PhosphoNET

           
Protein Info 
   
Short Name:  EGF receptor
Full Name:  Epidermal growth factor receptor
Alias:  EC 2.7.10.1; EGFR; Epidermal growth factor receptor; ErbB-1; Receptor tyrosine-protein kinase ErbB-1; V-erb-b oncogene homologue
Type:  Protein-tyrosine kinase (receptor), TK group, EGFR family
Mass (Da):  134277
Number AA:  1210
UniProt ID:  P00533
International Prot ID:  IPI00018274
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0070435  GO:0016323  GO:0005768 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004710  GO:0051015 PhosphoSite+ KinaseNET
Biological Process:  GO:0043006  GO:0007202  GO:0008283 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y112QIIRGNMYYENSYAL
Site 2Y113IIRGNMYYENSYALA
Site 3Y117NMYYENSYALAVLSN
Site 4S151LHGAVRFSNNPALCN
Site 5S229RCRGKSPSDCCHNQC
Site 6Y270TCPPLMLYNPTTYQM
Site 7Y316RACGADSYEMEEDGV
Site 8S511QVCHALCSPEGCWGP
Site 9Y585NCIQCAHYIDGPHCV
Site 10S645TNGPKIPSIATGMVG
Site 11T648PKIPSIATGMVGALL
Site 12T678RHIVRKRTLRRLLQE
Site 13T693RELVEPLTPSGEAPN
Site 14S695LVEPLTPSGEAPNQA
Site 15T710LLRILKETEFKKIKV
Site 16S720KKIKVLGSGAFGTVY
Site 17T725LGSGAFGTVYKGLWI
Site 18Y727SGAFGTVYKGLWIPE
Site 19T751IKELREATSPKANKE
Site 20S752KELREATSPKANKEI
Site 21Y764KEILDEAYVMASVDN
Site 22S768DEAYVMASVDNPHVC
Site 23Y801PFGCLLDYVREHKDN
Site 24Y813KDNIGSQYLLNWCVQ
Site 25Y827QIAKGMNYLEDRRLV
Site 26T847ARNVLVKTPQHVKIT
Site 27Y869LGAEEKEYHAEGGKV
Site 28Y891ESILHRIYTHQSDVW
Site 29T892SILHRIYTHQSDVWS
Site 30T909VTVWELMTFGSKPYD
Site 31Y915MTFGSKPYDGIPASE
Site 32S921PYDGIPASEISSILE
Site 33S925IPASEISSILEKGER
Site 34T940LPQPPICTIDVYMIM
Site 35Y944PICTIDVYMIMVKCW
Site 36Y978MARDPQRYLVIQGDE
Site 37S991DERMHLPSPTDSNFY
Site 38T993RMHLPSPTDSNFYRA
Site 39S995HLPSPTDSNFYRALM
Site 40Y998SPTDSNFYRALMDEE
Site 41Y1016DVVDADEYLIPQQGF
Site 42S1025IPQQGFFSSPSTSRT
Site 43S1026PQQGFFSSPSTSRTP
Site 44S1028QGFFSSPSTSRTPLL
Site 45T1029GFFSSPSTSRTPLLS
Site 46S1030FFSSPSTSRTPLLSS
Site 47T1032SSPSTSRTPLLSSLS
Site 48S1036TSRTPLLSSLSATSN
Site 49S1037SRTPLLSSLSATSNN
Site 50S1039TPLLSSLSATSNNST
Site 51T1041LLSSLSATSNNSTVA
Site 52S1042LSSLSATSNNSTVAC
Site 53S1045LSATSNNSTVACIDR
Site 54T1046SATSNNSTVACIDRN
Site 55S1057IDRNGLQSCPIKEDS
Site 56S1064SCPIKEDSFLQRYSS
Site 57Y1069EDSFLQRYSSDPTGA
Site 58S1070DSFLQRYSSDPTGAL
Site 59S1071SFLQRYSSDPTGALT
Site 60T1074QRYSSDPTGALTEDS
Site 61T1078SDPTGALTEDSIDDT
Site 62S1081TGALTEDSIDDTFLP
Site 63T1085TEDSIDDTFLPVPEY
Site 64Y1092TFLPVPEYINQSVPK
Site 65S1096VPEYINQSVPKRPAG
Site 66S1104VPKRPAGSVQNPVYH
Site 67Y1110GSVQNPVYHNQPLNP
Site 68S1120QPLNPAPSRDPHYQD
Site 69Y1125APSRDPHYQDPHSTA
Site 70S1130PHYQDPHSTAVGNPE
Site 71T1131HYQDPHSTAVGNPEY
Site 72Y1138TAVGNPEYLNTVQPT
Site 73T1141GNPEYLNTVQPTCVN
Site 74T1145YLNTVQPTCVNSTFD
Site 75S1149VQPTCVNSTFDSPAH
Site 76T1150QPTCVNSTFDSPAHW
Site 77S1153CVNSTFDSPAHWAQK
Site 78S1162AHWAQKGSHQISLDN
Site 79S1166QKGSHQISLDNPDYQ
Site 80Y1172ISLDNPDYQQDFFPK
Site 81S1190PNGIFKGSTAENAEY
Site 82T1191NGIFKGSTAENAEYL
Site 83Y1197STAENAEYLRVAPQS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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