KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
C3
Full Name:
Complement C3
Alias:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; CO3; Complement C3 [Contains: C3a anaphylatoxin]; Complement component 3; CPAMD1
Type:
Inhibitor protein
Mass (Da):
187148
Number AA:
1663
UniProt ID:
P01024
International Prot ID:
IPI00783987
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004857
GO:0004866
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0001796
GO:0001798
GO:0002252
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
P
N
I
L
R
L
E
S
E
E
T
M
V
L
E
Site 2
T41
L
R
L
E
S
E
E
T
M
V
L
E
A
H
D
Site 3
T58
G
D
V
P
V
T
V
T
V
H
D
F
P
G
K
Site 4
S70
P
G
K
K
L
V
L
S
S
E
K
T
V
L
T
Site 5
S71
G
K
K
L
V
L
S
S
E
K
T
V
L
T
P
Site 6
T77
S
S
E
K
T
V
L
T
P
A
T
N
H
M
G
Site 7
T87
T
N
H
M
G
N
V
T
F
T
I
P
A
N
R
Site 8
S98
P
A
N
R
E
F
K
S
E
K
G
R
N
K
F
Site 9
T107
K
G
R
N
K
F
V
T
V
Q
A
T
F
G
T
Site 10
T137
L
F
I
Q
T
D
K
T
I
Y
T
P
G
S
T
Site 11
Y139
I
Q
T
D
K
T
I
Y
T
P
G
S
T
V
L
Site 12
T140
Q
T
D
K
T
I
Y
T
P
G
S
T
V
L
Y
Site 13
S179
G
I
P
V
K
Q
D
S
L
S
S
Q
N
Q
L
Site 14
S181
P
V
K
Q
D
S
L
S
S
Q
N
Q
L
G
V
Site 15
S182
V
K
Q
D
S
L
S
S
Q
N
Q
L
G
V
L
Site 16
Y209
G
Q
W
K
I
R
A
Y
Y
E
N
S
P
Q
Q
Site 17
Y210
Q
W
K
I
R
A
Y
Y
E
N
S
P
Q
Q
V
Site 18
S213
I
R
A
Y
Y
E
N
S
P
Q
Q
V
F
S
T
Site 19
Y227
T
E
F
E
V
K
E
Y
V
L
P
S
F
E
V
Site 20
Y244
E
P
T
E
K
F
Y
Y
I
Y
N
E
K
G
L
Site 21
Y246
T
E
K
F
Y
Y
I
Y
N
E
K
G
L
E
V
Site 22
Y261
T
I
T
A
R
F
L
Y
G
K
K
V
E
G
T
Site 23
S283
Q
D
G
E
Q
R
I
S
L
P
E
S
L
K
R
Site 24
S287
Q
R
I
S
L
P
E
S
L
K
R
I
P
I
E
Site 25
S297
R
I
P
I
E
D
G
S
G
E
V
V
L
S
R
Site 26
S336
T
V
I
L
H
S
G
S
D
M
V
Q
A
E
R
Site 27
T358
S
P
Y
Q
I
H
F
T
K
T
P
K
Y
F
K
Site 28
T360
Y
Q
I
H
F
T
K
T
P
K
Y
F
K
P
G
Site 29
Y363
H
F
T
K
T
P
K
Y
F
K
P
G
M
P
F
Site 30
S382
F
V
T
N
P
D
G
S
P
A
Y
R
V
P
V
Site 31
Y385
N
P
D
G
S
P
A
Y
R
V
P
V
A
V
Q
Site 32
T396
V
A
V
Q
G
E
D
T
V
Q
S
L
T
Q
G
Site 33
S399
Q
G
E
D
T
V
Q
S
L
T
Q
G
D
G
V
Site 34
S410
G
D
G
V
A
K
L
S
I
N
T
H
P
S
Q
Site 35
S416
L
S
I
N
T
H
P
S
Q
K
P
L
S
I
T
Site 36
S421
H
P
S
Q
K
P
L
S
I
T
V
R
T
K
K
Site 37
T423
S
Q
K
P
L
S
I
T
V
R
T
K
K
Q
E
Site 38
S432
R
T
K
K
Q
E
L
S
E
A
E
Q
A
T
R
Site 39
Y446
R
T
M
Q
A
L
P
Y
S
T
V
G
N
S
N
Site 40
S447
T
M
Q
A
L
P
Y
S
T
V
G
N
S
N
N
Site 41
T448
M
Q
A
L
P
Y
S
T
V
G
N
S
N
N
Y
Site 42
Y455
T
V
G
N
S
N
N
Y
L
H
L
S
V
L
R
Site 43
S459
S
N
N
Y
L
H
L
S
V
L
R
T
E
L
R
Site 44
T463
L
H
L
S
V
L
R
T
E
L
R
P
G
E
T
Site 45
Y489
A
H
E
A
K
I
R
Y
Y
T
Y
L
I
M
N
Site 46
Y490
H
E
A
K
I
R
Y
Y
T
Y
L
I
M
N
K
Site 47
T491
E
A
K
I
R
Y
Y
T
Y
L
I
M
N
K
G
Site 48
Y492
A
K
I
R
Y
Y
T
Y
L
I
M
N
K
G
R
Site 49
S550
Q
R
E
V
V
A
D
S
V
W
V
D
V
K
D
Site 50
S567
V
G
S
L
V
V
K
S
G
Q
S
E
D
R
Q
Site 51
T582
P
V
P
G
Q
Q
M
T
L
K
I
E
G
D
H
Site 52
T612
L
N
K
K
N
K
L
T
Q
S
K
I
W
D
V
Site 53
T628
E
K
A
D
I
G
C
T
P
G
S
G
K
D
Y
Site 54
S631
D
I
G
C
T
P
G
S
G
K
D
Y
A
G
V
Site 55
Y635
T
P
G
S
G
K
D
Y
A
G
V
F
S
D
A
Site 56
T645
V
F
S
D
A
G
L
T
F
T
S
S
S
G
Q
Site 57
S649
A
G
L
T
F
T
S
S
S
G
Q
Q
T
A
Q
Site 58
T654
T
S
S
S
G
Q
Q
T
A
Q
R
A
E
L
Q
Site 59
S672
P
A
A
R
R
R
R
S
V
Q
L
T
E
K
R
Site 60
T676
R
R
R
S
V
Q
L
T
E
K
R
M
D
K
V
Site 61
Y686
R
M
D
K
V
G
K
Y
P
K
E
L
R
K
C
Site 62
S706
R
E
N
P
M
R
F
S
C
Q
R
R
T
R
F
Site 63
T711
R
F
S
C
Q
R
R
T
R
F
I
S
L
G
E
Site 64
S715
Q
R
R
T
R
F
I
S
L
G
E
A
C
K
K
Site 65
Y730
V
F
L
D
C
C
N
Y
I
T
E
L
R
R
Q
Site 66
S742
R
R
Q
H
A
R
A
S
H
L
G
L
A
R
S
Site 67
S749
S
H
L
G
L
A
R
S
N
L
D
E
D
I
I
Site 68
S763
I
A
E
E
N
I
V
S
R
S
E
F
P
E
S
Site 69
S765
E
E
N
I
V
S
R
S
E
F
P
E
S
W
L
Site 70
S770
S
R
S
E
F
P
E
S
W
L
W
N
V
E
D
Site 71
Y837
F
I
D
L
R
L
P
Y
S
V
V
R
N
E
Q
Site 72
S838
I
D
L
R
L
P
Y
S
V
V
R
N
E
Q
V
Site 73
Y852
V
E
I
R
A
V
L
Y
N
Y
R
Q
N
Q
E
Site 74
S874
L
H
N
P
A
F
C
S
L
A
T
T
K
R
R
Site 75
T878
A
F
C
S
L
A
T
T
K
R
R
H
Q
Q
T
Site 76
T885
T
K
R
R
H
Q
Q
T
V
T
I
P
P
K
S
Site 77
T887
R
R
H
Q
Q
T
V
T
I
P
P
K
S
S
L
Site 78
S922
A
V
Y
H
H
F
I
S
D
G
V
R
K
S
L
Site 79
S928
I
S
D
G
V
R
K
S
L
K
V
V
P
E
G
Site 80
T941
E
G
I
R
M
N
K
T
V
A
V
R
T
L
D
Site 81
S968
D
I
P
P
A
D
L
S
D
Q
V
P
D
T
E
Site 82
T974
L
S
D
Q
V
P
D
T
E
S
E
T
R
I
L
Site 83
S976
D
Q
V
P
D
T
E
S
E
T
R
I
L
L
Q
Site 84
T1006
R
L
K
H
L
I
V
T
P
S
G
C
G
E
Q
Site 85
S1008
K
H
L
I
V
T
P
S
G
C
G
E
Q
N
M
Site 86
Y1027
P
T
V
I
A
V
H
Y
L
D
E
T
E
Q
W
Site 87
T1031
A
V
H
Y
L
D
E
T
E
Q
W
E
K
F
G
Site 88
S1164
I
C
E
E
Q
V
N
S
L
P
G
S
I
T
K
Site 89
S1168
Q
V
N
S
L
P
G
S
I
T
K
A
G
D
F
Site 90
Y1180
G
D
F
L
E
A
N
Y
M
N
L
Q
R
S
Y
Site 91
Y1187
Y
M
N
L
Q
R
S
Y
T
V
A
I
A
G
Y
Site 92
Y1194
Y
T
V
A
I
A
G
Y
A
L
A
Q
M
G
R
Site 93
T1212
P
L
L
N
K
F
L
T
T
A
K
D
K
N
R
Site 94
Y1228
E
D
P
G
K
Q
L
Y
N
V
E
A
T
S
Y
Site 95
Y1261
R
W
L
N
E
Q
R
Y
Y
G
G
G
Y
G
S
Site 96
Y1262
W
L
N
E
Q
R
Y
Y
G
G
G
Y
G
S
T
Site 97
S1297
Q
E
L
N
L
D
V
S
L
Q
L
P
S
R
S
Site 98
S1302
D
V
S
L
Q
L
P
S
R
S
S
K
I
T
H
Site 99
S1304
S
L
Q
L
P
S
R
S
S
K
I
T
H
R
I
Site 100
S1305
L
Q
L
P
S
R
S
S
K
I
T
H
R
I
H
Site 101
T1308
P
S
R
S
S
K
I
T
H
R
I
H
W
E
S
Site 102
S1315
T
H
R
I
H
W
E
S
A
S
L
L
R
S
E
Site 103
S1317
R
I
H
W
E
S
A
S
L
L
R
S
E
E
T
Site 104
S1321
E
S
A
S
L
L
R
S
E
E
T
K
E
N
E
Site 105
T1331
T
K
E
N
E
G
F
T
V
T
A
E
G
K
G
Site 106
T1341
A
E
G
K
G
Q
G
T
L
S
V
V
T
M
Y
Site 107
S1343
G
K
G
Q
G
T
L
S
V
V
T
M
Y
H
A
Site 108
T1357
A
K
A
K
D
Q
L
T
C
N
K
F
D
L
K
Site 109
T1366
N
K
F
D
L
K
V
T
I
K
P
A
P
E
T
Site 110
T1399
Y
R
G
D
Q
D
A
T
M
S
I
L
D
I
S
Site 111
T1415
M
T
G
F
A
P
D
T
D
D
L
K
Q
L
A
Site 112
Y1428
L
A
N
G
V
D
R
Y
I
S
K
Y
E
L
D
Site 113
S1430
N
G
V
D
R
Y
I
S
K
Y
E
L
D
K
A
Site 114
Y1432
V
D
R
Y
I
S
K
Y
E
L
D
K
A
F
S
Site 115
S1439
Y
E
L
D
K
A
F
S
D
R
N
T
L
I
I
Site 116
T1443
K
A
F
S
D
R
N
T
L
I
I
Y
L
D
K
Site 117
Y1447
D
R
N
T
L
I
I
Y
L
D
K
V
S
H
S
Site 118
S1454
Y
L
D
K
V
S
H
S
E
D
D
C
L
A
F
Site 119
Y1482
G
A
V
K
V
Y
A
Y
Y
N
L
E
E
S
C
Site 120
Y1493
E
E
S
C
T
R
F
Y
H
P
E
K
E
D
G
Site 121
S1523
E
N
C
F
I
Q
K
S
D
D
K
V
T
L
E
Site 122
T1528
Q
K
S
D
D
K
V
T
L
E
E
R
L
D
K
Site 123
Y1543
A
C
E
P
G
V
D
Y
V
Y
K
T
R
L
V
Site 124
Y1545
E
P
G
V
D
Y
V
Y
K
T
R
L
V
K
V
Site 125
S1555
R
L
V
K
V
Q
L
S
N
D
F
D
E
Y
I
Site 126
Y1561
L
S
N
D
F
D
E
Y
I
M
A
I
E
Q
T
Site 127
S1571
A
I
E
Q
T
I
K
S
G
S
D
E
V
Q
V
Site 128
S1573
E
Q
T
I
K
S
G
S
D
E
V
Q
V
G
Q
Site 129
T1583
V
Q
V
G
Q
Q
R
T
F
I
S
P
I
K
C
Site 130
S1586
G
Q
Q
R
T
F
I
S
P
I
K
C
R
E
A
Site 131
Y1602
K
L
E
E
K
K
H
Y
L
M
W
G
L
S
S
Site 132
S1619
W
G
E
K
P
N
L
S
Y
I
I
G
K
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation