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Updated November 2019
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Protein Info
Short Name:
C5
Full Name:
Complement C5
Alias:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Type:
Mass (Da):
188305
Number AA:
1676
UniProt ID:
P01031
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
T
W
G
Q
E
Q
T
Y
V
I
S
A
P
K
I
Site 2
T53
Y
T
E
A
F
D
A
T
I
S
I
K
S
Y
P
Site 3
S58
D
A
T
I
S
I
K
S
Y
P
D
K
K
F
S
Site 4
Y59
A
T
I
S
I
K
S
Y
P
D
K
K
F
S
Y
Site 5
S65
S
Y
P
D
K
K
F
S
Y
S
S
G
H
V
H
Site 6
Y66
Y
P
D
K
K
F
S
Y
S
S
G
H
V
H
L
Site 7
S67
P
D
K
K
F
S
Y
S
S
G
H
V
H
L
S
Site 8
S68
D
K
K
F
S
Y
S
S
G
H
V
H
L
S
S
Site 9
S74
S
S
G
H
V
H
L
S
S
E
N
K
F
Q
N
Site 10
S75
S
G
H
V
H
L
S
S
E
N
K
F
Q
N
S
Site 11
T86
F
Q
N
S
A
I
L
T
I
Q
P
K
Q
L
P
Site 12
Y103
Q
N
P
V
S
Y
V
Y
L
E
V
V
S
K
H
Site 13
S108
Y
V
Y
L
E
V
V
S
K
H
F
S
K
S
K
Site 14
S112
E
V
V
S
K
H
F
S
K
S
K
R
M
P
I
Site 15
S114
V
S
K
H
F
S
K
S
K
R
M
P
I
T
Y
Site 16
T120
K
S
K
R
M
P
I
T
Y
D
N
G
F
L
F
Site 17
Y121
S
K
R
M
P
I
T
Y
D
N
G
F
L
F
I
Site 18
T130
N
G
F
L
F
I
H
T
D
K
P
V
Y
T
P
Site 19
Y135
I
H
T
D
K
P
V
Y
T
P
D
Q
S
V
K
Site 20
T136
H
T
D
K
P
V
Y
T
P
D
Q
S
V
K
V
Site 21
S140
P
V
Y
T
P
D
Q
S
V
K
V
R
V
Y
S
Site 22
Y146
Q
S
V
K
V
R
V
Y
S
L
N
D
D
L
K
Site 23
S147
S
V
K
V
R
V
Y
S
L
N
D
D
L
K
P
Site 24
T159
L
K
P
A
K
R
E
T
V
L
T
F
I
D
P
Site 25
T162
A
K
R
E
T
V
L
T
F
I
D
P
E
G
S
Site 26
Y196
K
I
P
S
N
P
R
Y
G
M
W
T
I
K
A
Site 27
T200
N
P
R
Y
G
M
W
T
I
K
A
K
Y
K
E
Site 28
Y205
M
W
T
I
K
A
K
Y
K
E
D
F
S
T
T
Site 29
S210
A
K
Y
K
E
D
F
S
T
T
G
T
A
Y
F
Site 30
T211
K
Y
K
E
D
F
S
T
T
G
T
A
Y
F
E
Site 31
T214
E
D
F
S
T
T
G
T
A
Y
F
E
V
K
E
Site 32
Y216
F
S
T
T
G
T
A
Y
F
E
V
K
E
Y
V
Site 33
S228
E
Y
V
L
P
H
F
S
V
S
I
E
P
E
Y
Site 34
Y235
S
V
S
I
E
P
E
Y
N
F
I
G
Y
K
N
Site 35
Y254
E
I
T
I
K
A
R
Y
F
Y
N
K
V
V
T
Site 36
Y256
T
I
K
A
R
Y
F
Y
N
K
V
V
T
E
A
Site 37
T305
Q
V
T
F
D
S
E
T
A
V
K
E
L
S
Y
Site 38
S311
E
T
A
V
K
E
L
S
Y
Y
S
L
E
D
L
Site 39
Y313
A
V
K
E
L
S
Y
Y
S
L
E
D
L
N
N
Site 40
S314
V
K
E
L
S
Y
Y
S
L
E
D
L
N
N
K
Site 41
S378
I
K
V
Q
V
K
D
S
L
D
Q
L
V
G
G
Site 42
S407
E
T
S
D
L
D
P
S
K
S
V
T
R
V
D
Site 43
S409
S
D
L
D
P
S
K
S
V
T
R
V
D
D
G
Site 44
T411
L
D
P
S
K
S
V
T
R
V
D
D
G
V
A
Site 45
T437
V
L
E
F
N
V
K
T
D
A
P
D
L
P
E
Site 46
Y452
E
N
Q
A
R
E
G
Y
R
A
I
A
Y
S
S
Site 47
Y457
E
G
Y
R
A
I
A
Y
S
S
L
S
Q
S
Y
Site 48
S458
G
Y
R
A
I
A
Y
S
S
L
S
Q
S
Y
L
Site 49
S459
Y
R
A
I
A
Y
S
S
L
S
Q
S
Y
L
Y
Site 50
S463
A
Y
S
S
L
S
Q
S
Y
L
Y
I
D
W
T
Site 51
Y466
S
L
S
Q
S
Y
L
Y
I
D
W
T
D
N
H
Site 52
T487
E
H
L
N
I
I
V
T
P
K
S
P
Y
I
D
Site 53
S490
N
I
I
V
T
P
K
S
P
Y
I
D
K
I
T
Site 54
Y499
Y
I
D
K
I
T
H
Y
N
Y
L
I
L
S
K
Site 55
Y501
D
K
I
T
H
Y
N
Y
L
I
L
S
K
G
K
Site 56
T514
G
K
I
I
H
F
G
T
R
E
K
F
S
D
A
Site 57
S519
F
G
T
R
E
K
F
S
D
A
S
Y
Q
S
I
Site 58
S522
R
E
K
F
S
D
A
S
Y
Q
S
I
N
I
P
Site 59
Y523
E
K
F
S
D
A
S
Y
Q
S
I
N
I
P
V
Site 60
T531
Q
S
I
N
I
P
V
T
Q
N
M
V
P
S
S
Site 61
Y543
P
S
S
R
L
L
V
Y
Y
I
V
T
G
E
Q
Site 62
S556
E
Q
T
A
E
L
V
S
D
S
V
W
L
N
I
Site 63
S558
T
A
E
L
V
S
D
S
V
W
L
N
I
E
E
Site 64
S576
N
Q
L
Q
V
H
L
S
P
D
A
D
A
Y
S
Site 65
Y582
L
S
P
D
A
D
A
Y
S
P
G
Q
T
V
S
Site 66
S583
S
P
D
A
D
A
Y
S
P
G
Q
T
V
S
L
Site 67
T587
D
A
Y
S
P
G
Q
T
V
S
L
N
M
A
T
Site 68
S589
Y
S
P
G
Q
T
V
S
L
N
M
A
T
G
M
Site 69
S662
T
N
A
N
A
D
D
S
Q
E
N
D
E
P
C
Site 70
T678
E
I
L
R
P
R
R
T
L
Q
K
K
I
E
E
Site 71
Y690
I
E
E
I
A
A
K
Y
K
H
S
V
V
K
K
Site 72
S693
I
A
A
K
Y
K
H
S
V
V
K
K
C
C
Y
Site 73
Y700
S
V
V
K
K
C
C
Y
D
G
A
C
V
N
N
Site 74
T710
A
C
V
N
N
D
E
T
C
E
Q
R
A
A
R
Site 75
S719
E
Q
R
A
A
R
I
S
L
G
P
R
C
I
K
Site 76
T729
P
R
C
I
K
A
F
T
E
C
C
V
V
A
S
Site 77
S736
T
E
C
C
V
V
A
S
Q
L
R
A
N
I
S
Site 78
S743
S
Q
L
R
A
N
I
S
H
K
D
M
Q
L
G
Site 79
T756
L
G
R
L
H
M
K
T
L
L
P
V
S
K
P
Site 80
S761
M
K
T
L
L
P
V
S
K
P
E
I
R
S
Y
Site 81
S767
V
S
K
P
E
I
R
S
Y
F
P
E
S
W
L
Site 82
Y768
S
K
P
E
I
R
S
Y
F
P
E
S
W
L
W
Site 83
Y831
F
L
E
M
N
I
P
Y
S
V
V
R
G
E
Q
Site 84
S832
L
E
M
N
I
P
Y
S
V
V
R
G
E
Q
I
Site 85
T844
E
Q
I
Q
L
K
G
T
V
Y
N
Y
R
T
S
Site 86
Y846
I
Q
L
K
G
T
V
Y
N
Y
R
T
S
G
M
Site 87
Y848
L
K
G
T
V
Y
N
Y
R
T
S
G
M
Q
F
Site 88
S870
E
G
I
C
T
S
E
S
P
V
I
D
H
Q
G
Site 89
S880
I
D
H
Q
G
T
K
S
S
K
C
V
R
Q
K
Site 90
S881
D
H
Q
G
T
K
S
S
K
C
V
R
Q
K
V
Site 91
S893
Q
K
V
E
G
S
S
S
H
L
V
T
F
T
V
Site 92
S938
P
E
G
V
K
R
E
S
Y
S
G
V
T
L
D
Site 93
Y939
E
G
V
K
R
E
S
Y
S
G
V
T
L
D
P
Site 94
S940
G
V
K
R
E
S
Y
S
G
V
T
L
D
P
R
Site 95
T943
R
E
S
Y
S
G
V
T
L
D
P
R
G
I
Y
Site 96
Y950
T
L
D
P
R
G
I
Y
G
T
I
S
R
R
K
Site 97
T952
D
P
R
G
I
Y
G
T
I
S
R
R
K
E
F
Site 98
S954
R
G
I
Y
G
T
I
S
R
R
K
E
F
P
Y
Site 99
Y961
S
R
R
K
E
F
P
Y
R
I
P
L
D
L
V
Site 100
T971
P
L
D
L
V
P
K
T
E
I
K
R
I
L
S
Site 101
T1001
Q
E
G
I
N
I
L
T
H
L
P
K
G
S
A
Site 102
S1055
K
L
K
E
G
M
L
S
I
M
S
Y
R
N
A
Site 103
S1058
E
G
M
L
S
I
M
S
Y
R
N
A
D
Y
S
Site 104
Y1059
G
M
L
S
I
M
S
Y
R
N
A
D
Y
S
Y
Site 105
Y1064
M
S
Y
R
N
A
D
Y
S
Y
S
V
W
K
G
Site 106
S1065
S
Y
R
N
A
D
Y
S
Y
S
V
W
K
G
G
Site 107
Y1066
Y
R
N
A
D
Y
S
Y
S
V
W
K
G
G
S
Site 108
S1067
R
N
A
D
Y
S
Y
S
V
W
K
G
G
S
A
Site 109
S1073
Y
S
V
W
K
G
G
S
A
S
T
W
L
T
A
Site 110
Y1092
V
L
G
Q
V
N
K
Y
V
E
Q
N
Q
N
S
Site 111
Y1111
L
L
W
L
V
E
N
Y
Q
L
D
N
G
S
F
Site 112
S1117
N
Y
Q
L
D
N
G
S
F
K
E
N
S
Q
Y
Site 113
S1122
N
G
S
F
K
E
N
S
Q
Y
Q
P
I
K
L
Site 114
Y1124
S
F
K
E
N
S
Q
Y
Q
P
I
K
L
Q
G
Site 115
S1141
P
V
E
A
R
E
N
S
L
Y
L
T
A
F
T
Site 116
S1196
A
I
S
A
Y
A
L
S
L
G
D
K
T
H
P
Site 117
T1201
A
L
S
L
G
D
K
T
H
P
Q
F
R
S
I
Site 118
S1207
K
T
H
P
Q
F
R
S
I
V
S
A
L
K
R
Site 119
Y1225
V
K
G
N
P
P
I
Y
R
F
W
K
D
N
L
Site 120
S1237
D
N
L
Q
H
K
D
S
S
V
P
N
T
G
T
Site 121
S1238
N
L
Q
H
K
D
S
S
V
P
N
T
G
T
A
Site 122
T1242
K
D
S
S
V
P
N
T
G
T
A
R
M
V
E
Site 123
Y1266
L
N
L
K
D
I
N
Y
V
N
P
V
I
K
W
Site 124
S1275
N
P
V
I
K
W
L
S
E
E
Q
R
Y
G
G
Site 125
Y1280
W
L
S
E
E
Q
R
Y
G
G
G
F
Y
S
T
Site 126
S1286
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
Site 127
T1290
G
F
Y
S
T
Q
D
T
I
N
A
I
E
G
L
Site 128
S1316
L
S
M
D
I
D
V
S
Y
K
H
K
G
A
L
Site 129
Y1317
S
M
D
I
D
V
S
Y
K
H
K
G
A
L
H
Site 130
S1371
V
V
H
K
T
S
T
S
E
E
V
C
S
F
Y
Site 131
S1376
S
T
S
E
E
V
C
S
F
Y
L
K
I
D
T
Site 132
Y1378
S
E
E
V
C
S
F
Y
L
K
I
D
T
Q
D
Site 133
T1383
S
F
Y
L
K
I
D
T
Q
D
I
E
A
S
H
Site 134
Y1391
Q
D
I
E
A
S
H
Y
R
G
Y
G
N
S
D
Site 135
Y1394
E
A
S
H
Y
R
G
Y
G
N
S
D
Y
K
R
Site 136
Y1399
R
G
Y
G
N
S
D
Y
K
R
I
V
A
C
A
Site 137
S1407
K
R
I
V
A
C
A
S
Y
K
P
S
R
E
E
Site 138
S1411
A
C
A
S
Y
K
P
S
R
E
E
S
S
S
G
Site 139
S1415
Y
K
P
S
R
E
E
S
S
S
G
S
S
H
A
Site 140
S1416
K
P
S
R
E
E
S
S
S
G
S
S
H
A
V
Site 141
S1417
P
S
R
E
E
S
S
S
G
S
S
H
A
V
M
Site 142
S1419
R
E
E
S
S
S
G
S
S
H
A
V
M
D
I
Site 143
S1420
E
E
S
S
S
G
S
S
H
A
V
M
D
I
S
Site 144
Y1453
V
D
Q
L
F
T
D
Y
Q
I
K
D
G
H
V
Site 145
Y1496
S
P
A
T
F
T
V
Y
E
Y
H
R
P
D
K
Site 146
Y1498
A
T
F
T
V
Y
E
Y
H
R
P
D
K
Q
C
Site 147
T1542
M
Q
E
E
L
D
L
T
I
S
A
E
T
R
K
Site 148
T1551
S
A
E
T
R
K
Q
T
A
C
K
P
E
I
A
Site 149
T1599
A
E
K
D
S
E
I
T
F
I
K
K
V
T
C
Site 150
Y1617
E
L
V
K
G
R
Q
Y
L
I
M
G
K
E
A
Site 151
Y1629
K
E
A
L
Q
I
K
Y
N
F
S
F
R
Y
I
Site 152
Y1635
K
Y
N
F
S
F
R
Y
I
Y
P
L
D
S
L
Site 153
Y1637
N
F
S
F
R
Y
I
Y
P
L
D
S
L
T
W
Site 154
S1656
P
R
D
T
T
C
S
S
C
Q
A
F
L
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation