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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASS1
Full Name:
Argininosuccinate synthase
Alias:
Argininosuccinate synthetase; ASS; ASSY; Citrulline-aspartate ligase; Citrulline--aspartate ligase; CTLN1; EC 6.3.4.5
Type:
Enzyme - Synthetase
Mass (Da):
46530
Number AA:
412
UniProt ID:
P00966
International Prot ID:
IPI00020632
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004055
PhosphoSite+
KinaseNET
Biological Process:
GO:0000050
GO:0006082
GO:0006519
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y34
Q
G
Y
D
V
I
A
Y
L
A
N
I
G
Q
K
Site 2
S65
K
V
F
I
E
D
V
S
R
E
F
V
E
E
F
Site 3
Y83
A
I
Q
S
S
A
L
Y
E
D
R
Y
L
L
G
Site 4
Y87
S
A
L
Y
E
D
R
Y
L
L
G
T
S
L
A
Site 5
T91
E
D
R
Y
L
L
G
T
S
L
A
R
P
C
I
Site 6
S92
D
R
Y
L
L
G
T
S
L
A
R
P
C
I
A
Site 7
Y113
A
Q
R
E
G
A
K
Y
V
S
H
G
A
T
G
Site 8
S115
R
E
G
A
K
Y
V
S
H
G
A
T
G
K
G
Site 9
S131
D
Q
V
R
F
E
L
S
C
Y
S
L
A
P
Q
Site 10
Y133
V
R
F
E
L
S
C
Y
S
L
A
P
Q
I
K
Site 11
S134
R
F
E
L
S
C
Y
S
L
A
P
Q
I
K
V
Site 12
Y151
P
W
R
M
P
E
F
Y
N
R
F
K
G
R
N
Site 13
Y163
G
R
N
D
L
M
E
Y
A
K
Q
H
G
I
P
Site 14
T174
H
G
I
P
I
P
V
T
P
K
N
P
W
S
M
Site 15
S180
V
T
P
K
N
P
W
S
M
D
E
N
L
M
H
Site 16
Y190
E
N
L
M
H
I
S
Y
E
A
G
I
L
E
N
Site 17
Y207
N
Q
A
P
P
G
L
Y
T
K
T
Q
D
P
A
Site 18
T210
P
P
G
L
Y
T
K
T
Q
D
P
A
K
A
P
Site 19
T219
D
P
A
K
A
P
N
T
P
D
I
L
E
I
E
Site 20
T243
T
N
V
K
D
G
T
T
H
Q
T
S
L
E
L
Site 21
S247
D
G
T
T
H
Q
T
S
L
E
L
F
M
Y
L
Site 22
Y282
G
M
K
S
R
G
I
Y
E
T
P
A
G
T
I
Site 23
T284
K
S
R
G
I
Y
E
T
P
A
G
T
I
L
Y
Site 24
T288
I
Y
E
T
P
A
G
T
I
L
Y
H
A
H
L
Site 25
Y322
L
K
F
A
E
L
V
Y
T
G
F
W
H
S
P
Site 26
T323
K
F
A
E
L
V
Y
T
G
F
W
H
S
P
E
Site 27
S341
V
R
H
C
I
A
K
S
Q
E
R
V
E
G
K
Site 28
S352
V
E
G
K
V
Q
V
S
V
L
K
G
Q
V
Y
Site 29
Y359
S
V
L
K
G
Q
V
Y
I
L
G
R
E
S
P
Site 30
S365
V
Y
I
L
G
R
E
S
P
L
S
L
Y
N
E
Site 31
S368
L
G
R
E
S
P
L
S
L
Y
N
E
E
L
V
Site 32
Y370
R
E
S
P
L
S
L
Y
N
E
E
L
V
S
M
Site 33
Y383
S
M
N
V
Q
G
D
Y
E
P
T
D
A
T
G
Site 34
S396
T
G
F
I
N
I
N
S
L
R
L
K
E
Y
H
Site 35
Y402
N
S
L
R
L
K
E
Y
H
R
L
Q
S
K
V
Site 36
S407
K
E
Y
H
R
L
Q
S
K
V
T
A
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation