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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRYAA
Full Name:
Alpha-crystallin A chain
Alias:
Alpha crystallin A chain; Crystallin, alpha A; Crystallin, alphaA; Heat shock protein beta-4; Heat-shock protein beta-4; HspB4
Type:
Chaperone protein
Mass (Da):
19909
Number AA:
173
UniProt ID:
P02489
International Prot ID:
IPI00021062
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005212
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0032387
GO:0051260
Phosida
TranscriptoNet
STRING
Kinexus Products
Alpha A Crystallin pan-specific antibody AB-NN149-5#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN149-5
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
D
V
T
I
Q
H
P
W
F
K
Site 2
T13
Q
H
P
W
F
K
R
T
L
G
P
F
Y
P
S
Site 3
Y18
K
R
T
L
G
P
F
Y
P
S
R
L
F
D
Q
Site 4
S42
D
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Site 5
T43
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
Site 6
S45
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
Site 7
Y47
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
Site 8
Y48
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
T
Site 9
S51
I
S
P
Y
Y
R
Q
S
L
F
R
T
V
L
D
Site 10
T55
Y
R
Q
S
L
F
R
T
V
L
D
S
G
I
S
Site 11
S59
L
F
R
T
V
L
D
S
G
I
S
E
V
R
S
Site 12
S62
T
V
L
D
S
G
I
S
E
V
R
S
D
R
D
Site 13
S66
S
G
I
S
E
V
R
S
D
R
D
K
F
V
I
Site 14
S81
F
L
D
V
K
H
F
S
P
E
D
L
T
V
K
Site 15
T86
H
F
S
P
E
D
L
T
V
K
V
Q
D
D
F
Site 16
Y109
E
R
Q
D
D
H
G
Y
I
S
R
E
F
H
R
Site 17
Y118
S
R
E
F
H
R
R
Y
R
L
P
S
N
V
D
Site 18
S122
H
R
R
Y
R
L
P
S
N
V
D
Q
S
A
L
Site 19
S127
L
P
S
N
V
D
Q
S
A
L
S
C
S
L
S
Site 20
S130
N
V
D
Q
S
A
L
S
C
S
L
S
A
D
G
Site 21
T140
L
S
A
D
G
M
L
T
F
C
G
P
K
I
Q
Site 22
T148
F
C
G
P
K
I
Q
T
G
L
D
A
T
H
A
Site 23
S162
A
E
R
A
I
P
V
S
R
E
E
K
P
T
S
Site 24
T168
V
S
R
E
E
K
P
T
S
A
P
S
S
_
_
Site 25
S169
S
R
E
E
K
P
T
S
A
P
S
S
_
_
_
Site 26
S173
K
P
T
S
A
P
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation