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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IL1A
Full Name:
Interleukin-1 alpha
Alias:
Hematopoietin-1; IL1; IL-1A; IL1F1; Interleukin 1, alpha; Interleukin-1 alpha; Preinterleukin 1 alpha; Pro-interleukin-1-alpha
Type:
Cytokine
Mass (Da):
30588
Number AA:
271
UniProt ID:
P01583
International Prot ID:
IPI00003096
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0005149
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
E
D
L
K
N
C
Y
S
E
N
E
E
D
S
S
Site 2
S22
Y
S
E
N
E
E
D
S
S
S
I
D
H
L
S
Site 3
S23
S
E
N
E
E
D
S
S
S
I
D
H
L
S
L
Site 4
S24
E
N
E
E
D
S
S
S
I
D
H
L
S
L
N
Site 5
S29
S
S
S
I
D
H
L
S
L
N
Q
K
S
F
Y
Site 6
S34
H
L
S
L
N
Q
K
S
F
Y
H
V
S
Y
G
Site 7
Y36
S
L
N
Q
K
S
F
Y
H
V
S
Y
G
P
L
Site 8
S39
Q
K
S
F
Y
H
V
S
Y
G
P
L
H
E
G
Site 9
S51
H
E
G
C
M
D
Q
S
V
S
L
S
I
S
E
Site 10
S53
G
C
M
D
Q
S
V
S
L
S
I
S
E
T
S
Site 11
S55
M
D
Q
S
V
S
L
S
I
S
E
T
S
K
T
Site 12
S57
Q
S
V
S
L
S
I
S
E
T
S
K
T
S
K
Site 13
T59
V
S
L
S
I
S
E
T
S
K
T
S
K
L
T
Site 14
S60
S
L
S
I
S
E
T
S
K
T
S
K
L
T
F
Site 15
T62
S
I
S
E
T
S
K
T
S
K
L
T
F
K
E
Site 16
T66
T
S
K
T
S
K
L
T
F
K
E
S
M
V
V
Site 17
S87
V
L
K
K
R
R
L
S
L
S
Q
S
I
T
D
Site 18
S89
K
K
R
R
L
S
L
S
Q
S
I
T
D
D
D
Site 19
S91
R
R
L
S
L
S
Q
S
I
T
D
D
D
L
E
Site 20
T93
L
S
L
S
Q
S
I
T
D
D
D
L
E
A
I
Site 21
S104
L
E
A
I
A
N
D
S
E
E
E
I
I
K
P
Site 22
S113
E
E
I
I
K
P
R
S
A
P
F
S
F
L
S
Site 23
S117
K
P
R
S
A
P
F
S
F
L
S
N
V
K
Y
Site 24
S173
F
D
M
G
A
Y
K
S
S
K
D
D
A
K
I
Site 25
T181
S
K
D
D
A
K
I
T
V
I
L
R
I
S
K
Site 26
T189
V
I
L
R
I
S
K
T
Q
L
Y
V
T
A
Q
Site 27
Y192
R
I
S
K
T
Q
L
Y
V
T
A
Q
D
E
D
Site 28
T213
E
M
P
E
I
P
K
T
I
T
G
S
E
T
N
Site 29
Y233
E
T
H
G
T
K
N
Y
F
T
S
V
A
H
P
Site 30
T262
A
G
G
P
P
S
I
T
D
F
Q
I
L
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation