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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGHG3
Full Name:
Ig gamma-3 chain C region
Alias:
HDC;Heavy chain disease protein
Type:
Mass (Da):
41287
Number AA:
377
UniProt ID:
P01860
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
V
F
P
L
A
P
C
S
R
S
T
S
G
G
T
Site 2
S17
P
L
A
P
C
S
R
S
T
S
G
G
T
A
A
Site 3
S19
A
P
C
S
R
S
T
S
G
G
T
A
A
L
G
Site 4
T38
D
Y
F
P
E
P
V
T
V
S
W
N
S
G
A
Site 5
T47
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
Site 6
T78
V
P
S
S
S
L
G
T
Q
T
Y
T
C
N
V
Site 7
Y81
S
S
L
G
T
Q
T
Y
T
C
N
V
N
H
K
Site 8
T102
D
K
R
V
E
L
K
T
P
L
G
D
T
T
H
Site 9
T107
L
K
T
P
L
G
D
T
T
H
T
C
P
R
C
Site 10
T110
P
L
G
D
T
T
H
T
C
P
R
C
P
E
P
Site 11
T122
P
E
P
K
S
C
D
T
P
P
P
C
P
R
C
Site 12
T180
F
P
P
K
P
K
D
T
L
M
I
S
R
T
P
Site 13
S184
P
K
D
T
L
M
I
S
R
T
P
E
V
T
C
Site 14
S197
T
C
V
V
V
D
V
S
H
E
D
P
E
V
Q
Site 15
Y208
P
E
V
Q
F
K
W
Y
V
D
G
V
E
V
H
Site 16
T219
V
E
V
H
N
A
K
T
K
P
R
E
E
Q
Y
Site 17
S228
P
R
E
E
Q
Y
N
S
T
F
R
V
V
S
V
Site 18
T229
R
E
E
Q
Y
N
S
T
F
R
V
V
S
V
L
Site 19
Y249
D
W
L
N
G
K
E
Y
K
C
K
V
S
N
K
Site 20
T265
L
P
A
P
I
E
K
T
I
S
K
T
K
G
Q
Site 21
S267
A
P
I
E
K
T
I
S
K
T
K
G
Q
P
R
Site 22
Y279
Q
P
R
E
P
Q
V
Y
T
L
P
P
S
R
E
Site 23
T280
P
R
E
P
Q
V
Y
T
L
P
P
S
R
E
E
Site 24
S284
Q
V
Y
T
L
P
P
S
R
E
E
M
T
K
N
Site 25
S294
E
M
T
K
N
Q
V
S
L
T
C
L
V
K
G
Site 26
S314
I
A
V
E
W
E
S
S
G
Q
P
E
N
N
Y
Site 27
Y321
S
G
Q
P
E
N
N
Y
N
T
T
P
P
M
L
Site 28
T324
P
E
N
N
Y
N
T
T
P
P
M
L
D
S
D
Site 29
S330
T
T
P
P
M
L
D
S
D
G
S
F
F
L
Y
Site 30
S333
P
M
L
D
S
D
G
S
F
F
L
Y
S
K
L
Site 31
Y337
S
D
G
S
F
F
L
Y
S
K
L
T
V
D
K
Site 32
T341
F
F
L
Y
S
K
L
T
V
D
K
S
R
W
Q
Site 33
S345
S
K
L
T
V
D
K
S
R
W
Q
Q
G
N
I
Site 34
T367
E
A
L
H
N
R
F
T
Q
K
S
L
S
L
S
Site 35
S370
H
N
R
F
T
Q
K
S
L
S
L
S
P
G
K
Site 36
S372
R
F
T
Q
K
S
L
S
L
S
P
G
K
_
_
Site 37
S374
T
Q
K
S
L
S
L
S
P
G
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation