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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PENK
Full Name:
Proenkephalin-A
Alias:
Opioid growth factor; Opioid growth factorPenk; Penk; Preproenkephalin; Proenkephalin; Proenkephalin A
Type:
Mass (Da):
30787
Number AA:
267
UniProt ID:
P01210
International Prot ID:
IPI00000828
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005184
GO:0001515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
A
T
V
R
A
E
C
S
Q
D
C
A
T
C
S
Site 2
T32
E
C
S
Q
D
C
A
T
C
S
Y
R
L
V
R
Site 3
S34
S
Q
D
C
A
T
C
S
Y
R
L
V
R
P
A
Site 4
S58
E
C
E
G
K
L
P
S
L
K
I
W
E
T
C
Site 5
T64
P
S
L
K
I
W
E
T
C
K
E
L
L
Q
L
Site 6
S72
C
K
E
L
L
Q
L
S
K
P
E
L
P
Q
D
Site 7
T81
P
E
L
P
Q
D
G
T
S
T
L
R
E
N
S
Site 8
S82
E
L
P
Q
D
G
T
S
T
L
R
E
N
S
K
Site 9
T83
L
P
Q
D
G
T
S
T
L
R
E
N
S
K
P
Site 10
S88
T
S
T
L
R
E
N
S
K
P
E
E
S
H
L
Site 11
Y100
S
H
L
L
A
K
R
Y
G
G
F
M
K
R
Y
Site 12
Y107
Y
G
G
F
M
K
R
Y
G
G
F
M
K
K
M
Site 13
Y118
M
K
K
M
D
E
L
Y
P
M
E
P
E
E
E
Site 14
S129
P
E
E
E
A
N
G
S
E
I
L
A
K
R
Y
Site 15
S149
K
D
A
E
E
D
D
S
L
A
N
S
S
D
L
Site 16
S153
E
D
D
S
L
A
N
S
S
D
L
L
K
E
L
Site 17
T163
L
L
K
E
L
L
E
T
G
D
N
R
E
R
S
Site 18
S170
T
G
D
N
R
E
R
S
H
H
Q
D
G
S
D
Site 19
S176
R
S
H
H
Q
D
G
S
D
N
E
E
E
V
S
Site 20
S183
S
D
N
E
E
E
V
S
K
R
Y
G
G
F
M
Site 21
S196
F
M
R
G
L
K
R
S
P
Q
L
E
D
E
A
Site 22
S243
R
F
A
E
A
L
P
S
D
E
E
G
E
S
Y
Site 23
S249
P
S
D
E
E
G
E
S
Y
S
K
E
V
P
E
Site 24
Y250
S
D
E
E
G
E
S
Y
S
K
E
V
P
E
M
Site 25
S251
D
E
E
G
E
S
Y
S
K
E
V
P
E
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation