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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BF
Full Name:
Complement factor B
Alias:
B-factor, properdin; BFD; C3 proaccelerator; C3 proactivator; C3/C5 convertase; CFAB; CFB; EC 3.4.21.47; GBG; Glycine-rich beta glycoprotein; H2-Bf; PBF2; Properdin factor B
Type:
Protease; EC 3.4.21.47
Mass (Da):
85533
Number AA:
764
UniProt ID:
P00751
International Prot ID:
IPI00218508
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0001848
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006957
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
L
S
G
G
V
T
T
T
P
W
S
L
A
R
P
Site 2
S29
G
V
T
T
T
P
W
S
L
A
R
P
Q
G
S
Site 3
S36
S
L
A
R
P
Q
G
S
C
S
L
E
G
V
E
Site 4
S38
A
R
P
Q
G
S
C
S
L
E
G
V
E
I
K
Site 5
S48
G
V
E
I
K
G
G
S
F
R
L
L
Q
E
G
Site 6
Y60
Q
E
G
Q
A
L
E
Y
V
C
P
S
G
F
Y
Site 7
Y67
Y
V
C
P
S
G
F
Y
P
Y
P
V
Q
T
R
Site 8
Y69
C
P
S
G
F
Y
P
Y
P
V
Q
T
R
T
C
Site 9
T75
P
Y
P
V
Q
T
R
T
C
R
S
T
G
S
W
Site 10
S78
V
Q
T
R
T
C
R
S
T
G
S
W
S
T
L
Site 11
T79
Q
T
R
T
C
R
S
T
G
S
W
S
T
L
K
Site 12
S81
R
T
C
R
S
T
G
S
W
S
T
L
K
T
Q
Site 13
T87
G
S
W
S
T
L
K
T
Q
D
Q
K
T
V
R
Site 14
T92
L
K
T
Q
D
Q
K
T
V
R
K
A
E
C
R
Site 15
Y114
H
D
F
E
N
G
E
Y
W
P
R
S
P
Y
Y
Site 16
Y120
E
Y
W
P
R
S
P
Y
Y
N
V
S
D
E
I
Site 17
Y121
Y
W
P
R
S
P
Y
Y
N
V
S
D
E
I
S
Site 18
Y132
D
E
I
S
F
H
C
Y
D
G
Y
T
L
R
G
Site 19
Y135
S
F
H
C
Y
D
G
Y
T
L
R
G
S
A
N
Site 20
S140
D
G
Y
T
L
R
G
S
A
N
R
T
C
Q
V
Site 21
T144
L
R
G
S
A
N
R
T
C
Q
V
N
G
R
W
Site 22
Y164
I
C
D
N
G
A
G
Y
C
S
N
P
G
I
P
Site 23
S166
D
N
G
A
G
Y
C
S
N
P
G
I
P
I
G
Site 24
S179
I
G
T
R
K
V
G
S
Q
Y
R
L
E
D
S
Site 25
S186
S
Q
Y
R
L
E
D
S
V
T
Y
H
C
S
R
Site 26
T188
Y
R
L
E
D
S
V
T
Y
H
C
S
R
G
L
Site 27
Y189
R
L
E
D
S
V
T
Y
H
C
S
R
G
L
T
Site 28
T196
Y
H
C
S
R
G
L
T
L
R
G
S
Q
R
R
Site 29
S200
R
G
L
T
L
R
G
S
Q
R
R
T
C
Q
E
Site 30
T204
L
R
G
S
Q
R
R
T
C
Q
E
G
G
S
W
Site 31
S212
C
Q
E
G
G
S
W
S
G
T
E
P
S
C
Q
Site 32
T214
E
G
G
S
W
S
G
T
E
P
S
C
Q
D
S
Site 33
S221
T
E
P
S
C
Q
D
S
F
M
Y
D
T
P
Q
Site 34
Y224
S
C
Q
D
S
F
M
Y
D
T
P
Q
E
V
A
Site 35
T226
Q
D
S
F
M
Y
D
T
P
Q
E
V
A
E
A
Site 36
Y272
P
S
G
S
M
N
I
Y
L
V
L
D
G
S
D
Site 37
S278
I
Y
L
V
L
D
G
S
D
S
I
G
A
S
N
Site 38
S284
G
S
D
S
I
G
A
S
N
F
T
G
A
K
K
Site 39
S302
N
L
I
E
K
V
A
S
Y
G
V
K
P
R
Y
Site 40
Y309
S
Y
G
V
K
P
R
Y
G
L
V
T
Y
A
T
Site 41
T313
K
P
R
Y
G
L
V
T
Y
A
T
Y
P
K
I
Site 42
Y314
P
R
Y
G
L
V
T
Y
A
T
Y
P
K
I
W
Site 43
S325
P
K
I
W
V
K
V
S
E
A
D
S
S
N
A
Site 44
S329
V
K
V
S
E
A
D
S
S
N
A
D
W
V
T
Site 45
S330
K
V
S
E
A
D
S
S
N
A
D
W
V
T
K
Site 46
Y344
K
Q
L
N
E
I
N
Y
E
D
H
K
L
K
S
Site 47
S351
Y
E
D
H
K
L
K
S
G
T
N
T
K
K
A
Site 48
T355
K
L
K
S
G
T
N
T
K
K
A
L
Q
A
V
Site 49
Y363
K
K
A
L
Q
A
V
Y
S
M
M
S
W
P
D
Site 50
T400
N
M
G
G
D
P
I
T
V
I
D
E
I
R
D
Site 51
Y410
D
E
I
R
D
L
L
Y
I
G
K
D
R
K
N
Site 52
Y422
R
K
N
P
R
E
D
Y
L
D
V
Y
V
F
G
Site 53
Y466
E
N
L
E
D
V
F
Y
Q
M
I
D
E
S
Q
Site 54
S472
F
Y
Q
M
I
D
E
S
Q
S
L
S
L
C
G
Site 55
Y490
E
H
R
K
G
T
D
Y
H
K
Q
P
W
Q
A
Site 56
S500
Q
P
W
Q
A
K
I
S
V
I
R
P
S
K
G
Site 57
S505
K
I
S
V
I
R
P
S
K
G
H
E
S
C
M
Site 58
T529
L
T
A
A
H
C
F
T
V
D
D
K
E
H
S
Site 59
S536
T
V
D
D
K
E
H
S
I
K
V
S
V
G
G
Site 60
S540
K
E
H
S
I
K
V
S
V
G
G
E
K
R
D
Site 61
Y559
V
V
L
F
H
P
N
Y
N
I
N
G
K
K
E
Site 62
T591
N
K
L
K
Y
G
Q
T
I
R
P
I
C
L
P
Site 63
T612
R
A
L
R
L
P
P
T
T
T
C
Q
Q
Q
K
Site 64
T613
A
L
R
L
P
P
T
T
T
C
Q
Q
Q
K
E
Site 65
T641
S
E
E
E
K
K
L
T
R
K
E
V
Y
I
K
Site 66
S655
K
N
G
D
K
K
G
S
C
E
R
D
A
Q
Y
Site 67
Y662
S
C
E
R
D
A
Q
Y
A
P
G
Y
D
K
V
Site 68
Y666
D
A
Q
Y
A
P
G
Y
D
K
V
K
D
I
S
Site 69
S673
Y
D
K
V
K
D
I
S
E
V
V
T
P
R
F
Site 70
S687
F
L
C
T
G
G
V
S
P
Y
A
D
P
N
T
Site 71
Y689
C
T
G
G
V
S
P
Y
A
D
P
N
T
C
R
Site 72
T694
S
P
Y
A
D
P
N
T
C
R
G
D
S
G
G
Site 73
S699
P
N
T
C
R
G
D
S
G
G
P
L
I
V
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation