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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OAS1
Full Name:
2'-5'-oligoadenylate synthase 1
Alias:
(2'-5') oligoadenylate synthetase 1; 2',5'-oligo A synthetase 1; E18/E16; IFI-4; NET2; OIAS; OIASI; p46/p42 OAS
Type:
EC 2.7.7.-; Transferase
Mass (Da):
46059
Number AA:
400
UniProt ID:
P00973
International Prot ID:
IPI00305585
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005792
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003723
GO:0016779
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
M
D
L
R
N
T
P
A
K
S
L
D
K
Site 2
S11
L
R
N
T
P
A
K
S
L
D
K
F
I
E
D
Site 3
S49
K
E
R
C
F
R
G
S
S
Y
P
V
C
V
S
Site 4
S50
E
R
C
F
R
G
S
S
Y
P
V
C
V
S
K
Site 5
Y51
R
C
F
R
G
S
S
Y
P
V
C
V
S
K
V
Site 6
S63
S
K
V
V
K
G
G
S
S
G
K
G
T
T
L
Site 7
T68
G
G
S
S
G
K
G
T
T
L
R
G
R
S
D
Site 8
T69
G
S
S
G
K
G
T
T
L
R
G
R
S
D
A
Site 9
T87
V
F
L
S
P
L
T
T
F
Q
D
Q
L
N
R
Site 10
S116
C
Q
R
E
R
A
F
S
V
K
F
E
V
Q
A
Site 11
T160
F
D
A
L
G
Q
L
T
G
S
Y
K
P
N
P
Site 12
S162
A
L
G
Q
L
T
G
S
Y
K
P
N
P
Q
I
Site 13
Y163
L
G
Q
L
T
G
S
Y
K
P
N
P
Q
I
Y
Site 14
Y170
Y
K
P
N
P
Q
I
Y
V
K
L
I
E
E
C
Site 15
S187
L
Q
K
E
G
E
F
S
T
C
F
T
E
L
Q
Site 16
T191
G
E
F
S
T
C
F
T
E
L
Q
R
D
F
L
Site 17
T203
D
F
L
K
Q
R
P
T
K
L
K
S
L
I
R
Site 18
S207
Q
R
P
T
K
L
K
S
L
I
R
L
V
K
H
Site 19
Y216
I
R
L
V
K
H
W
Y
Q
N
C
K
K
K
L
Site 20
T236
Q
Y
A
L
E
L
L
T
V
Y
A
W
E
R
G
Site 21
Y271
N
Y
Q
Q
L
C
I
Y
W
T
K
Y
Y
D
F
Site 22
Y286
K
N
P
I
I
E
K
Y
L
R
R
Q
L
T
K
Site 23
T292
K
Y
L
R
R
Q
L
T
K
P
R
P
V
I
L
Site 24
T305
I
L
D
P
A
D
P
T
G
N
L
G
G
G
D
Site 25
S341
N
W
D
G
S
P
V
S
S
W
I
L
L
A
E
Site 26
S351
I
L
L
A
E
S
N
S
A
D
D
E
T
D
D
Site 27
T356
S
N
S
A
D
D
E
T
D
D
P
R
R
Y
Q
Site 28
Y362
E
T
D
D
P
R
R
Y
Q
K
Y
G
Y
I
G
Site 29
Y365
D
P
R
R
Y
Q
K
Y
G
Y
I
G
T
H
E
Site 30
Y373
G
Y
I
G
T
H
E
Y
P
H
F
S
H
R
P
Site 31
S377
T
H
E
Y
P
H
F
S
H
R
P
S
T
L
Q
Site 32
S381
P
H
F
S
H
R
P
S
T
L
Q
A
A
S
T
Site 33
T382
H
F
S
H
R
P
S
T
L
Q
A
A
S
T
P
Site 34
T388
S
T
L
Q
A
A
S
T
P
Q
A
E
E
D
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation