 8
S79
G
K
P
Y
V
L
P
S
V
R
K
A
E
A
Q
Site 9
Y96
A
K
N
L
D
K
E
Y
L
P
I
G
G
L
A
Site 10
S118
E
L
A
L
G
E
N
S
E
V
L
K
S
G
R
Site 11
S123
E
N
S
E
V
L
K
S
G
R
F
V
T
V
Q
Site 12
T128
L
K
S
G
R
F
V
T
V
Q
T
I
S
G
T
Site 13
S133
F
V
T
V
Q
T
I
S
G
T
G
A
L
R
I
Site 14
T135
T
V
Q
T
I
S
G
T
G
A
L
R
I
G
A
Site 15
S143
G
A
L
R
I
G
A
S
F
L
Q
R
F
F
K
Site 16
S152
L
Q
R
F
F
K
F
S
R
D
V
F
L
P
K
Site 17
T161
D
V
F
L
P
K
P
T
W
G
N
H
T
P
I
Site 18
T166
K
P
T
W
G
N
H
T
P
I
F
R
D
A
G
Site 19
Y179
A
G
M
Q
L
Q
G
Y
R
Y
Y
D
P
K
T
Site 20
Y181
M
Q
L
Q
G
Y
R
Y
Y
D
P
K
T
C
G
Site 21
Y182
Q
L
Q
G
Y
R
Y
Y
D
P
K
T
C
G
F
Site 22
T192
K
T
C
G
F
D
F
T
G
A
V
E
D
I
S
Site 23
S199
T
G
A
V
E
D
I
S
K
I
P
E
Q
S
V
Site 24
Y284
Y
A
K
N
M
G
L
Y
G
E
R
V
G
A
F
Site 25
T292
G
E
R
V
G
A
F
T
M
V
C
K
D
A
D
Site 26
S306
D
E
A
K
R
V
E
S
Q
L
K
I
L
I
R
Site 27
Y316
K
I
L
I
R
P
M
Y
S
N
P
P
L
N
G
Site 28
T333
I
A
A
A
I
L
N
T
P
D
L
R
K
Q
W
Site 29
T356
D
R
I
I
G
M
R
T
Q
L
V
S
N
L
K
Site 30
S360
G
M
R
T
Q
L
V
S
N
L
K
K
E
G
S
Site 31
S399
E
R
L
I
K
E
F
S
I
Y
M
T
K
D
G
Site 32
Y401
L
I
K
E
F
S
I
Y
M
T
K
D
G
R
I
Site 33
T403
K
E
F
S
I
Y
M
T
K
D
G
R
I
S
V
Site 34
S409
M
T
K
D
G
R
I
S
V
A
G
V
T
S
S
Site 35
T414
R
I
S
V
A
G
V
T
S
S
N
V
G
Y
L
Site 36
S415
I
S
V
A
G
V
T
S
S
N
V
G
Y
L
A
Site 37
S416
S
V
A
G
V
T
S
S
N
V
G
Y
L
A
H
Site 38
Y420
V
T
S
S
N
V
G
Y
L
A
H
A
I
H
Q
Site 39
T429
A
H
A
I
H
Q
V
T
K
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation