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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PGK1
Full Name:
Phosphoglycerate kinase 1
Alias:
Cell migration-inducing gene 10 protein; EC 2.7.2.3; PGKA; Primer recognition protein 2; PRP2
Type:
Enzyme, glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein
Mass (Da):
44615
Number AA:
417
UniProt ID:
P00558
International Prot ID:
IPI00169383
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004618
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
GO:0016310
Phosida
TranscriptoNet
STRING
Kinexus Products
Phosphoglycerate kinase 1 Y196 phosphosite-specific antibody AB-PN525#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN525#Phosphoglycerate kinase 1 (E193-K199, human) pY196 phosphopeptide - Powder PE-04ADF85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADF85#Phosphoglycerate kinase 1 (E193-K199, human) pY196 phosphopeptide - Powder PE-04AWV00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AWV00
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
L
S
N
K
L
T
L
D
K
L
D
V
K
Site 2
S57
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
Site 3
S62
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
Site 4
Y76
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
Site 5
S77
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
Site 6
S115
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
Site 7
S136
E
G
K
G
K
D
A
S
G
N
K
V
K
A
E
Site 8
S153
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Site 9
S155
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
Site 10
Y161
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
Site 11
S174
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
Site 12
Y196
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
Phosphoglycerate kinase 1 Y196 phosphosite-specific antibody AB-PN525#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN525#Phosphoglycerate kinase 1 (E193-K199, human) pY196 phosphopeptide - Powder PE-04ADF85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADF85#Phosphoglycerate kinase 1 (E193-K199, human) pY196 phosphopeptide - Powder PE-04AWV00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AWV00
Site 13
S203
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
Site 14
T243
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
Site 15
S256
N
N
M
E
I
G
T
S
L
F
D
E
E
G
A
Site 16
S271
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
Site 17
T288
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
Site 18
T298
K
F
D
E
N
A
K
T
G
Q
A
T
V
A
S
Site 19
T302
N
A
K
T
G
Q
A
T
V
A
S
G
I
P
A
Site 20
S320
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
Site 21
S321
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
Site 22
Y324
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
Site 23
T352
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
Site 24
T376
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
Site 25
T378
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
Site 26
S390
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
Site 27
S393
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
Site 28
T394
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
Site 29
S399
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
Site 30
S415
L
P
G
V
D
A
L
S
N
I
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation