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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
REN
Full Name:
Renin
Alias:
Angiotensinogenase
Type:
Mass (Da):
45057
Number AA:
406
UniProt ID:
P00797
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
T
F
G
L
P
T
D
T
T
T
F
K
R
I
F
Site 2
T30
G
L
P
T
D
T
T
T
F
K
R
I
F
L
K
Site 3
S41
I
F
L
K
R
M
P
S
I
R
E
S
L
K
E
Site 4
S45
R
M
P
S
I
R
E
S
L
K
E
R
G
V
D
Site 5
S61
A
R
L
G
P
E
W
S
Q
P
M
K
R
L
T
Site 6
T68
S
Q
P
M
K
R
L
T
L
G
N
T
T
S
S
Site 7
T79
T
T
S
S
V
I
L
T
N
Y
M
D
T
Q
Y
Site 8
Y81
S
S
V
I
L
T
N
Y
M
D
T
Q
Y
Y
G
Site 9
Y86
T
N
Y
M
D
T
Q
Y
Y
G
E
I
G
I
G
Site 10
Y87
N
Y
M
D
T
Q
Y
Y
G
E
I
G
I
G
T
Site 11
T94
Y
G
E
I
G
I
G
T
P
P
Q
T
F
K
V
Site 12
S107
K
V
V
F
D
T
G
S
S
N
V
W
V
P
S
Site 13
S114
S
S
N
V
W
V
P
S
S
K
C
S
R
L
Y
Site 14
S115
S
N
V
W
V
P
S
S
K
C
S
R
L
Y
T
Site 15
Y121
S
S
K
C
S
R
L
Y
T
A
C
V
Y
H
K
Site 16
T122
S
K
C
S
R
L
Y
T
A
C
V
Y
H
K
L
Site 17
S133
Y
H
K
L
F
D
A
S
D
S
S
S
Y
K
H
Site 18
S135
K
L
F
D
A
S
D
S
S
S
Y
K
H
N
G
Site 19
S136
L
F
D
A
S
D
S
S
S
Y
K
H
N
G
T
Site 20
S137
F
D
A
S
D
S
S
S
Y
K
H
N
G
T
E
Site 21
T146
K
H
N
G
T
E
L
T
L
R
Y
S
T
G
T
Site 22
S150
T
E
L
T
L
R
Y
S
T
G
T
V
S
G
F
Site 23
T153
T
L
R
Y
S
T
G
T
V
S
G
F
L
S
Q
Site 24
S155
R
Y
S
T
G
T
V
S
G
F
L
S
Q
D
I
Site 25
S215
P
I
F
D
N
I
I
S
Q
G
V
L
K
E
D
Site 26
S225
V
L
K
E
D
V
F
S
F
Y
Y
N
R
D
S
Site 27
Y227
K
E
D
V
F
S
F
Y
Y
N
R
D
S
E
N
Site 28
Y228
E
D
V
F
S
F
Y
Y
N
R
D
S
E
N
S
Site 29
S232
S
F
Y
Y
N
R
D
S
E
N
S
Q
S
L
G
Site 30
S235
Y
N
R
D
S
E
N
S
Q
S
L
G
G
Q
I
Site 31
S237
R
D
S
E
N
S
Q
S
L
G
G
Q
I
V
L
Site 32
S247
G
Q
I
V
L
G
G
S
D
P
Q
H
Y
E
G
Site 33
Y252
G
G
S
D
P
Q
H
Y
E
G
N
F
H
Y
I
Site 34
Y258
H
Y
E
G
N
F
H
Y
I
N
L
I
K
T
G
Site 35
Y297
L
V
D
T
G
A
S
Y
I
S
G
S
T
S
S
Site 36
S299
D
T
G
A
S
Y
I
S
G
S
T
S
S
I
E
Site 37
S301
G
A
S
Y
I
S
G
S
T
S
S
I
E
K
L
Site 38
S303
S
Y
I
S
G
S
T
S
S
I
E
K
L
M
E
Site 39
S304
Y
I
S
G
S
T
S
S
I
E
K
L
M
E
A
Site 40
Y321
A
K
K
R
L
F
D
Y
V
V
K
C
N
E
G
Site 41
T330
V
K
C
N
E
G
P
T
L
P
D
I
S
F
H
Site 42
S335
G
P
T
L
P
D
I
S
F
H
L
G
G
K
E
Site 43
T346
G
G
K
E
Y
T
L
T
S
A
D
Y
V
F
Q
Site 44
S347
G
K
E
Y
T
L
T
S
A
D
Y
V
F
Q
E
Site 45
Y350
Y
T
L
T
S
A
D
Y
V
F
Q
E
S
Y
S
Site 46
S355
A
D
Y
V
F
Q
E
S
Y
S
S
K
K
L
C
Site 47
Y356
D
Y
V
F
Q
E
S
Y
S
S
K
K
L
C
T
Site 48
Y390
A
T
F
I
R
K
F
Y
T
E
F
D
R
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation