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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLAT
Full Name:
Tissue-type plasminogen activator
Alias:
name.">INN=
Alteplase
Type:
Mass (Da):
62917
Number AA:
562
UniProt ID:
P00750
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
R
F
R
R
G
A
R
S
Y
Q
V
I
C
R
D
Site 2
Y37
F
R
R
G
A
R
S
Y
Q
V
I
C
R
D
E
Site 3
Y50
D
E
K
T
Q
M
I
Y
Q
Q
H
Q
S
W
L
Site 4
Y68
L
R
S
N
R
V
E
Y
C
W
C
N
S
G
R
Site 5
S80
S
G
R
A
Q
C
H
S
V
P
V
K
S
C
S
Site 6
S87
S
V
P
V
K
S
C
S
E
P
R
C
F
N
G
Site 7
Y128
I
D
T
R
A
T
C
Y
E
D
Q
G
I
S
Y
Site 8
T138
Q
G
I
S
Y
R
G
T
W
S
T
A
E
S
G
Site 9
S140
I
S
Y
R
G
T
W
S
T
A
E
S
G
A
E
Site 10
T141
S
Y
R
G
T
W
S
T
A
E
S
G
A
E
C
Site 11
T149
A
E
S
G
A
E
C
T
N
W
N
S
S
A
L
Site 12
Y161
S
A
L
A
Q
K
P
Y
S
G
R
R
P
D
A
Site 13
S162
A
L
A
Q
K
P
Y
S
G
R
R
P
D
A
I
Site 14
Y178
L
G
L
G
N
H
N
Y
C
R
N
P
D
R
D
Site 15
Y191
R
D
S
K
P
W
C
Y
V
F
K
A
G
K
Y
Site 16
Y198
Y
V
F
K
A
G
K
Y
S
S
E
F
C
S
T
Site 17
S199
V
F
K
A
G
K
Y
S
S
E
F
C
S
T
P
Site 18
S200
F
K
A
G
K
Y
S
S
E
F
C
S
T
P
A
Site 19
S204
K
Y
S
S
E
F
C
S
T
P
A
C
S
E
G
Site 20
T205
Y
S
S
E
F
C
S
T
P
A
C
S
E
G
N
Site 21
Y216
S
E
G
N
S
D
C
Y
F
G
N
G
S
A
Y
Site 22
T226
N
G
S
A
Y
R
G
T
H
S
L
T
E
S
G
Site 23
S228
S
A
Y
R
G
T
H
S
L
T
E
S
G
A
S
Site 24
T230
Y
R
G
T
H
S
L
T
E
S
G
A
S
C
L
Site 25
S232
G
T
H
S
L
T
E
S
G
A
S
C
L
P
W
Site 26
S235
S
L
T
E
S
G
A
S
C
L
P
W
N
S
M
Site 27
Y266
L
G
L
G
K
H
N
Y
C
R
N
P
D
G
D
Site 28
T287
V
L
K
N
R
R
L
T
W
E
Y
C
D
V
P
Site 29
Y290
N
R
R
L
T
W
E
Y
C
D
V
P
S
C
S
Site 30
Y304
S
T
C
G
L
R
Q
Y
S
Q
P
Q
F
R
I
Site 31
S305
T
C
G
L
R
Q
Y
S
Q
P
Q
F
R
I
K
Site 32
S335
I
F
A
K
H
R
R
S
P
G
E
R
F
L
C
Site 33
T369
R
F
P
P
H
H
L
T
V
I
L
G
R
T
Y
Site 34
Y376
T
V
I
L
G
R
T
Y
R
V
V
P
G
E
E
Site 35
Y392
Q
K
F
E
V
E
K
Y
I
V
H
K
E
F
D
Site 36
T402
H
K
E
F
D
D
D
T
Y
D
N
D
I
A
L
Site 37
Y403
K
E
F
D
D
D
T
Y
D
N
D
I
A
L
L
Site 38
S414
I
A
L
L
Q
L
K
S
D
S
S
R
C
A
Q
Site 39
S416
L
L
Q
L
K
S
D
S
S
R
C
A
Q
E
S
Site 40
S417
L
Q
L
K
S
D
S
S
R
C
A
Q
E
S
S
Site 41
S423
S
S
R
C
A
Q
E
S
S
V
V
R
T
V
C
Site 42
T428
Q
E
S
S
V
V
R
T
V
C
L
P
P
A
D
Site 43
T442
D
L
Q
L
P
D
W
T
E
C
E
L
S
G
Y
Site 44
Y449
T
E
C
E
L
S
G
Y
G
K
H
E
A
L
S
Site 45
S456
Y
G
K
H
E
A
L
S
P
F
Y
S
E
R
L
Site 46
S460
E
A
L
S
P
F
Y
S
E
R
L
K
E
A
H
Site 47
Y471
K
E
A
H
V
R
L
Y
P
S
S
R
C
T
S
Site 48
S473
A
H
V
R
L
Y
P
S
S
R
C
T
S
Q
H
Site 49
S474
H
V
R
L
Y
P
S
S
R
C
T
S
Q
H
L
Site 50
T477
L
Y
P
S
S
R
C
T
S
Q
H
L
L
N
R
Site 51
S478
Y
P
S
S
R
C
T
S
Q
H
L
L
N
R
T
Site 52
T485
S
Q
H
L
L
N
R
T
V
T
D
N
M
L
C
Site 53
T496
N
M
L
C
A
G
D
T
R
S
G
G
P
Q
A
Site 54
S498
L
C
A
G
D
T
R
S
G
G
P
Q
A
N
L
Site 55
Y546
Q
K
D
V
P
G
V
Y
T
K
V
T
N
Y
L
Site 56
Y552
V
Y
T
K
V
T
N
Y
L
D
W
I
R
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation