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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADA
Full Name:
Adenosine deaminase
Alias:
Adenosine aminohydrolase; EC 3.5.4.4
Type:
Nucleotide Metabolism - purine; EC 3.5.4.4; Hydrolase
Mass (Da):
40764
Number AA:
363
UniProt ID:
P00813
International Prot ID:
IPI00296441
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0009897
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004000
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0042110
GO:0006154
GO:0046103
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
A
Q
T
P
A
F
D
K
P
K
Site 2
T26
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
Site 3
Y29
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
Site 4
Y30
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
Site 5
Y67
D
F
L
A
K
F
D
Y
Y
M
P
A
I
A
G
Site 6
Y84
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
Site 7
Y97
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
Site 8
S103
V
Y
V
E
V
R
Y
S
P
H
L
L
A
N
S
Site 9
T125
N
Q
A
E
G
D
L
T
P
D
E
V
V
A
L
Site 10
S191
G
D
E
T
I
P
G
S
S
L
L
P
G
H
V
Site 11
S192
D
E
T
I
P
G
S
S
L
L
P
G
H
V
Q
Site 12
S207
A
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
Site 13
T212
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
Site 14
T233
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
Site 15
Y240
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
Site 16
T242
R
L
G
H
G
Y
H
T
L
E
D
Q
A
L
Y
Site 17
Y249
T
L
E
D
Q
A
L
Y
N
R
L
R
Q
E
N
Site 18
Y267
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
Site 19
T276
T
G
A
W
K
P
D
T
E
H
A
V
I
R
L
Site 20
Y290
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
Site 21
S291
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
Site 22
S302
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
Site 23
T306
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
Site 24
Y308
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
Site 25
T318
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
Site 26
S333
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
Site 27
Y348
R
E
L
L
D
L
L
Y
K
A
Y
G
M
P
P
Site 28
Y351
L
D
L
L
Y
K
A
Y
G
M
P
P
S
A
S
Site 29
S356
K
A
Y
G
M
P
P
S
A
S
A
G
Q
N
L
Site 30
S358
Y
G
M
P
P
S
A
S
A
G
Q
N
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation