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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SERPINC1
Full Name:
Antithrombin-III
Alias:
ANT3; Antithrombin; Antithrombin (aa 375-432); Antithrombin (Antithrombin III); Antithrombin III; Antithrombin-III; AT3; ATIII; Coding sequence signal peptide antithrombin part 1; MGC22579; Serine or cysteine proteinase inhibitor, clade C member 1; Serpin peptidase inhibitor, clade C (antithrombin) member 1; Serpin peptidase inhibitor, clade C, member 1; Signal peptide antithrombin part 1
Type:
Inhibitor protein
Mass (Da):
52602
Number AA:
464
UniProt ID:
P01008
International Prot ID:
IPI00032179
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008201
GO:0002020
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
S
N
V
I
G
T
V
T
S
G
K
R
K
V
Y
Site 2
S11
N
V
I
G
T
V
T
S
G
K
R
K
V
Y
L
Site 3
T41
G
S
P
V
D
I
C
T
A
K
P
R
D
I
P
Site 4
Y55
P
M
N
P
M
C
I
Y
R
S
P
E
K
K
A
Site 5
S57
N
P
M
C
I
Y
R
S
P
E
K
K
A
T
E
Site 6
T63
R
S
P
E
K
K
A
T
E
D
E
G
S
E
Q
Site 7
S68
K
A
T
E
D
E
G
S
E
Q
K
I
P
E
A
Site 8
T76
E
Q
K
I
P
E
A
T
N
R
R
V
W
E
L
Site 9
S84
N
R
R
V
W
E
L
S
K
A
N
S
R
F
A
Site 10
S88
W
E
L
S
K
A
N
S
R
F
A
T
T
F
Y
Site 11
T92
K
A
N
S
R
F
A
T
T
F
Y
Q
H
L
A
Site 12
T93
A
N
S
R
F
A
T
T
F
Y
Q
H
L
A
D
Site 13
Y95
S
R
F
A
T
T
F
Y
Q
H
L
A
D
S
K
Site 14
S111
D
N
D
N
I
F
L
S
P
L
S
I
S
T
A
Site 15
T130
K
L
G
A
C
N
D
T
L
Q
Q
L
M
E
V
Site 16
T142
M
E
V
F
K
F
D
T
I
S
E
K
T
S
D
Site 17
S144
V
F
K
F
D
T
I
S
E
K
T
S
D
Q
I
Site 18
Y163
A
K
L
N
C
R
L
Y
R
K
A
N
K
S
S
Site 19
S169
L
Y
R
K
A
N
K
S
S
K
L
V
S
A
N
Site 20
S170
Y
R
K
A
N
K
S
S
K
L
V
S
A
N
R
Site 21
S174
N
K
S
S
K
L
V
S
A
N
R
L
F
G
D
Site 22
S183
N
R
L
F
G
D
K
S
L
T
F
N
E
T
Y
Site 23
T185
L
F
G
D
K
S
L
T
F
N
E
T
Y
Q
D
Site 24
T189
K
S
L
T
F
N
E
T
Y
Q
D
I
S
E
L
Site 25
Y190
S
L
T
F
N
E
T
Y
Q
D
I
S
E
L
V
Site 26
S194
N
E
T
Y
Q
D
I
S
E
L
V
Y
G
A
K
Site 27
Y198
Q
D
I
S
E
L
V
Y
G
A
K
L
Q
P
L
Site 28
S214
F
K
E
N
A
E
Q
S
R
A
A
I
N
K
W
Site 29
T231
N
K
T
E
G
R
I
T
D
V
I
P
S
E
A
Site 30
S262
G
L
W
K
S
K
F
S
P
E
N
T
R
K
E
Site 31
T266
S
K
F
S
P
E
N
T
R
K
E
L
F
Y
K
Site 32
Y272
N
T
R
K
E
L
F
Y
K
A
D
G
E
S
C
Site 33
S280
K
A
D
G
E
S
C
S
A
S
M
M
Y
Q
E
Site 34
S282
D
G
E
S
C
S
A
S
M
M
Y
Q
E
G
K
Site 35
Y285
S
C
S
A
S
M
M
Y
Q
E
G
K
F
R
Y
Site 36
Y292
Y
Q
E
G
K
F
R
Y
R
R
V
A
E
G
T
Site 37
T299
Y
R
R
V
A
E
G
T
Q
V
L
E
L
P
F
Site 38
S323
I
L
P
K
P
E
K
S
L
A
K
V
E
K
E
Site 39
T332
A
K
V
E
K
E
L
T
P
E
V
L
Q
E
W
Site 40
S362
F
R
I
E
D
G
F
S
L
K
E
Q
L
Q
D
Site 41
S377
M
G
L
V
D
L
F
S
P
E
K
S
K
L
P
Site 42
S381
D
L
F
S
P
E
K
S
K
L
P
G
I
V
A
Site 43
Y395
A
E
G
R
D
D
L
Y
V
S
D
A
F
H
K
Site 44
S397
G
R
D
D
L
Y
V
S
D
A
F
H
K
A
F
Site 45
T433
S
L
N
P
N
R
V
T
F
K
A
N
R
P
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation