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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KNG1
Full Name:
Kininogen-1
Alias:
alpha-2-thiol proteinase inhibitor; BDK; bradykinin; kininogen; kininogen 1; KNG
Type:
Inhibitor protein; Adhesion; Contractile protein
Mass (Da):
71960
Number AA:
UniProt ID:
P01042
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0004869
GO:0008201
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007596
GO:0030146
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
C
S
R
L
L
L
S
L
T
Q
E
S
Q
S
Site 2
T18
S
R
L
L
L
S
L
T
Q
E
S
Q
S
E
E
Site 3
S21
L
L
S
L
T
Q
E
S
Q
S
E
E
I
D
C
Site 4
S23
S
L
T
Q
E
S
Q
S
E
E
I
D
C
N
D
Site 5
Y44
V
D
A
A
L
K
K
Y
N
S
Q
N
Q
S
N
Site 6
S46
A
A
L
K
K
Y
N
S
Q
N
Q
S
N
N
Q
Site 7
Y57
S
N
N
Q
F
V
L
Y
R
I
T
E
A
T
K
Site 8
T63
L
Y
R
I
T
E
A
T
K
T
V
G
S
D
T
Site 9
T65
R
I
T
E
A
T
K
T
V
G
S
D
T
F
Y
Site 10
S68
E
A
T
K
T
V
G
S
D
T
F
Y
S
F
K
Site 11
T70
T
K
T
V
G
S
D
T
F
Y
S
F
K
Y
E
Site 12
Y72
T
V
G
S
D
T
F
Y
S
F
K
Y
E
I
K
Site 13
S73
V
G
S
D
T
F
Y
S
F
K
Y
E
I
K
E
Site 14
Y76
D
T
F
Y
S
F
K
Y
E
I
K
E
G
D
C
Site 15
Y96
K
T
W
Q
D
C
E
Y
K
D
A
A
K
A
A
Site 16
T110
A
T
G
E
C
T
A
T
V
G
K
R
S
S
T
Site 17
S116
A
T
V
G
K
R
S
S
T
K
F
S
V
A
T
Site 18
T117
T
V
G
K
R
S
S
T
K
F
S
V
A
T
Q
Site 19
S120
K
R
S
S
T
K
F
S
V
A
T
Q
T
C
Q
Site 20
S150
L
G
C
V
H
P
I
S
T
Q
S
P
D
L
E
Site 21
T151
G
C
V
H
P
I
S
T
Q
S
P
D
L
E
P
Site 22
S153
V
H
P
I
S
T
Q
S
P
D
L
E
P
I
L
Site 23
Y166
I
L
R
H
G
I
Q
Y
F
N
N
N
T
Q
H
Site 24
T204
I
T
Y
S
I
V
Q
T
N
C
S
K
E
N
F
Site 25
T215
K
E
N
F
L
F
L
T
P
D
C
K
S
L
W
Site 26
T226
K
S
L
W
N
G
D
T
G
E
C
T
D
N
A
Site 27
Y234
G
E
C
T
D
N
A
Y
I
D
I
Q
L
R
I
Site 28
S243
D
I
Q
L
R
I
A
S
F
S
Q
N
C
D
I
Site 29
S245
Q
L
R
I
A
S
F
S
Q
N
C
D
I
Y
P
Site 30
Y251
F
S
Q
N
C
D
I
Y
P
G
K
D
F
V
Q
Site 31
T273
G
C
P
R
D
I
P
T
N
S
P
E
L
E
E
Site 32
S275
P
R
D
I
P
T
N
S
P
E
L
E
E
T
L
Site 33
T281
N
S
P
E
L
E
E
T
L
T
H
T
I
T
K
Site 34
T283
P
E
L
E
E
T
L
T
H
T
I
T
K
L
N
Site 35
Y298
A
E
N
N
A
T
F
Y
F
K
I
D
N
V
K
Site 36
T326
I
D
F
V
A
R
E
T
T
C
S
K
E
S
N
Site 37
T327
D
F
V
A
R
E
T
T
C
S
K
E
S
N
E
Site 38
S329
V
A
R
E
T
T
C
S
K
E
S
N
E
E
L
Site 39
S332
E
T
T
C
S
K
E
S
N
E
E
L
T
E
S
Site 40
S339
S
N
E
E
L
T
E
S
C
E
T
K
K
L
G
Site 41
T342
E
L
T
E
S
C
E
T
K
K
L
G
Q
S
L
Site 42
Y356
L
D
C
N
A
E
V
Y
V
V
P
W
E
K
K
Site 43
Y365
V
P
W
E
K
K
I
Y
P
T
V
N
C
Q
P
Site 44
S377
C
Q
P
L
G
M
I
S
L
M
K
R
P
P
G
Site 45
S386
M
K
R
P
P
G
F
S
P
F
R
S
S
R
I
Site 46
S390
P
G
F
S
P
F
R
S
S
R
I
G
E
I
K
Site 47
S391
G
F
S
P
F
R
S
S
R
I
G
E
I
K
E
Site 48
T400
I
G
E
I
K
E
E
T
T
V
S
P
P
H
T
Site 49
T401
G
E
I
K
E
E
T
T
V
S
P
P
H
T
S
Site 50
S403
I
K
E
E
T
T
V
S
P
P
H
T
S
M
A
Site 51
T407
T
T
V
S
P
P
H
T
S
M
A
P
A
Q
D
Site 52
S408
T
V
S
P
P
H
T
S
M
A
P
A
Q
D
E
Site 53
S419
A
Q
D
E
E
R
D
S
G
K
E
Q
G
H
T
Site 54
T426
S
G
K
E
Q
G
H
T
R
R
H
D
W
G
H
Site 55
T521
G
K
H
N
G
W
K
T
E
H
L
A
S
S
S
Site 56
S526
W
K
T
E
H
L
A
S
S
S
E
D
S
T
T
Site 57
S527
K
T
E
H
L
A
S
S
S
E
D
S
T
T
P
Site 58
S528
T
E
H
L
A
S
S
S
E
D
S
T
T
P
S
Site 59
S531
L
A
S
S
S
E
D
S
T
T
P
S
A
Q
T
Site 60
T532
A
S
S
S
E
D
S
T
T
P
S
A
Q
T
Q
Site 61
T533
S
S
S
E
D
S
T
T
P
S
A
Q
T
Q
E
Site 62
S535
S
E
D
S
T
T
P
S
A
Q
T
Q
E
K
T
Site 63
T542
S
A
Q
T
Q
E
K
T
E
G
P
T
P
I
P
Site 64
T546
Q
E
K
T
E
G
P
T
P
I
P
S
L
A
K
Site 65
S550
E
G
P
T
P
I
P
S
L
A
K
P
G
V
T
Site 66
T559
A
K
P
G
V
T
V
T
F
S
D
F
Q
D
S
Site 67
S561
P
G
V
T
V
T
F
S
D
F
Q
D
S
D
L
Site 68
T571
Q
D
S
D
L
I
A
T
M
M
P
P
I
S
P
Site 69
S577
A
T
M
M
P
P
I
S
P
A
P
I
Q
S
D
Site 70
S583
I
S
P
A
P
I
Q
S
D
D
D
W
I
P
D
Site 71
S599
Q
I
D
P
N
G
L
S
F
N
P
I
S
D
F
Site 72
S604
G
L
S
F
N
P
I
S
D
F
P
D
T
T
S
Site 73
T609
P
I
S
D
F
P
D
T
T
S
P
K
C
P
G
Site 74
T610
I
S
D
F
P
D
T
T
S
P
K
C
P
G
R
Site 75
S611
S
D
F
P
D
T
T
S
P
K
C
P
G
R
P
Site 76
S621
C
P
G
R
P
W
K
S
V
S
E
I
N
P
T
Site 77
S623
G
R
P
W
K
S
V
S
E
I
N
P
T
T
Q
Site 78
T628
S
V
S
E
I
N
P
T
T
Q
M
K
E
S
Y
Site 79
T629
V
S
E
I
N
P
T
T
Q
M
K
E
S
Y
Y
Site 80
Y636
T
Q
M
K
E
S
Y
Y
F
D
L
T
D
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation