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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SERPINA3
Full Name:
Alpha-1-antichymotrypsin
Alias:
AACT; ACT; Alpha-1-antichymotrypsin; Cell growth-inhibiting gene 24/25 protein; Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin) member 3; SPA3N
Type:
Mass (Da):
47632
Number AA:
423
UniProt ID:
P01011
International Prot ID:
IPI00431656
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0006953
GO:0030277
GO:0019216
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
A
V
L
C
H
P
N
S
P
L
D
E
E
N
L
Site 2
T35
P
L
D
E
E
N
L
T
Q
E
N
Q
D
R
G
Site 3
T43
Q
E
N
Q
D
R
G
T
H
V
D
L
G
L
A
Site 4
T97
G
A
H
N
T
T
L
T
E
I
L
K
G
L
K
Site 5
T108
K
G
L
K
F
N
L
T
E
T
S
E
A
E
I
Site 6
S118
S
E
A
E
I
H
Q
S
F
Q
H
L
L
R
T
Site 7
T125
S
F
Q
H
L
L
R
T
L
N
Q
S
S
D
E
Site 8
S129
L
L
R
T
L
N
Q
S
S
D
E
L
Q
L
S
Site 9
S130
L
R
T
L
N
Q
S
S
D
E
L
Q
L
S
M
Site 10
S148
M
F
V
K
E
Q
L
S
L
L
D
R
F
T
E
Site 11
T154
L
S
L
L
D
R
F
T
E
D
A
K
R
L
Y
Site 12
Y161
T
E
D
A
K
R
L
Y
G
S
E
A
F
A
T
Site 13
T168
Y
G
S
E
A
F
A
T
D
F
Q
D
S
A
A
Site 14
Y183
A
K
K
L
I
N
D
Y
V
K
N
G
T
R
G
Site 15
T226
M
P
F
D
P
Q
D
T
H
Q
S
R
F
Y
L
Site 16
Y232
D
T
H
Q
S
R
F
Y
L
S
K
K
K
W
V
Site 17
Y253
L
H
H
L
T
I
P
Y
F
R
D
E
E
L
S
Site 18
S260
Y
F
R
D
E
E
L
S
C
T
V
V
E
L
K
Site 19
T262
R
D
E
E
L
S
C
T
V
V
E
L
K
Y
T
Site 20
T295
E
A
M
L
L
P
E
T
L
K
R
W
R
D
S
Site 21
S302
T
L
K
R
W
R
D
S
L
E
F
R
E
I
G
Site 22
Y312
F
R
E
I
G
E
L
Y
L
P
K
F
S
I
S
Site 23
S317
E
L
Y
L
P
K
F
S
I
S
R
D
Y
N
L
Site 24
Y322
K
F
S
I
S
R
D
Y
N
L
N
D
I
L
L
Site 25
T338
L
G
I
E
E
A
F
T
S
K
A
D
L
S
G
Site 26
S339
G
I
E
E
A
F
T
S
K
A
D
L
S
G
I
Site 27
S344
F
T
S
K
A
D
L
S
G
I
T
G
A
R
N
Site 28
T391
S
A
L
V
E
T
R
T
I
V
R
F
N
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation