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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
A2M
Full Name:
Alpha-2-macroglobulin
Alias:
A2MG; A2MP; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; FWP007; S863-7
Type:
Inhibitor protein
Mass (Da):
163292
Number AA:
1474
UniProt ID:
P01023
International Prot ID:
IPI00478003
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0031093
GO:0031974
Uniprot
OncoNet
Molecular Function:
GO:0004857
GO:0004866
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0006461
GO:0007584
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
V
L
L
P
T
D
A
S
V
S
G
K
P
Q
Y
Site 2
S26
L
P
T
D
A
S
V
S
G
K
P
Q
Y
M
V
Site 3
T41
L
V
P
S
L
L
H
T
E
T
T
E
K
G
C
Site 4
T59
S
Y
L
N
E
T
V
T
V
S
A
S
L
E
S
Site 5
S61
L
N
E
T
V
T
V
S
A
S
L
E
S
V
R
Site 6
S63
E
T
V
T
V
S
A
S
L
E
S
V
R
G
N
Site 7
S66
T
V
S
A
S
L
E
S
V
R
G
N
R
S
L
Site 8
S72
E
S
V
R
G
N
R
S
L
F
T
D
L
E
A
Site 9
S94
V
A
F
A
V
P
K
S
S
S
N
E
E
V
M
Site 10
T104
N
E
E
V
M
F
L
T
V
Q
V
K
G
P
T
Site 11
T119
Q
E
F
K
K
R
T
T
V
M
V
K
N
E
D
Site 12
S136
V
F
V
Q
T
D
K
S
I
Y
K
P
G
Q
T
Site 13
S150
T
V
K
F
R
V
V
S
M
D
E
N
F
H
P
Site 14
S180
N
R
I
A
Q
W
Q
S
F
Q
L
E
G
G
L
Site 15
S191
E
G
G
L
K
Q
F
S
F
P
L
S
S
E
P
Site 16
S195
K
Q
F
S
F
P
L
S
S
E
P
F
Q
G
S
Site 17
S196
Q
F
S
F
P
L
S
S
E
P
F
Q
G
S
Y
Site 18
S202
S
S
E
P
F
Q
G
S
Y
K
V
V
V
Q
K
Site 19
Y203
S
E
P
F
Q
G
S
Y
K
V
V
V
Q
K
K
Site 20
S211
K
V
V
V
Q
K
K
S
G
G
R
T
E
H
P
Site 21
T215
Q
K
K
S
G
G
R
T
E
H
P
F
T
V
E
Site 22
T220
G
R
T
E
H
P
F
T
V
E
E
F
V
L
P
Site 23
Y256
S
V
C
G
L
Y
T
Y
G
K
P
V
P
G
H
Site 24
T265
K
P
V
P
G
H
V
T
V
S
I
C
R
K
Y
Site 25
S267
V
P
G
H
V
T
V
S
I
C
R
K
Y
S
D
Site 26
Y272
T
V
S
I
C
R
K
Y
S
D
A
S
D
C
H
Site 27
S273
V
S
I
C
R
K
Y
S
D
A
S
D
C
H
G
Site 28
S276
C
R
K
Y
S
D
A
S
D
C
H
G
E
D
S
Site 29
Y301
L
N
S
H
G
C
F
Y
Q
Q
V
K
T
K
V
Site 30
Y316
F
Q
L
K
R
K
E
Y
E
M
K
L
H
T
E
Site 31
T331
A
Q
I
Q
E
E
G
T
V
V
E
L
T
G
R
Site 32
T336
E
G
T
V
V
E
L
T
G
R
Q
S
S
E
I
Site 33
S340
V
E
L
T
G
R
Q
S
S
E
I
T
R
T
I
Site 34
S341
E
L
T
G
R
Q
S
S
E
I
T
R
T
I
T
Site 35
T346
Q
S
S
E
I
T
R
T
I
T
K
L
S
F
V
Site 36
S351
T
R
T
I
T
K
L
S
F
V
K
V
D
S
H
Site 37
S357
L
S
F
V
K
V
D
S
H
F
R
Q
G
I
P
Site 38
Y393
I
R
G
N
E
A
N
Y
Y
S
N
A
T
T
D
Site 39
Y394
R
G
N
E
A
N
Y
Y
S
N
A
T
T
D
E
Site 40
T399
N
Y
Y
S
N
A
T
T
D
E
H
G
L
V
Q
Site 41
T420
N
V
M
G
T
S
L
T
V
R
V
N
Y
K
D
Site 42
Y425
S
L
T
V
R
V
N
Y
K
D
R
S
P
C
Y
Site 43
Y432
Y
K
D
R
S
P
C
Y
G
Y
Q
W
V
S
E
Site 44
Y434
D
R
S
P
C
Y
G
Y
Q
W
V
S
E
E
H
Site 45
T447
E
H
E
E
A
H
H
T
A
Y
L
V
F
S
P
Site 46
Y449
E
E
A
H
H
T
A
Y
L
V
F
S
P
S
K
Site 47
T473
H
E
L
P
C
G
H
T
Q
T
V
Q
A
H
Y
Site 48
Y480
T
Q
T
V
Q
A
H
Y
I
L
N
G
G
T
L
Site 49
Y497
L
K
K
L
S
F
Y
Y
L
I
M
A
K
G
G
Site 50
S525
E
D
M
K
G
H
F
S
I
S
I
P
V
K
S
Site 51
S555
T
G
D
V
I
G
D
S
A
K
Y
D
V
E
N
Site 52
S571
L
A
N
K
V
D
L
S
F
S
P
S
Q
S
L
Site 53
S573
N
K
V
D
L
S
F
S
P
S
Q
S
L
P
A
Site 54
S575
V
D
L
S
F
S
P
S
Q
S
L
P
A
S
H
Site 55
S577
L
S
F
S
P
S
Q
S
L
P
A
S
H
A
H
Site 56
S581
P
S
Q
S
L
P
A
S
H
A
H
L
R
V
T
Site 57
T588
S
H
A
H
L
R
V
T
A
A
P
Q
S
V
C
Site 58
S614
M
K
P
D
A
E
L
S
A
S
S
V
Y
N
L
Site 59
S616
P
D
A
E
L
S
A
S
S
V
Y
N
L
L
P
Site 60
T628
L
L
P
E
K
D
L
T
G
F
P
G
P
L
N
Site 61
Y649
C
I
N
R
H
N
V
Y
I
N
G
I
T
Y
T
Site 62
T654
N
V
Y
I
N
G
I
T
Y
T
P
V
S
S
T
Site 63
Y655
V
Y
I
N
G
I
T
Y
T
P
V
S
S
T
N
Site 64
T656
Y
I
N
G
I
T
Y
T
P
V
S
S
T
N
E
Site 65
Y667
S
T
N
E
K
D
M
Y
S
F
L
E
D
M
G
Site 66
S668
T
N
E
K
D
M
Y
S
F
L
E
D
M
G
L
Site 67
T679
D
M
G
L
K
A
F
T
N
S
K
I
R
K
P
Site 68
S681
G
L
K
A
F
T
N
S
K
I
R
K
P
K
M
Site 69
Y695
M
C
P
Q
L
Q
Q
Y
E
M
H
G
P
E
G
Site 70
Y708
E
G
L
R
V
G
F
Y
E
S
D
V
M
G
R
Site 71
S710
L
R
V
G
F
Y
E
S
D
V
M
G
R
G
H
Site 72
T728
V
H
V
E
E
P
H
T
E
T
V
R
K
Y
F
Site 73
T730
V
E
E
P
H
T
E
T
V
R
K
Y
F
P
E
Site 74
S781
E
D
A
G
L
G
I
S
S
T
A
S
L
R
A
Site 75
Y817
L
K
A
T
V
L
N
Y
L
P
K
C
I
R
V
Site 76
S857
A
N
G
R
Q
T
V
S
W
A
V
T
P
K
S
Site 77
T861
Q
T
V
S
W
A
V
T
P
K
S
L
G
N
V
Site 78
S864
S
W
A
V
T
P
K
S
L
G
N
V
N
F
T
Site 79
S879
V
S
A
E
A
L
E
S
Q
E
L
C
G
T
E
Site 80
T885
E
S
Q
E
L
C
G
T
E
V
P
S
V
P
E
Site 81
S889
L
C
G
T
E
V
P
S
V
P
E
H
G
R
K
Site 82
T898
P
E
H
G
R
K
D
T
V
I
K
P
L
L
V
Site 83
T915
E
G
L
E
K
E
T
T
F
N
S
L
L
C
P
Site 84
S918
E
K
E
T
T
F
N
S
L
L
C
P
S
G
G
Site 85
S928
C
P
S
G
G
E
V
S
E
E
L
S
L
K
L
Site 86
S932
G
E
V
S
E
E
L
S
L
K
L
P
P
N
V
Site 87
S943
P
P
N
V
V
E
E
S
A
R
A
S
V
S
V
Site 88
Y970
Q
N
L
L
Q
M
P
Y
G
C
G
E
Q
N
M
Site 89
Y989
P
N
I
Y
V
L
D
Y
L
N
E
T
Q
Q
L
Site 90
T997
L
N
E
T
Q
Q
L
T
P
E
V
K
S
K
A
Site 91
Y1007
V
K
S
K
A
I
G
Y
L
N
T
G
Y
Q
R
Site 92
Y1012
I
G
Y
L
N
T
G
Y
Q
R
Q
L
N
Y
K
Site 93
Y1018
G
Y
Q
R
Q
L
N
Y
K
H
Y
D
G
S
Y
Site 94
Y1021
R
Q
L
N
Y
K
H
Y
D
G
S
Y
S
T
F
Site 95
S1024
N
Y
K
H
Y
D
G
S
Y
S
T
F
G
E
R
Site 96
Y1025
Y
K
H
Y
D
G
S
Y
S
T
F
G
E
R
Y
Site 97
S1026
K
H
Y
D
G
S
Y
S
T
F
G
E
R
Y
G
Site 98
T1027
H
Y
D
G
S
Y
S
T
F
G
E
R
Y
G
R
Site 99
Y1032
Y
S
T
F
G
E
R
Y
G
R
N
Q
G
N
T
Site 100
S1071
T
Q
A
L
I
W
L
S
Q
R
Q
K
D
N
G
Site 101
S1082
K
D
N
G
C
F
R
S
S
G
S
L
L
N
N
Site 102
S1083
D
N
G
C
F
R
S
S
G
S
L
L
N
N
A
Site 103
S1085
G
C
F
R
S
S
G
S
L
L
N
N
A
I
K
Site 104
T1134
C
L
E
S
A
W
K
T
A
Q
E
G
D
H
G
Site 105
S1142
A
Q
E
G
D
H
G
S
H
V
Y
T
K
A
L
Site 106
T1146
D
H
G
S
H
V
Y
T
K
A
L
L
A
Y
A
Site 107
S1169
K
R
K
E
V
L
K
S
L
N
E
E
A
V
K
Site 108
S1180
E
A
V
K
K
D
N
S
V
H
W
E
R
P
Q
Site 109
Y1197
K
A
P
V
G
H
F
Y
E
P
Q
A
P
S
A
Site 110
S1225
T
A
Q
P
A
P
T
S
E
D
L
T
S
A
T
Site 111
T1229
A
P
T
S
E
D
L
T
S
A
T
N
I
V
K
Site 112
S1230
P
T
S
E
D
L
T
S
A
T
N
I
V
K
W
Site 113
T1268
L
S
K
Y
G
A
A
T
F
T
R
T
G
K
A
Site 114
T1279
T
G
K
A
A
Q
V
T
I
Q
S
S
G
T
F
Site 115
S1282
A
A
Q
V
T
I
Q
S
S
G
T
F
S
S
K
Site 116
S1283
A
Q
V
T
I
Q
S
S
G
T
F
S
S
K
F
Site 117
T1285
V
T
I
Q
S
S
G
T
F
S
S
K
F
Q
V
Site 118
S1287
I
Q
S
S
G
T
F
S
S
K
F
Q
V
D
N
Site 119
S1288
Q
S
S
G
T
F
S
S
K
F
Q
V
D
N
N
Site 120
S1304
R
L
L
L
Q
Q
V
S
L
P
E
L
P
G
E
Site 121
S1313
P
E
L
P
G
E
Y
S
M
K
V
T
G
E
G
Site 122
T1317
G
E
Y
S
M
K
V
T
G
E
G
C
V
Y
L
Site 123
S1360
D
E
P
K
A
H
T
S
F
Q
I
S
L
S
V
Site 124
S1366
T
S
F
Q
I
S
L
S
V
S
Y
T
G
S
R
Site 125
S1368
F
Q
I
S
L
S
V
S
Y
T
G
S
R
S
A
Site 126
T1370
I
S
L
S
V
S
Y
T
G
S
R
S
A
S
N
Site 127
S1372
L
S
V
S
Y
T
G
S
R
S
A
S
N
M
A
Site 128
S1376
Y
T
G
S
R
S
A
S
N
M
A
I
V
D
V
Site 129
S1387
I
V
D
V
K
M
V
S
G
F
I
P
L
K
P
Site 130
T1395
G
F
I
P
L
K
P
T
V
K
M
L
E
R
S
Site 131
S1406
L
E
R
S
N
H
V
S
R
T
E
V
S
S
N
Site 132
T1408
R
S
N
H
V
S
R
T
E
V
S
S
N
H
V
Site 133
Y1418
S
S
N
H
V
L
I
Y
L
D
K
V
S
N
Q
Site 134
Y1452
A
I
V
K
V
Y
D
Y
Y
E
T
D
E
F
A
Site 135
Y1453
I
V
K
V
Y
D
Y
Y
E
T
D
E
F
A
I
Site 136
Y1463
D
E
F
A
I
A
E
Y
N
A
P
C
S
K
D
Site 137
S1468
A
E
Y
N
A
P
C
S
K
D
L
G
N
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation